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Thromb Haemost 1968; 19(03/04): 570-577
DOI: 10.1055/s-0038-1651236
Originalarbeiten – Original Articles – Travaux Originaux
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Experimental Thrombocytopenia Induced by Busulphan (Myleran) in Rabbits: Extremely Low Platelet Levels and Intact Plasma Clotting System[*]

S. A Evensen
1   Section of Haematology (Head: P. F. Hjort), Medical Department A, Rikshospitalet, Oslo, Norway
,
M Jeremic
1   Section of Haematology (Head: P. F. Hjort), Medical Department A, Rikshospitalet, Oslo, Norway
,
P. F Hjort
1   Section of Haematology (Head: P. F. Hjort), Medical Department A, Rikshospitalet, Oslo, Norway
› Author Affiliations
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Publication Date:
27 June 2018 (online)

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Summary

The effects of 2 intraperitoneal injections of the alkylating agent Busulphan (each of 25 mg/kg body weight, 3 days between injections) on the circulating elements of the blood and on the plasma coagulation system in rabbits have been investigated.

Platelets fell progressively after a lag-phase of 7 days, reached a mean minimum level of about 3 % of the pre-injection level in 14 days, and then returned slowly towards normal values. Bleeding was an occasional complication and a rare cause of death. Granulocytopenia developed synchronously with the fall in platelets. The plasma clotting factors remained intact.

We conclude that this is a useful experimental model for studies on the role of platelets in hemostasis and thrombosis.

* Supported by The Norwegian Research Council for Science and the Humanities and by the Norwegian Council on Cardiovascular Diseases.


 

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