Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects^[*]

Continuous monitoring of cardiac output and sequential studies of right ventricular ejection fraction and of fractional myocardial uptake of substances with high cell affinity can be realized using ¹³N (t_1/2 = 9.6 min) and ^81mKr (t_1/2 = 13 sec). Thus, it is possible to measure rapid changes of absolute myocardial blood flow and of the inotropic state of the right heart myocardium. This is shown in patients who underwent interventions with Dipyridamole and with Dobutamine which produce a marked increase in myocardial blood flow or cardiac dynamics, respectively.

Die Verwendung von ¹³N (t_1/2 = 9.6 Min.) und ^81mKr (t_1/2 = 13 Sek.) erlaubt, das Verhalten des Herzzeitvolumens kontinuierlich aufzuzeichnen und Untersuchungen der rechtsventrikulären Ejektionsfraktion sowie der prozentualen Aufnahme von zellaffinen Substanzen durch das Myokard kurzfristig zu wiederholen. Dadurch ist es möglich, schnelle Veränderungen der Myokarddurchblutung und der rechtsventrikulären Funktion nachzuweisen. Dies wird an Patienten bestätigt, bei denen die Myokarddurchblutung mit Hilfe von Dipyridamol und die Kontraktionskraft des Herzens durch Dobutamin gesteigert wird.

^* This paper is dedicated to Prof. Dr. K. E. Scheer on the occasion of his 60^th birthday.

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