Thromb Haemost 1974; 32(02/03): 266-276
DOI: 10.1055/s-0038-1647697
Original Article
Schattauer GmbH

Fibrinogen-Fibrin-Related Antigen Pattern in Human Blood

Differences between Plasma and Serum from Patients with Disseminated Intravascular Coagulation
Carl D. Jacobsen
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
,
John C. Hoak
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
,
Kenneth K. WU
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
,
Glenna L. Fry
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
› Author Affiliations
Further Information

Publication History

Received 08 October 1973

Accepted 10 June 1974

Publication Date:
30 June 2018 (online)

Preview

Summary

In serum from patients with DIC at least 3 different FR-antigenic components could be found. It was difficult to demonstrate these components in the corresponding plasma samples. It is possible that a portion of these antigens formed as a result of in vitro clotting despite the presence of proteolytic inhibitors. These results suggest that the interpretation of “increased split products in serum” may be more complex than current concepts indicate.