Fibrinoyltic Activity of Human Carcinomas

Summary

The fibrinolytic activity of 25 human malignant tumour specimens was studied by a semi-quantitative histochemical method and by a plasminogen activator extraction procedure. A good accordance between the results obtained with the two methods was found. The advantages and disadvantages of the methods are discussed.

• References

• 1 Astrup T, and Albrechtssen O. K. 1957; Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues. Scandinavian Journal of Clinical and Laboratory Investigation 9: 233.
• 2 Berg W, Korsan-Bengtsen K, and Ygge J. 1966; Human and bovine plasminogen-free thrombin purified by means of gel filtration and ion exchange chromatography. Thrombosis et Diathesis Haemorrhagica 15: 501.
• 3 Bkakman P. 1967. Fibrinolysis, a standarized fibrin plate method and a fibrinolytic assay of plasminogen. Scheltema & Holkema; Amsterdam:
• 4 Pandolfi M, Nilsson I. M, Robertson B, and Isacsson S. 1967; Fibrinolytic activity of human veins. Lancet 11: 127.
• 5 Peterson H.-I. 1968 Experimental studies on fibrinolysis in growth and spread of tumour. Acta Chirurgica Scandinavica, Suppl. 394.
• 6 Peterson H.-I, and Zettergren L. 1970; Thromboplastic and fibrinolytic properties of three transplantable rat tumours. Acta Chirurgica Scandinavica 136: 365.
• 7 Peterson H.-I, Kjartansson L, Korsan-Bengtsen K, Rudenstam C.-M, and Zettergren L. 1973; Fibrinolysis in human malignant tumours. Acta Chirurgica Scandinavica 139: 219.
• 8 Petrusson B. 1973 A micromethod for determination of tissue plasminogen activators in human mucosa. To be published.
• 9 Todd A.S. 1958; Fibrinolysis autographs. Nature (London) 181: 495.
• 10 Todd A. S. 1959; The histological localisation of fibrinolysin activator. Journal of Pathology and Bacteriology 78: 281.
• 11 Rybo G. 1966 Plasminogen activators in the endometrium. Acta Obstetrica et Gynecologica Scandinavica. Suppl. 7.