Multiple cartilaginous exostosis in a Golden Retriever cross-bred puppy

Summary

Multiple cartilaginous exostosis was diagnosed in a sixmonth-old Golden Retriever cross-bred male with a history of forelimb lameness and isolated, but very painful, acute episodes. Physical examination revealed a right forelimb lameness with a firm, painful palpable mass on the cranial aspect of the forearm. The radiological examination showed the presence of bony masses at the humerus and radius as well as several masses in the ribs and spinous processes of the thoracic vertebrae. Based on the history and radiographic findings, multiple cartilaginous exostosis was diagnosed. Treatment with non-steroidal anti-inflammatory drugs was commenced for two weeks without any effect. Due to the lack of a response to the treatment as well as to the progressive physical deterioration of the animal, the owners requested euthanasia of the dog. Histology of the different exostoses demonstrated the presence of a hyaline cartilage cup surrounding a central area, formed mainly by bone and cartilage trabecullae. Signs of malignancy were not observed. Back-scattered scanning electron microscopy (BEI-SEM) study revealed well ordered and progressively calcified cartilage trabecullae present underneath the non-calcified cartilage cap. At a greater depth, those cartilage trabecullae became osteochondral trabecullae, and the innermost were formed exclusively by woven and lamellar bone. The histological and back-scattered electron scanning microscopy results conclude that it was a well-arranged normal endochondral ossification process that followed a centripetal pattern inside the bony mass, confirming the diagnoses of multiple cartilaginous exostoses.

Keywords

Multiple cartilaginous exostoses - dog

• References

• 1 Beck JA, Simpson DJ, Tisdall PL. Surgical management of osteochondromatosis affecting the vertebrae and trachea in an Alaskan Malamute. AustrVet J 1999; 77: 21-3.
• 2 Caporn TM, Read RA. Osteochondromatosis of the cervical spine causing compressive myelopathy in a dog. J Small Anim Pract 1996; 37: 133-7.
• 3 Chester DK. Multiple Cartilaginous Exostoses in two generations of dogs. J Am Vet Med Assoc 1971; 159: 895-7.
• 4 Doige CE, Pharr JW, Withrow SJ. Chondrosarcoma arising in multiple cartilaginous exostoses in a dog. JAmAnimHosp Assoc 1978; 14: 605-11.
• 5 Franch J, Garcia F, Camón J. et al. Backscattered electron imaging of the calcified tissues present in bone healing. Vet Comp Orthop Traumatol 1998; 2: 105-11.
• 6 Gambardella PC, Osborne CA, Stevens JB. Multiple Cartilaginous Exostoses in the Dog. J Am Vet Med Assoc 1975; 166: 761-8.
• 7 Gee BR, Doige CE. Multiple Cartilaginous Exostoses in a Litter of Dogs. J Am Vet Med Assoc 1970; 156: 53-9.
• 8 Green EM, Admas WM, Steinberg H. Malignant transformation of solitary spinal osteochondroma in two mature dogs. Vet Radiol Ultrasound 1999; 40: 634-7.
• 9 Jacobson LS, Kirberger RM. Canine Multiple Cartilaginous Exostoses: Unusual manifestations and a review of the literature. J Am Anim Hosp Assoc 1996; 32: 45-51.
• 10 Kivioja A, Ervasti H. Kinnunen et al. Chondrosarcoma in a family with multiple hereditary exostoses. J Bone Joint Surg (B) 2000; 82: 261-6.
• 11 Morgan JP, Stavenborn M. Disseminated idiopathic skeletal hyperostosis (DISH) in a dog. Vet Radiol Ultrasound 1991; 32: 60-5.
• 12 Mozos E, Novales M, Ginel P. et al. Anewly recognized pattern of canine osteochondromatosis. Vet Radiol Ultrasound 2002; 43: 132-7.
• 13 Pool RR, Carrig CB. Multiple cartilaginous exostoses in a cat. Vet Pathol 1972; 9: 350-9.
• 14 Pool RR. Osteochondromatosis. In: Bojrab MJ, Smeak DD, Bloomberg MS. eds Disease Mechanism in Small Animal Surgery. Philadelphia: Lippincott Williams & Wilkins,; 1993: 821-33.
• 15 Prata RG, Stoll SG, Zaki FA. Spinal cord compression caused by osteocartilaginous exostoses in two dogs. J Am Vet Med Assoc 1975; 166: 371-5.
• 16 Quirini G, Meyer J, Herman M. et al. Osteochondroma of the thoracic spine: an unusual cause of spinal cord compression. Am J Neuroradiol 1996; 17: 961-4.
• 17 Shupe JL, Leone NC, Olson AE. et al. Hereditary multiple exostoses: Clinicopathologic features of a comparative study in horses and man. Am J Vet Res 1979; 40: 751-7.
• 18 Watson ADJ. Diseases of muscle and bone. In: Whitick WG. ed Canine Orthopedics. Philadelphia: Lea & Febiger,; 1990: 674-5.
• 19 Yamamoto T, Tanaka K, Nagira K. et al. Intermittent radial nerve palsy caused by a humeral osteochondroma: a case report. J Shoulder Elbow Surg 2002; 11: 92-4.
• 20 Zak BM, Crawford BE, Esko JD. Hereditary multiple exostoses and heparan sulfate polymerization. Biochim Biophys Acta 2002; 1573: 346-55.