Erektile Dysfunktion und schlafbezogene Atmungsstörungen

Dauerhafte Probleme, eine für einen befriedigenden Geschlechtsverkehr ausreichende Erektion zu erlangen oder aufrecht zu erhalten (Erektile Dysfunktion, F52.2, ICD-10), können die Lebensqualität der Betroffenen stark beeinträchtigen. Die erektile Dysfunktion ist darüber hinaus ein Indikator für die endotheliale Dysfunktion und kardiovaskuläre Erkrankungen. Ähnliches gilt für schlafbezogene Atmungsstörungen, die auf neurogener, hormoneller und endothelialer Ebene zur erektilen Dysfunktion beitragen können.

• Literatur

• 1 Braun M, Wassmer G, Klotz T. et al. Epidemiology of erectile dysfunction: results of the „Cologne Male Survey“. Int J Impot Res 2000; 12: 305-311.
• 2 Guiliano F. et al. Prevalence of erectile dysfunction: results of an epidemiological survey of a representative sample of 1004 men. Eur Urol 2002; 42: 382-389.
• 3 Derouet H, Osterhage J, Sittinger H. [Erectile function disorders. Epidemiology, physiology, etiology, diagnosis and therapy]. Nervenarzt 2004; 75: 595-605 quiz 606–607.
• 4 Budweiser S, Enderlein S, Jörres RA. et al. Sleep apnea is an independent correlate of erectile and sexual dysfunction. J Sex Med 2009; 6: 3147-3157.
• 5 Lue TF. Erectile dysfunction. NEJM 2000; 342: 1802-1813.
• 6 Dean RC, Lue TF. Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Urol Clin North Am 2005; 32: 379-v.
• 7 Lee W, Nagubadi S, Kryger MH, Mokhlesi B. Epidemiology of Obstructive Sleep Apnea: a Population-based Perspective. Expert Rev Respir Med 2008; 2: 349-364.
• 8 Somers VK, White DP, Amin R. et al. Sleep apnea and cardiovascular disease. Circulation 2008; 118: 1080-1111.
• 9 Somers VK. et al. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995; 96: 1897-1904.
• 10 Fanfulla F, Malaguti S, Montagna T. et al. Erectile dysfunction in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep 2000; 23: 775-781.
• 11 Mayer P. et al. Peripheral neuropathy in sleep apnea. A tissue marker of the severity of nocturnal desaturation. Am J Respir Crit Care Med 1999; 159: 213-219.
• 12 Luboshitzky R, Herer P, Levi M. et al. Relationship between rapid eye movement sleep and testosterone secretion in normal men. J Androl 1999; 20: 731-737.
• 13 Luboshitzky R. et al. Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab 2001; 86: 1134-1139.
• 14 Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med 2002; 165: 934-939.
• 15 Minoguchi K. et al. Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea. Am J Respir Crit Care Med 2005; 172: 625-630.
• 16 Schulz R. et al. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 2000; 55: 1046-1051.
• 17 Drager LF, Bortolotto LA, Figueiredo AC. et al. Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 2007; 176: 706-712.
• 18 Montorsi F, Briganti A, Salonia A. et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003; 44: 360-364 discussion 364–365.
• 19 Solomon H, Man JW, Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251-253.
• 20 Kaiser DR. et al. Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004; 43: 179-184.
• 21 Blumentals WA, Gomez-Caminero A, Joo S, Vannappagari V. Is erectile dysfunction predictive of peripheral vascular disease?. Aging Male 2003; 6: 217-221.
• 22 Blumentals WA, Gomez-Caminero A, Joo S, Vannappagari V. Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study. Int J Impot Res 2004; 16: 350-353.
• 23 Leitlinien für Diagnostik und Therapie in der Neurologie; 4. überarbeitete Auflage. Stuttgart: Georg Thieme Verlag; 2008: 654 ff.
• 24 Budweiser S, Luigart R, Jörres RA. et al. Long-term changes of sexual function in men with obstructive sleep apnea after initiation of continuous positive airway pressure. J Sex Med 2013; 10: 524-531
• 25 Li X, Dong Z, Wan Y, Wang Z. et al. Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a meta-analysis. Aging Male 2010; 13: 82-86