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Thromb Haemost 1971; 25(01): 142-146
DOI: 10.1055/s-0038-1654288
Originalarbeiten – Original Articles – Travaux Originaux
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The Effect of Intravascular and Extravascular Coagulation on Serum Fibrin Degradation Products in Rats

J. C Van Stone
1   Department of Medicine, Chicago Wesley Memorial Hospital, Northwestern University Medical Center, Chicago, Illinois
,
N. Y Khoury
1   Department of Medicine, Chicago Wesley Memorial Hospital, Northwestern University Medical Center, Chicago, Illinois
› Author AffiliationsThis work supported in part by the Department of Medicine, Education Fund, Chicago Wesley Memorial Hospital and a grant from Blood Research, Incorporated.
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

Serum fibrin degradation products (FDP) were elevated following intravascular clotting in rats. The levels of these products were similar whether the blood clot remained localized in the inferior vena cava or embolized to the lung. The level of FDP increased with increasing amounts of blood clot formed. The intravascular injection of 100 u of thrombin induced high levels of FDP and resulted in death of the animals. Extravascular deposition of fibrin, either subcutaneously, intramuscularly or intraperitoneally had no effect on serum FDP.

 

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