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Thromb Haemost 1967; 18(01/02): 259-267
DOI: 10.1055/s-0038-1655034
DOI: 10.1055/s-0038-1655034
Originalarbeiten — Original Articles — Travaux Originaux
The Formation and “Decay” of Xlla[*]
Further Information
Publication History
Publication Date:
26 June 2018 (online)
Summary
Various materials and conditions have been investigated for their effect on Hageman factor activation. Fatty acid soaps, purified phospholipids, ellagic acid, platelets, and freezing and thawing were among those studied.
Under certain circumstances XIIa activity disappeared spontaneously; the factors affecting the kinetics of this “decay” have been evaluated. Successful regeneration of this “decayed” XII a has been achieved. On the basis of these observations, it is postulated that during its “decay”, XIIa reverts to XII by spontaneous molecular refolding.
* Supported in part by U.S.P.H.S. Grant HE 09918 and be donations from Mrs. Kathryn English.
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