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Vet Comp Orthop Traumatol 2002; 15(02): 67-71
DOI: 10.1055/s-0038-1632716
DOI: 10.1055/s-0038-1632716
Original Research
Biomarkers of bone metabolism in horses: Ante-mortem versus post-mortem correlation in serum and aqueous humour
This work was supported by the State of Indiana and Purdue University School of Veterinary Medicine Research account funded by the Total Wagers Tax.
Further Information
Publication History
Received
20 June 2001
Accepted
23 August 2001
Publication Date:
07 February 2018 (online)
Summary
The objective of this study was to determine the correlation between ante-mortem and 24-hour postmortem concentrations of four markers of bone metabolism in equine serum and aqueous humour. The markers evaluated were osteocalcin, bone alkaline phosphatase, carboxyterminal propeptide of type-1 procollagen and carboxyterminal cross-linked telopeptide of type-1 collagen (ICTP). The concentrations of these markers were poorly correlated (P > 0.05) between aqueous humour and serum. ICTP was the only serum marker significantly correlated (r = 0.93) between ante- and post-mortem samples. ICTP is, therefore, a potential marker for evaluating antemortem markers of bone metabolism in dead horses.
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