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Thromb Haemost 1974; 31(01): 040-051
DOI: 10.1055/s-0038-1649144
Original Article
Schattauer GmbH

Immunological Studies on the Blood Coagulation Factor X and Its Warfarin-induced Precursor

Gustav Gaudernack
1   Institute of Medical Biology, University of Tromso, Tromsø, Norway
,
Åse Gladhaug Berre
1   Institute of Medical Biology, University of Tromso, Tromsø, Norway
,
Bjarne Østerud
1   Institute of Medical Biology, University of Tromso, Tromsø, Norway
,
Hans Prydz
1   Institute of Medical Biology, University of Tromso, Tromsø, Norway
› Author Affiliations
Further Information

Publication History

Received 20 July 1973

Accepted 20 October 1973

Publication Date:
29 June 2018 (online)

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Summary

Monospecific antisera against the human coagulation factor X have been raised in rabbits by injections of purified antigen. Such antiserum was used to study the cross-reacting material without factor X activity which is present in the blood of warfarin-treated patients and animals as well as to study the changes in factor X during coagulation. One patient with congenital factor X deficiency was also studied.

A complete identity was found between factor X in Macaca mulatta and human blood. During warfarin treatment antigenically cross-reacting material appeared in plasma. This was not adsorbed on BaSO4, and inhibited the coagulation activity of normal factor X.

Both this material, normal factor X and the cross-reacting material in plasma from a patient congenitally deficient in factor X gave rise to split products during coagulation by the intrinsic pathway, i. e. all of them served as substrates for the intrinsic activator of factor X.

 

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