Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects

W. H. Knapp; F. Helus; H. Tillmanns; R. Elfner; H. Ostertag; W. Kübler

doi:10.1055/s-0037-1620944

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1980; 19(04): 161-165
DOI: 10.1055/s-0037-1620944

Originalarbeiten — Original Articles

Schattauer GmbH

Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects^[*]

Kurzlebige Radionuklide zur Erfassung pharmakologischer Wirkungen auf das kardiovaskuläre System

Authors

W. H. Knapp

¹ From the Institute for Nuclear Medicine, German Cancer Research Center Heidelberg, Fed. Rep. Germany
F. Helus

¹ From the Institute for Nuclear Medicine, German Cancer Research Center Heidelberg, Fed. Rep. Germany
H. Tillmanns

¹ From the Institute for Nuclear Medicine, German Cancer Research Center Heidelberg, Fed. Rep. Germany
R. Elfner

¹ From the Institute for Nuclear Medicine, German Cancer Research Center Heidelberg, Fed. Rep. Germany
H. Ostertag

¹ From the Institute for Nuclear Medicine, German Cancer Research Center Heidelberg, Fed. Rep. Germany
W. Kübler

¹ From the Institute for Nuclear Medicine, German Cancer Research Center Heidelberg, Fed. Rep. Germany

Abstract

Continuous monitoring of cardiac output and sequential studies of right ventricular ejection fraction and of fractional myocardial uptake of substances with high cell affinity can be realized using ¹³N (t_1/2 = 9.6 min) and ^81mKr (t_1/2 = 13 sec). Thus, it is possible to measure rapid changes of absolute myocardial blood flow and of the inotropic state of the right heart myocardium. This is shown in patients who underwent interventions with Dipyridamole and with Dobutamine which produce a marked increase in myocardial blood flow or cardiac dynamics, respectively.

Die Verwendung von ¹³N (t_1/2 = 9.6 Min.) und ^81mKr (t_1/2 = 13 Sek.) erlaubt, das Verhalten des Herzzeitvolumens kontinuierlich aufzuzeichnen und Untersuchungen der rechtsventrikulären Ejektionsfraktion sowie der prozentualen Aufnahme von zellaffinen Substanzen durch das Myokard kurzfristig zu wiederholen. Dadurch ist es möglich, schnelle Veränderungen der Myokarddurchblutung und der rechtsventrikulären Funktion nachzuweisen. Dies wird an Patienten bestätigt, bei denen die Myokarddurchblutung mit Hilfe von Dipyridamol und die Kontraktionskraft des Herzens durch Dobutamin gesteigert wird.

Full Text

References

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Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects[*]

Authors

Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects^[*]