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Nuklearmedizin 1974; 13(02): 139-143
DOI: 10.1055/s-0038-1624850
Originalarbeiten — Original Articles
Schattauer GmbH

A Comparison of the Bone Seeking Properties of Short-Chained 99mTc-Sn-Polyphosphates

Ein Vergleich der „Knochensucher“-Eigenschaften von 99mTc-Sn-Polyphosphaten mit kurzer Kette
C. Schümichen
1   From the Clinical Laboratory and Laboratory for Nuclear Medicine of the Norwegian Radium Hospital, Oslo
,
K. F. Nakken
1   From the Clinical Laboratory and Laboratory for Nuclear Medicine of the Norwegian Radium Hospital, Oslo
› Author Affiliations
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Publication History

Received:03 April 1974

Publication Date:
12 January 2018 (online)

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Summary

The bone seeking properties of short-chained 99mTc-Sn-polyphosphates were studied in rats. The average chain lengths of the polyphosphates ranged from n = 2 to n = 6. 85Sr was used as a standard for comparison. There was a trend of less bone uptake as well as higher soft tissue and blood concentration with increasing chain length. This and the results of clinical studies indicate that of all 99mTc-Sn-polyphosphates investigated the pyrophosphate complex is the most suitable one for skeletal imaging.

Kurzkettige 99mTc-Sn-Polyphosphate wurden auf ihre Eignung zur Knochenszintigraphie hin an Ratten untersucht. Die mittleren Kettenlängen reichten von n = 2 bis n = 6. Als Vergleichsstandard wurde 85Sr herangezogen. Mit zunehmender Kettenlänge verringerte sich die Aufnahme in den Knochen, ebenso wie sich die Weichteil- und Blutkonzentration erhöhte. Dies und die Ergebnisse klinischer Untersuchungen zeigen, daß von allen untersuchten 99mTc-Sn-Poly-phosphaten der Pyrophosphatkomplex am besten für die Knochenszintigraphie geeignet ist.

 

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