¹¹C Distribution in Dogs Visualized In Situ after Intravenous ¹¹C-Cyanide in High Specific Activity^[***]

Le cyanide-¹¹C peut être produit continuellement en centaines de milicuries par heure en irradiant un gaz composé de 99% d’azote et 1% d’hydrogène avec des protons de 15 MeV.

On a démontré in situ que la carbon 11 est fixé régulièrement dans le coeur, le fond de l’estomac et les reins de chiens en anesthésie profonde de pentobarbital entre quelques minutes et une heure après injection intraveineuse de ¹¹C-cyanide à activité spécifique élevée. En plus le carbon 11 est fixé dans les parotides et les testicules de quelques chiens mais pas régulièrement.

On developpe une hypothèse qui attribue ces résultats à la formation de H¹¹Cferricytochrome- oxidase dans les organes qui montrent une fixation élevée du ¹¹C.

Summary

¹¹C-cyanide is produced automatically and continuously, at the rate of hundreds of millicuries per hour, by bombarding gas targets consisting of 99% nitrogen and 1% hydrogen, with 15-MeV protons.

Carbon-11 is demonstrated in situ to localize regularly in the heart, fundus of the stomach, and the kidneys of dogs under deep pentobarbital anesthesia, within minutes to an hour after intravenously injecting ¹¹C-cyanide in high specific activity. Additionally, Carbon-11 accumulates similarly in the parotid glands or in the testes of some of the dogs, but these are inconstant findings.

An hypothesis is developed that attributes the results to the formation of H¹¹CN-ferricytochrome oxidase in the organs and tissues where high Carbon-11 uptake occurs.

Beobachtungen in Situ nach intravenöser Verabreichung von ¹¹C-2yanid von hoher spezifischer Aktivität

¹¹C-2yanid kann automatisch und kontinuierlich zu Hunderten von Millicuries pro Stunde durch Beschuß von Gas, das aus 99% Stickstoff und l% Wasserstoff besteht, mit 15-MeV Protonen erzeugt werden.

Es kann in Situ nachgewiesen werden, daß ¹¹C regelmäßig im Herzen, Magenfundus und in den Nieren von Hunden in tiefer Barbituratnarkose aufgenommen wird, und zwar innerhalb Minuten bis zu einer Stunde nach intravenöser Injektion von ¹¹C-Zyanid von hoher spezifischer Aktivität. Zusätzlich wird ¹¹C in ähnlicher Weise auch in der Parotis und in den Hoden eines Teiles der Hunde gespeichert, doch ist dies nicht immer der Fall.

Es wird eine Hypothese entwickelt, die diese Ergebnisse der Bildung von H¹¹CN-Eisenzytochromoxidase in jenen Organen zuschreibt, die eine hohe ¹¹CSpeicherung aufweisen.

^* Donner Laboratory, University of California at Berkeley and Medi-Physics, Inc., Emeryville, California.

^** This work was supported under AEC contract W-7405-ENG-48 and At(04-3)-849.

^*** visi ing Professor of Nuclear Medicine from the Department of Radiology at The Ohio State University, Columbus, Ohio.

^**** National Institutes of Health Trainee in Nuclear Medicine.

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