Kinder- und Jugendmedizin 2015; 15(03): 170-177
DOI: 10.1055/s-0038-1629268
Pneumologie
Schattauer GmbH

Chirurgische Therapie des Pleuraempyems bei Kindern

Surgical management of pleural empyema in children
J. Dingemann
1   Zentrum Kinderchirurgie Hannover, Kinderchirurgische Klinik der Medizinischen Hochschule Hannover, Kinderchirurgie/Kinderurologie Auf der Bult, Hannover
,
N. Schwerk
2   Zentrum Kinderheilkunde und Jugendmedizin, Klinik für Pädiatrische Pneumonologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover
,
O. Madadi-Sanjani
1   Zentrum Kinderchirurgie Hannover, Kinderchirurgische Klinik der Medizinischen Hochschule Hannover, Kinderchirurgie/Kinderurologie Auf der Bult, Hannover
,
B. M. Ure
1   Zentrum Kinderchirurgie Hannover, Kinderchirurgische Klinik der Medizinischen Hochschule Hannover, Kinderchirurgie/Kinderurologie Auf der Bult, Hannover
› Author Affiliations
Further Information

Publication History

Eingereicht am: 23 January 2015

angenommen am: 05 February 2015

Publication Date:
29 January 2018 (online)

Zusammenfassung

Das Pleuraempyem ist definiert als infizierter parapneumonischer Erguss in der Pleurahöhle. Durch die Aktivierung der Gerinnungskaskade kommt es zu ausgeprägter Fibrinabscheidung mit Septierung und Kammerung der Pleurahöhle. Die Einteilung des Pleuraempyems erfolgt nach Größe und Stadium. Die Diagnosestellung erfolgt radiologisch und sonografisch. Alle großen (sonografisch >2 cm) Pleuraempyeme Stadium I sollten drainiert werden. Die Primärtherapie der Wahl des Pleuraempyems Stadium II ist die fibrinolytische Therapie über eine Thoraxdrainage. Kleinlumige Pigtaildrainagen sind dabei den konventionellen, großlumigen Thoraxdrainagen gleichgestellt. Bei Therapieversagen muss eine thorakoskopische Ausräu-mung des Pleuraempyems in Erwägung gezogen werden. Für die Therapie des Pleuraempyem Stadium III kann keine evidenzbasierte Empfehlung ausgesprochen werden. Die Indikation zur Thorakotomie und Dekortikation wird symptomabhängig gestellt. Da die Indikation zur chirurgischen Therapie häufig kurzfristig gestellt werden muss, ist eine interdisziplinäre Betreuung der Patienten vom Zeitpunkt der Diagnosestellung an obligat.

Summary

Pleural empyema is defined as infected parapneumonic effusion of the pleural cavity. Activation of the coagulation cascade leads to deposition of fibrin and purulent material followed by fibrinous loculations and septations of the pleura. The main criteria for classification of pleural empyema are size and stage of the disease. Chest X-ray and sonography are the most important imaging modalities to diagnose pleural empyema. All large (>2 cm) pleural effusions should be drained. The primary therapy of pleural empyema stage II is fibrinolysis which is applied through a chest tube. Small bore pigtail chest tubes do not bear any disadvantages as compared to conventional surgical thoracic drains. If failure of fibrinolytic therapy occurs, thoracoscopic debridement needs to be done. No evidence based recommendation can be given for pleural empyema stage III. The indication for thoracotomy and decortication should be made according to the severity of symptoms. A primary interdisciplinary approach is mandatory, since the indication for surgical therapy of pleural empyema may be given at any stage of the disease.

 
  • Literatur

  • 1 Burgos J, Falcó V, Pahissa A. The increasing incidence of empyema. Curr Opin Pulm Med 2013; 19: 350-356.
  • 2 Hendriks J, Sabbe M, Verhaegen J. et al. Pleural empyema in children. Eur Respir Monogr 2013; 61: 153-161.
  • 3 Grijalva CG, Nuorti JP, Zhu Y, Griffin MR. Increasing incidence of empyema complicating childhood community-acquired pneumonia in the United States. Clin Infect Dis 2010; 50: 805-813.
  • 4 Tan TQ, Mason Jr EO, Wald ER. et al. Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics 2002; 110: 1-6.
  • 5 Cohen E, Mahant S, Dell SD. et al. The long-term outcomes of pediatric pleural empyema: a prospective study. Arch Pediatr Adolesc Med 2012; 166: 999-1004.
  • 6 Grijalva CG, Zhu Y, Nuorti JP, Griffin MR. Emergence of parapneumonic empyema in the USA. Thorax 2011; 66: 663-668.
  • 7 Balfour-Lynn IM, Abrahamson E, Cohen G. et al. Paediatric Pleural Diseases Subcommittee of the BTS Standards of Care Committee. BTS guidelines for the management of pleural infection in children. Thorax 2005; 60 (Suppl. 01) Suppl i1-21.
  • 8 Brixey AG, Luo Y, Skouras V. et al. The efficacy of chest radiographs in detecting parapneumonic effusions. Respirology 2011; 16: 1000-1004.
  • 9 Calder A, Owens CM. Imaging of parapneumonic pleural effusions and empyema in children. Pediatr Radiol 2009; 39: 527-537.
  • 10 Kurian J, Levin TL, Han BK. et al. Comparison of ultrasound and CT in the evaluation of pneumonia complicated by parapneumonic effusion in children. AJR Am J Roentgenol 2009; 193: 1648-1654.
  • 11 Carter E, Waldhausen J, Zhang W. et al. Management of children with empyema: Pleural drainage is not always necessary. Pediatr Pulmono 2010; 45: 475-480.
  • 12 Islam S, Calkins CM, Goldin AB. et al. APSA Outcomes and Clinical Trials Committee, 2011-2012. The diagnosis and management of empyema in children: a comprehensive review from the APSA Outcomes and Clinical Trials Committee. J Pediatr Surg 2012; 47: 2101-2110.
  • 13 Stringel G, Hartman AR. Intrapleural instillation of urokinase in the treatment of loculated pleural effusions in children. J Pediatr Surg 1994; 29: 1539-1540.
  • 14 Rosen H, Nadkarni V, Theroux M. et al. Intrapleural streptokinase as adjunctive treatment for persistent empyema in pediatric patients. Chest 1993; 103: 1190-1193.
  • 15 Ray TL, Berkenbosch JW, Russo P, Tobias JD. Tissue plasminogen activator as an adjuvant therapy for pleural empyema in pediatric patients. J Intensive Care Med 2004; 19: 44-50.
  • 16 Yao CT, Wu JM, Liu CC. et al. Treatment of complicated parapneumonic pleural effusion with intrapleural streptokinase in children. Chest 2004; 125: 566-571.
  • 17 Misthos P, Sepsas E, Konstantinou M. et al. Early use of intrapleural fibrinolytics in the management of postpneumonic empyema. A prospective study. Eur J Cardiothorac Surg 2005; 28: 599-603.
  • 18 Kiliç N, Celebi S, Gürpinar A. et al. Management of thoracic empyema in children. Pediatr Surg In 2002; 18: 21-23.
  • 19 Cameron R, Davies HR. Intra-pleural fibrinolytic therapy versus conservative management in the treatment of adult parapneumonic effusions and empyema. Cochrane Database Syst Rev 2008; 2: CD002312
  • 20 Light RW, Nguyen T, Mulligan ME, Sasse SA. The in vitro efficacy of varidase versus streptokinase or urokinase for liquefying thick purulent exudative material from loculated empyema. Lung 2000; 178: 13-18.
  • 21 Bouros D, Schiza S, Patsourakis G. et al. Intrapleural streptokinase versus urokinase in the treatment of complicated parapneumonic effusions: a prospective, double-blind study. Am J Respir Crit Care Med 1997; 155: 291-295.
  • 22 Sonnappa S, Cohen G, Owens CM. et al. Comparison of urokinase and video-assisted thoracoscopic surgery for treatment of childhood empyema. Am J Respir Crit Care Med 2006; 174: 221-227.
  • 23 St Peter SD, Tsao K, Spilde TL. et al. Thoracoscopic decortication vs tube thoracostomy with fibrinolysis for empyema in children: a prospective, randomized trial. J Pediatr Surg 2009; 44: 106-111. discussion 111
  • 24 Martin K, Emil S, Zavalkoff S. et al. Transitioning from stiff chest tubes to soft pleural catheters: prospective assessment of a practice change. Eur J Pediatr Surg 2013; 23: 389-393.
  • 25 Lin CH, Lin WC, Chang JS. Comparison of pigtail catheter with chest tube for drainage of parapneumonic effusion in children. Pediatr Neonatol 2011; 52: 337-341.
  • 26 Bishay M, Short M, Shah K. et al. Efficacy of video-assisted thoracoscopic surgery in managing childhood empyema: a large single-centre study. J Pediatr Surg 2009; 44: 337-342.
  • 27 Goldin AB, Parimi C, LaRiviere C. et al. Outcomes associated with type of intervention and timing in complex pediatric empyema. Am J Surg 2012; 203: 665-673.
  • 28 Schneider CR, Gauderer MW, Blackhurst D. et al. Video-assisted thoracoscopic surgery as a primary intervention in pediatric parapneumonic effusion and empyema. Am Surg 2010; 76: 957-961.
  • 29 Kurt BA, Winterhalter KM, Connors RH. et al. Therapy of parapneumonic effusions in children: video-assisted thoracoscopic surgery versus conventional thoracostomy drainage. Pediatrics 2006; 118: e547-553.
  • 30 Cobanoglu U, Sayir F, Bilici S, Melek M. Comparison of the methods of fibrinolysis by tube thoracostomy and thoracoscopic decortication in children with stage II and III empyema: a prospective randomized study. Pediatr Rep 2011; 3: e29
  • 31 Mahant S, Cohen E, Weinstein M, Wadhwa A. Video-assisted thorascopic surgery vs chest drain with fibrinolytics for the treatment of pleural empyema in children: a systematic review of randomized controlled trials. Arch Pediatr Adolesc Med 2010; 164: 201-203.
  • 32 Chan W, Keyser-Gauvin E, Davis GM. et al. Empyema thoracis in children: a 26-year review of the Montreal Children’s Hospital experience. J Pediatr Surg 1997; 32: 870-872.
  • 33 Grotenhuis BA, Janssen PJ, Eerenberg JP. The surgical treatment of stage III empyema: the effect on lung function. Minerva Chir 2008; 63: 23-27.
  • 34 Menon P, Rao KL, Singh M. et al. Surgical management and outcome analysis of stage III pediatric empyema thoracis. J Indian Assoc Pediatr Surg 2010; 15: 9-14.