Investigation of the Parameters Related to the Formation of 99mTc-Pyrophosphate Complexes Using Gel Chromatography Column Scanning

Y. F. Shafiq; M. A. A. Al-Janabi; H. M. Al-Azzawi; M. A. A. Abdel-Azeez; M. H. S. Al-Hissoni; M. N. Jassim

doi:10.1055/s-0038-1624294

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1985; 24(03): 146-149
DOI: 10.1055/s-0038-1624294

Short Communications – Kurzmitteilungen

Schattauer GmbH

Investigation of the Parameters Related to the Formation of ^99mTc-Pyrophosphate Complexes Using Gel Chromatography Column Scanning

Untersuchung der Parameter zur Bildung von ^99mTc-Pyrophosphat-Komplexen mit Gelchromatographie-Säulen-Szintigraphie

Authors

Y. F. Shafiq

²From the Radioisotopes Production Dept., Nuclear Research Centre, Tuwaitha, Baghdad, Iraq
M. A. A. Al-Janabi

²From the Radioisotopes Production Dept., Nuclear Research Centre, Tuwaitha, Baghdad, Iraq
H. M. Al-Azzawi

²From the Radioisotopes Production Dept., Nuclear Research Centre, Tuwaitha, Baghdad, Iraq
M. A. A. Abdel-Azeez

²From the Radioisotopes Production Dept., Nuclear Research Centre, Tuwaitha, Baghdad, Iraq
M. H. S. Al-Hissoni

¹The Ibn Al-Nafis Cardiovascular Teaching Hospital, Baghdad, Iraq
M. N. Jassim

¹The Ibn Al-Nafis Cardiovascular Teaching Hospital, Baghdad, Iraq

Abstract

Summary

Using gel chromatography two different ^99mTc-PPi complexes (complex I and II) were observed under various pH-values. In neutral medium complex II was the main product while in acidic or alkaline media complexes

I and II were formed. Our results related to the organ distribution in mice revealed that complex II

is a bone-seeking agent whereas complex I concentrates in the kidneys.

Zusammenfassung

Bei Anwendung der Gelchromatographie wurden zwei verschiedene ^99mTc-PPi-Komplexe (Komplex I und II) bei verschiedenen pH-Werten beobachtet. Im neutralen Bereich war Komplex II das Hauptprodukt, während im sauren oder alkalischen Bereich Komplex I und II gebildet wurde. Anhand der Organverteilung in der Maus konnte gezeigt werden, daß der Komplex II ein knochensuchendes Agens ist, während Komplex I sich in der Niere anreichert.

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References

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