Pestwurz in der Behandlung der Migräne

S. Evers

doi:10.1055/s-0038-1628674

Nervenheilkunde, Table of Contents

Nervenheilkunde 2009; 28(08): 548-552
DOI: 10.1055/s-0038-1628674

Übersichtsarbeit

Schattauer GmbH

Pestwurz in der Behandlung der Migräne

Eine ÜbersichtPetasites in the treatment of migraineA review

S. Evers

¹Klinik und Poliklinik für Neurologie, Universitätsklinikum Münster

› Author Affiliations

Abstract

Zusammenfassung

Pestwurz wird in der Medizingeschichte seit der Antike als Heilpflanze bei verschiedenen Indikationen eingesetzt. In den letzten Jahren sind die biochemischen Mechanismen der Wirkung von Pestwurz teilweise aufgeklärt worden. Zuletzt hat sich klinisch insbesondere die Indikation Migräneprophylaxe durchgesetzt und ist mit den Verfahren der evidenzbasierten Medizin untersucht worden. Dabei hat sich in zwei Studien konsistent eine Wirksamkeit in der Migräneprophylaxe gezeigt. Der signifikante Unterschied zu Placebo in der Responderrate lag dabei zwischen 19 und 30%. Am häufigsten sind gastrointestinale Nebenwirkungen. Erhöhungen von Leberenzymen durch die Einnahme von Pestwurz sind kontrovers diskutiert worden. In placebokontrollierten Studien lag die Rate der reversiblen Leberwerterhöhungen unter 10%; in dem Melderegister der Nebenwirkungen sind bei geschätzten 75 000 Patientenjahren sechs Fälle eines möglichen oder wahrscheinlichen Zusammenhangs der Einnahme von Pestwurz und Lebererkrankungen dokumentiert.

Summary

Petasites has been used in the history of medicine since antiquity in different indications. In the past years, even some biochemical mechanisms of the therapeutic efficacy of petasites have been detected. In particular, migraine prophylaxis as an indication for petasites has been investigated in evidence-based trials. Two placebo controlled trials have shown consistently an efficacy of petasites in migraine prophylaxis. The significant difference to placebo was between 19 and 30% with respect to responder rate. The most frequent side effects of petasites are gastrointestinal complaints. Elevation of liver enzymes caused by petasites have been discussed controversy. In the placebo controlled trials, the rate of reversible elevation of liver enzymes was lower than 10%. In the register of all reported adverse events,six 6 cases of a liver disease with a possible or probable causal relationship to the intake of petasites have been documented.

Schlüsselwörter

Migräne - Pestwurz - Prophylaxe

Keywords

Migraine - petasites - prophylaxis

Full Text

References

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