The Fibrinolytic System in South African White and Bantu Men

H Lackner; A. J Johnson

doi:10.1055/s-0038-1655055

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1967; 18(03/04): 456-461
DOI: 10.1055/s-0038-1655055

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

The Fibrinolytic System in South African White and Bantu Men

Authors

H Lackner M. D.

¹Department of Medicine, University of Cape Town Medical School and Groote Schuur Hospital, Observatory, Cape, South Africa, and from the Department of Medicine and the American National Red Cross Research Laboratory, New York University Medical Center, New York
A. J Johnson M. D.

¹Department of Medicine, University of Cape Town Medical School and Groote Schuur Hospital, Observatory, Cape, South Africa, and from the Department of Medicine and the American National Red Cross Research Laboratory, New York University Medical Center, New York

Abstract

Summary

1. In a study of fibrinolytic activity conducted among South African Bantus and white males, the Bantus were found to have greater fibrinolytic activity, primarily because of higher levels of plasminogen activator.

2. Levels of fibrinolytic inhibitors were similar in the 2 groups.

3. The plasminogen level was significantly higher in the Bantus than in the South African whites, but it could not be correlated with fibrinolytic activity in individual subjects.

4. Differences in serum protein patterns of Bantus and whites were confirmed.

Full Text

References

References
1 Abramson J. H, Gampel B, Scotch N, Slome C. Diet and serum protein levels of urban Zulu adults. Brit. J. prev. soc. Med. 14: 190 1960;
2 Astrup T. Role of blood coagulation and fibrinolysis in the pathogenesis of arteriosclerosis. In: Connective Tissue, Thrombosis and Atherosclerosis. Ed. by I. H. Page. 223 Academic Press; New York: 1959
3 Back N, Ambrus C. M, Ambrus J. L, Munson A. E, Lassman H. B. Role of red blood cells in fibrinolysis. Abstract. Fed. Proc. 23: 354 1964;
4 Bradlow B. A, Antonis A, Bersohn I. Fibrinolytic activity in South African Bantu and white male subjects. S. Afr. J. med. Sci. 27: 15 1962;
5 Bronte-Stewart B, Antonis A, Rose-Innes G, Moodie A. D. An interracial study on the serum protein pattern of adult men in Southern Africa. Amer. J. clin. Nutr. 09: 596 1961;
6 Bronte-Stewart B, Keys A, Brock J. F, with the collaboration of Moodie A. D, Keys M. H, Antonis A. Serum-cholesterol, diet, and coronary heart-disease. An inter-racial survey in the Cape Peninsula. Lancet II: 1103 1955;
7 Clark E, Graef I, Chasis H. Thrombosis of the aorta and coronary arteries, with special reference to the “fibrinoid” lesions. Arch. Path. 22: 183 1936;
8 Colowick S. P, Kaplan N. D. Biuret method for protein determination. In: Methods in Enzymology. Vol. 3, 450 Academic Press; New York: 1957
9 Crawford T. Morphological aspects in the pathogenesis of atherosclerosis. J. Atheroscler. Res. 01: 3 1961;
10 Duguid J. B. Mural thrombosis in arteries. Brit. med. Bull. 11: 36 1955;
11 Edozien J. C. The development of the serum protein pattern in Africans. J. clin. Path. 14: 644 1961;
12 Fearnley G. R, Balmforth G, Fearnley E. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis. Clin. Sci. 16: 645 1957;
13 Franz R. G, Kark A. E, Hathorn M. Postoperative thrombosis and plasma fibrinolytic activity; a comparative study in Africans, Indians, and Whites. Lancet I: 195 1961;
14 Gillman T, Naidoo S. S, Hathorn M. Fat, fibrinolysis, and atherosclerosis in Africans. Lancet. II: 696 1957;
15 Holmes E. G, Stanier M. W, Semambo Y. B, Jones E. R. An investigation of serum proteins of Africans in Uganda, Trans, roy. Soc. trop. Med. Hyg. 45: 371 1951;
16 Howell M. Comparison of fibrinolysis and coagulation in Nigerian and European men. J. Atheroscler. Res. 05: 80 1965;
17 Johnson A. J, McCarty W. R, Tillett W. S, Tse A. O, Skoza L, Newman J, Semar M. Fibrinolytic, caseinolytic and biochemical methods for the study of thrombolysis in man: Application and standardization. In: Blood Coagulation, Hemorrhage and Thrombosis, Methods of Study. Ed. by Tocantins L. M, Kazal L. A. 449 Grune & Stratton; New York: 1964
18 Johnson A. J, Semar M, Skoza L. Isolation and preliminary characterization of a plasminogen activator from human erythrocytes. (Abstract G: 76) Proc. Xth Cong. Int. Soc. Haemat. Stockholm, Sweden: 1964
19 Joubert S. M, Hookins K. W, Hunter W. G. A comparative study of serum protein moieties in European, African and Indian adult populations of Durban. S. Afr. J. Lab. clin. Med. 05: 1 1959;
20 Lackner H, Goosen C. G. Fibrinolytic activity of blood; photographic determination of clot lysis time. Acta haemat. (Basel) 22: 58 1959;
21 Lackner H, Sougin-Mibashan R. Fibrinolysis and alimentary lipaemia in Whites and Bantus ; their relationship and response to intravenous heparin. Thrombos. Diathes. haemorrh. (Stuttg) 11: 108 1964;
22 Merskey G, Gordon H, Lackner H, with collaboration of Schrire V, Kaplan B. J, SouginMibashan R, Nossel H. L, Moodie A. Blood coagulation and fibrinolysis in relation to coronary heart disease ; a comparative study of normal white men, white men with overt coronary heart disease, and normal Bantu men. Brit. med. J. I: 219 1960;
23 Merskey G, Nossel H. L. Blood coagulation after the ingestion of saturated and unsaturated fats. Lancet I: 806 1957;
24 Pickering G. Pathogenesis of myocardial and cerebral infarction: nodular arteriosclerosis. Brit. med. J. 01: 517 1964;
25 Rimon A, Segal S. Streptokinase-induced proteolytic activity with respect to age in two ethnic groups in Israel. Thrombos. Diathes. haemorrh. (Stuttg) 11: 119 1964;
26 Robbins K. G, Summaria L. Purification of human plasminogen and plasmin by gel filtration on Sephadex and chromatography on diethylaminoethyl-Sephadex. J. biol. Chem. 238: 952 1963;
27 Rokitansky, Carl: A Manual of Pathological Anatomy (4 vol. bound in 2). Blanchard and Lea; Philadelphia: 1855
28 Vogelpoel L, Schrire V. Myocardial infarction; its racial incidence in Cape Town. Lancet II: 1108 1955;
29 von Kaulla K. N, Schultz R. L. Methods for the evaluation of human fibrinolysis; studies with combined technics. Amer. J. clin. Path. 29: 104 1958;