Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00034925.xml
Download PDF
Hamostaseologie 1989; 09(04): 215-226
DOI: 10.1055/s-0038-1655273
DOI: 10.1055/s-0038-1655273
Originalarbeiten
Die Rolle endothelialer Autakoide für Vasomotion und Hämostase
Authors
Further Information
Publication History
Publication Date:
25 June 2018 (online)
-
LITERATUR
- 1 Aalkjaer C, Heagerty A M, Swales J D, Thurston H. Endothelial-dependent relaxation in human subcutaneous resistance vessels. Blood Vessels 1987; 24: 85-8.
- 2 Aarts P A M M, Bolhuis P A, Sakariassen K S, Heethaar R M, Sixma J J. Red blood cell size is important for adherence of blood platelets to artery subendothelium. Blood 1983; 62: 214-7.
- 3 Aarts P A M M, Heethaar R M, Sixma J J. Red blood cell deformability influences platelet vessel wall interaction in flowing blood. Blood 1984; 64: 1228-33.
- 4 Albert D H, Snyder F. Biosynthesis of 1- alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2- acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. J Biol Chem 1983; 258: 97-102.
- 5 Anderson E A, Mark A L. Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation 1989; 79: 93-100.
- 6 Angus J A, Cocks T M. The half-life of endothelium-derived relaxing factor released from bovine aortic endothelial cells in culture. J Physiol 1987; 388: 71-81.
- 7 Arnoux B, Duval D, Benveniste J. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. Eur J Clin Invest 1980; 10: 437-41.
- 8 Azuma H, Ishikawa M, Sekizaki S. Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol 1986; 88: 411-5.
- 9 Bassenge E, Busse R. Endothelial modulation of coronary tone. Prog Cardiovasc Dis 1988; 30: 349-80.
- 10 Benveniste J, Henson P M, Cochrane C G. Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils and platelet-activating factor. J Exp Med 1972; 136: 1356-77.
- 11 Benveniste J, Vargaftig B B. Platelet activating factor: an ether lipid with biological activity. In: Ether Lipids: Biochemical and Biomedical Aspects. Mangold H K, Paltauf F. (eds). New York: Academic Press; 1983: 356-76.
- 12 Benveniste J, Nunez D, Duriez P, Korth R, Bidault J, Fruchart J C. Preformed PAF-acether and lyso PAF-acether are bound blood lipoproteins. FEBS Letters 1987; 226: 371-76.
- 13 Bhagyalakshmi A, Frangos J A. Mechanism of shear-induced prostacyclin production in endothelial cells. Biochem Biophys Res Commun 1989; 158: 31-7.
- 14 Blank M L, Cress E A, Wittle T, Snyder F. In vivo metabolism of a new class of biologically active phospholipids : 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet-activating hypotensive phospholipid. Life Sci 1981; 29: 769-75.
- 15 Blank M L, Lee T C, Fitzgerald V, Snyder F. A specific acetylhydrolase for l-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid). J Biol Chem 1981; 256: 175-8.
- 16 Böhme E, Jung R, Mechler I. Guanylate cyclase in human platelets. In: Methods in Enzymology. Vol. 38. Hardman J G, O’Malley B W. (eds). New York: Academic Press; 1974: 199-202.
- 17 Braquet P, Tourqui L, Shen T Y, Vargaftig B B. Perspectives in platelet-activating factor research. Pharmacol Rev 1987; 39: 97-145.
- 18 Brock T A, Gimbrone Jr M A. Platelet activating factor alters calcium homeostasis in cultured vascular endothelial cells. Am J Physiol 1986; 250: H1086-92.
- 19 Buchanan M R, Butt R W, Magas Z, Van Ryn J, Hirsh J, Nazir D J. Endothelial cells produce a lipoxygenase-derived chemorepellant which influences platelet/endothelial cell interactions : effect of aspirin and salicylate. Thromb Haemost 1985; 53: 306-11.
- 20 Buchanan M R, Haas T A, Lagarde M, Guichardant M. 13-Hydroxy-octadecadienoic acids is the vessel wall chemorepellant, LOX. J Biol Chem 1985; 260: 16056-9.
- 21 Busse R, Förstermann U, Matsuda H, Pohl U. The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. Pflügers Arch 1984; 401: 77-83.
- 22 Busse R, Tragisch G, Bassenge E. The role of endothelium in the control of vascular tone. Basic Res Cardiol 1985; 80: 475-90.
- 23 Busse R, Lückhoff A, Bassenge E. Endothelium-derived relaxant factor inhibits platelet activation. Naunyn-Schmiedebergs Arch Pharmacol 1987; 336: 566-71.
- 24 Busse R, Lückhoff A, Winter I, Mülsch A, Pohl U. Fendiline and calmidazolium enhance the release of endothelium-derived relaxant factor and of prostacyclin from cultured endothelial cells. NaunynSchmiedebergs Arch Pharmacol 1988; 337: 79-84.
- 25 Busse R, Mülsch A, Winter I, Bassenge E. Asymmetrical release of vasoactive autacoids from cultured endothelial cells. Pflügers Arch 1988; 411 (Suppll): R42.
- 26 Busse R, Ogilvie A, Pohl U. Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries. Am J Physiol 1988; 254: H828-32.
- 27 Busse R, Lückhoff A, Pohl U. Generation and transmission of endothelium-dependent signals. In: Vascular Endothelium: Receptors and Transduction Mechanisms. Catravas J D, Gillis C N, Ryan U S. (eds). New York London: Plenum Press; 1989. (in press).
- 28 Busse R, Lückhoff A, Pohl U, Bassenge E. EDRF-induced inhibition of platelet aggregation: synergy between PGI2 and EDRF. Funktionsanalyse Biologischer Systeme. 1989. 19 (in press).
- 29 Bussolino F, Breviario F, Tetta C, Aglietta M, Mantovani A, Dejana E. Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. J Clin Invest 1986; 77: 2027-33.
- 30 Bussolino F, Camussi G, Aglietta M, Braquet P, Bosia A, Pescarmona G, Sanavio F, D’Urso N, Marchisio P C. Human endothelial cells are target for plateletactivating factor. I. Platelet-activating factor induces changes in cytoskeleton structures. J Immunol 1987; 139: 2439-46.
- 31 Bussolino F, Camussi G, Baglioni C. Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin la. J Biol Chem 1988; 263: 11856-61.
- 32 Camussi G, Aglietta M, Coda R, Bussolino F, Piacibello W, Tetta C. Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils, and basophils. Immunology 1981; 42: 191.
- 33 Camussi G, Aglietta M, Malavas F, Tetta C, Piacibello W, Sanavio F, Bussolino F. The release of platelet-activating factor from human endothelial cells in culture. J Immunol 1983; 131: 2397-403.
- 34 Camiissi G, Bussolino F, Tetta C, Piacibello W, Aglietta M. Biosynthesis and release of platelet-activating factor from human monocytes. Int Arch Allergy Appl Immunol 1983; 70: 245-51.
- 35 Cherry P D, Furchgott R F, Zawadzki J V, Jothianandan D. The role of endothelial cells in the relaxation of isolated arteries by bradykinin. Proc Natl Acad Sci 1982; 79: 2106-10.
- 36 Chesbro J H, Fuster V, Elveback L R, Clements I P, Smith H C, Holmes Jr D R, Bardsley W T, Pluth J R, Wallace R B, Puga F J, Orszulak T A, Piehler J M, Danielson G K, Schaff H V, Frye R L. Effect of dipyramidole and aspirin on late vein-graft patency after coronary bypass operation. N Engl J Med 1984; 310: 209-14.
- 37 Chignard M, Le Couedic J P, Vargaftig B B, Benveniste J. Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents. Br J Haematol 1980; 46: 455-64.
- 38 Chilton F H, O’Flaherty J T, Ellis J M, Swendsen C L, Wykle R L. Selective acylation of lyso platelet-activating factor by arachidonate in human neutrophils. J Biol Chem 1983; 258: 7268-71.
- 39 Cocks T M, Angus J A. Endotheliumdependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 1983; 305: 627-30.
- 40 Curwen K D, Gimbrone Jr M A, Handin R I. In vitro studies of thromboresistance. The role of prostacyclin (PGI2) in platelet adhesion to cultured normal and virally transformed human vascular endothelial cells. Lab Invest 1980; 42: 366-74.
- 41 Czervionke R L, Hoak J C, Fry G L. Effect of aspirin on thrombin-induced adherence of platelets to cultured cells from the blood vessel wall. J Clin Invest 1978; 62: 847-56.
- 42 De Caterina R, Gianessi D, Bernini W, Mazzone A. Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatet effects of organic nitrates. Thromb Haemost 1988; 59: 207-11.
- 43 DeMey J G, Vanhoutte P M. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol 1981; 316: 347-55.
- 44 DeMey J G, Claeys M, Vanhoutte P M. Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery. J Pharmacol Exp Ther 1982; 222: 166-73.
- 45 Derian C K, Moskowitz M A. Polyphosphoinositide hydrolysis in endothelial cells and carotid artery segments (Bradykinin-2 receptor stimulation is calcium-independent). J Biol Chem 1986; 261: 3831-7.
- 45a Douglas W W. Autacoids: Introduction. In: The Pharmacological Basis of Therapeutics. Gilman AGoodman, Goodman L S, Rail T W, Murad F. (eds). New York: Macmillan; 1985: 604-59.
- 46 Feelisch M, Noak E. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 1987; 139: 19-30.
- 47 Förstermann U, Trogisch G, Busse R. Species-dependent differences in the nature of endothelium-derived vascular relaxing factor. Eur J Pharmacol 1984; 106: 639-43.
- 48 Förstermann U, Neufang B. Endotheliumdependent vasodilation by melittin: are lipoxygenase products involved?. Am J Physiol 1985; 249: H14-9.
- 49 Förstermann U, Goppelt-Strübe M, Frölich J C, Busse R. Inhibitors of acyl-coenzyme A: lysolecithin acyltranferase activate the production of endothelium-derived vascular relaxing factor. J Pharmacol Exp Ther 1986; 238: 352-9.
- 50 Förstermann U, Mülsch A, Böhme E, Busse R. Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circ Res 1986; 58: 531-8.
- 51 Förstermann U, Mügge A, Alheid U, Haverich A, Frölich J C. Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries. Circ Res 1988; 62: 185-90.
- 52 Furchgott R F, Zawadzki J V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
- 53 Furchgott R F. Role of endothelium in responses of vascular smooth muscle. Circ Res 1983; 53: 557-73.
- 54 Furchgott R F. Studies on relaxation of rabbit aorta by sodium nitrite : the basis for the proposal that the acid-activatable inhibitory factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In: Mechanisms of Vasodilatation. Vol. 4. Vanhoutte P M. (ed). New York: Raven Press; 1988: 401-14.
- 55 Furlong B, Henderson A H, Lewis M J, Smith J A. Endothelium-derived relaxant factor inhibits in vitro platelet aggregation. Br J Pharmacol 1987; 90: 687-92.
- 56 Garthwaite J, Charles S L, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 1988; 336: 385-8.
- 57 Gillis C N, Pitt B R. The fate of circulating amines within the pulmonary circulation. Ann Rev Physiol 1982; 44: 269-81.
- 58 Griffith T M, Edwards D H, Lewis M J, Newby A C, Henderson A H. The nature of endothelium-derived vascular relaxant factor. Nature 1984; 308: 645-7.
- 59 Griffith T M, Hughes DEdwards, Lewis M J, Henderson A H. Ergometrine-induced arterial dilatation: an endothelium-mediated effect. J Mol Cell Cardiol 1984; 16: 479-82.
- 60 Griffith T M. Studies of endotheliumderived relaxant factor (EDRF), its nature and mode of action. Eur Heart J 1985; 06: 37-49.
- 61 Griffith T M, Edwards D H, Davies R L I, Harrison T J, Evans K T. EDRF coordinates the behaviour of vascular resistance vessels. Nature 1987; 329: 442-5.
- 62 Grondin C M, Campeau L, Lespérance J, Enjalbert M, Bourassa M G. Comparison of late changes in internal mammary artery and saphenous vein grafts in two consecutive series of patients 10 years after operation. Circulation 1984; 70 (Suppl I): 1208-12.
- 63 Gryglewski R J, Botting R M, Vane J R. Mediators produced by the endothelial cell. Hypertension 1988; 12: 530-48.
- 64 Harlan J M, Killen P D, Harker L A, Striker G E. Neutrophil-mediated endothelial injury in vitro. J Clin Invest 1981; 68: 1394-403.
- 65 Hayashi H, Kudo I, Inoue K, Nomura H, Nojima S. Macrophage activation by PAF incorporated into dipalmitoyl-phosphatidylcholine-cholesterol liposomes. J biochem 1985; 97: 1255-8.
- 66 Henson P M, Johnston R B. Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins. J Clin Invest 1987; 79: 669-74.
- 67 Hogan J C, Lewis M J, Henderson A H. In vivo EDRF activity influences platelet function. Br J Pharmacol 1988; 94: 1020-2.
- 68 Hwang S B, Lee C S C, Cheah M J, Shen T Y. Specific receptor sites for l-O-alkyl-2O-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) on rabbit platelet and guinea pig smooth muscle membranes. Biochemistry 1983; 22: 4756-63.
- 69 Hwang S B, Lam M H, Shen T Y. Specific binding sites for platelet-activating in human lung tissue. Biochem Biophys Res Commun 1985; 128: 972-9.
- 70 Hwang S B. Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. J Biol Chem 1988; 263: 3225-33.
- 71 Ignarro L J, Byrns R E, Wood K S. Biochemical and pharmacological properties of endothelium-derived relaxing factor and its similarity to nitric oxide radical. In: Mechanisms of Vasodilatation. Vol,4. Vanhoutte P M. (ed). New York: Raven Press; 1988: 427-35.
- 72 Ignarro L J. Endothelium-derived nitric oxide: actions and properties. FASEB J 1989; 03: 31-6.
- 73 Iyengar R, Stuehr D J, Mariette M A. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines : precursors and role of the respiratory burst. Proc Natl Acad Sci USA 1987; 84: 6369-73.
- 74 Kasuya Y, Masuda Y, Shigenobu K. Possible role of endothelium in the vasodilator response of rat thoracic aorta to platelet activating factor (PAF). J Pharmacobiodyn 1984; 07: 138-42.
- 75 Katusic Z S, Shepherd J T, Vanhoutte P M. Vasopressin causes endothelium-dependent relaxations of the canine basilar artery. Circ Res 1984; 55: 575-9.
- 76 Katusic Z S, Shepherd J T, Vanhoutte P M. Oxytocin causes endothelium-dependent relaxations of canine basilar arteries by activating Vl-vasopressinergic receptors. J Pharmacol Exp Ther 1986; 236: 166-70.
- 77 Korth R, Hirafuji M, Benveniste J. Comparison of human endothelial cells in culture and platelets for [3H]paf-acether binding. Fed Proc 1987; 46: 444 (Abstr).
- 78 Kramer R M, Patton G M, Pritzker C R, Deykin D. Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of l-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. J Biol Chem 1984; 259: 13316-20.
- 79 Lartique-Mattei C, Godeneche D, Chabard J L, Petit J, Berger J A. Pharmacokinetic study of 3H-labelled PAF-acether. II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. Agents Actions 1984; 15: 643-8.
- 80 Lee T C, Malone B, Wasserman S I, Fitzgerald V, Snyder F. Activities of enzymes that metabolize platelet-activating factor (l-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of calcium ionophore. Biochem Biophys Res Commun 1982; 105: 1303-8.
- 81 Levin R I, Weksler B B, Jaffe E A. The interaction of sodium nitroprusside with human endothelial cells and platelets: nitroprusside and prostacyclin synergistically inhibit platelet function. Circulation 1982; 66: 1299-307.
- 82 Lewis M S, Whatley R E, Cain P, McIntyre T M, Prescott S M, Zimmerman G A. Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induced endothelium cell-dependent neutrophil adhesion. J Clin Invest 1988; 82: 2045-55.
- 83 Long C J, Stone T W. The release of endothelium-derived relaxant factor is calcium dependent. Blood Vessels 1985; 22: 205-8.
- 84 Loop F D, Lytle B W, Cosgrove D M, Stewart R W, Goormastic M, Williams G W, Golding L A R, Gill C C, Taylor P C, Sheldon W C, Proudfit W L. Influence of the internal mammary artery graft on 10-year survival and other cardiac events. N Engl J Med 1986; 314: 1-6.
- 85 Lucchesi B R, Mickelson J K, Homeister J W, Jackson C V. Interaction of the formed elements of blood with the coronary vasculature in vivo. Fed Proc 1987; 46: 63-72.
- 86 Ludmer P L, Selwyn A P, Shook T L, Wayne R R, Mudge G H, Alexander R W, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046-51.
- 87 Lückhoff A, Busse R. Increased free calcium in endothelial cells under stimulation with adenine nucleotides. J Cell Physiol 1986; 126: 414-20.
- 88 Lückhoff A, Pohl U, Busse R. Increased free calcium in endothelial cells in response to hypoxia and restitution of normoxia. Pflügers Arch 1986; 406 (Suppll): R46.
- 89 Lückhoff A, Busse R, Winter I, Bassenge E. Characterization of vascular relaxant factor released from cultured endothelial cells. Hypertension 1987; 09: 295-303.
- 90 Lückhoff A, Pohl U, Mülsch A, Busse R. Differential role of extraand intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells. Br J Pharmacol 1988; 95: 189-96.
- 91 Lüscher T F, Cooke J P, Houston D S, Neves R J, Vanhoutte P M. Endotheliumdependent relaxations in human arteries. Mayo Clin Proc 1987; 62: 601-6.
- 92 Lüscher T F, Diederich D, Siebenmann R, Lehmann K, Stulz P, von Segesser L, Yang Z, Turina M, Grädel E, Weber E, Bühler F R. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med 1988; 319: 462-7.
- 93 Lynch J M, Henson P M. The intracellular retention of newly synthesized plateletactivating factor. J Immunol 1986; 137: 2653-61.
- 94 Macdonald P S, Read M A, Dusting G J. Synergistic inhibition of platelet aggregation by endothelium-derived relaxing factor and prostacyclin. Thromb Res 1988; 49: 437-49.
- 95 Marietta M A, Yoon P S, Iyengar R, Leaf C D, Wishnok J S. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry 1988; 27: 8706-11.
- 96 McIntyre T M, Zimmerman G A, Satoh K, Prescott S M. Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. J Clin Invest 1985; 76: 271-80.
- 97 McIntyre T M, Zimmerman G A, Prescott S M. Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. Proc Natl Acad Sci USA 1986; 83: 2204-8.
- 98 Melkumyants A M, Balashov S A, Veselova E S, Khayutin V M. Continuous control of the lumen of feline conduit arteries by blood flow rate. Cardiovasc Res 1987; 21: 863-70.
- 99 Mencia-Huerta J M, Lewis R A, Razin E, Austen K F. Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE. Immunology 1983; 131: 2958-64.
- 100 Moncada S, Palmer R M J, Gryglewski R J. Mechanism of action of some inhibitors of endothelium-derived relaxing factor. Proc Natl Acad Sci USA 1986; 83: 9164-8.
- 101 Mülsch A, Böhme E, Busse R. Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells. Eur J Pharmacol 1987; 135: 247-50.
- 102 Mülsch A, Lückhoff A, Pohl U, Busse R, Bassenge E. LY 83583 (6-anilino-5,8-qui-nolinedione) antagonizes cyclic GMP-de-pendent inhibition of platelet activation. Naunyn-Schmiedebergs Arch Pharmacol 1989; 338 (in press).
- 103 Naccache P H, Molski M M, Volpi M. et al. Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. J Leukocyte Biol 1986; 40: 533-48.
- 104 Nathan C F. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest 1987; 80: 1550-60.
- 105 O’Flaherty J T, Nishihira J. Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils. J Immunol 1987; 138: 1889-95.
- 106 Okies J E, Page U S, Bigelow J C, Krause A H, Salomon N W. The left internal mammary artery: the graft of choice. Circulation 1984; 70 (Suppll): 1213-21.
- 107 Olesen S P, Clapham D E, Davies P F. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature 1988; 331: 168-70.
- 108 Palmer R M J, Ferrige A G, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-6.
- 109 Palmer R M J, Ashton D S, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664-6.
- 110 Palmer R M J, Moncada S. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun 1989; 158: 348-52.
- 111 Pearson J D, Gordon J L. Nucleotide metabolism by endothelium. Ann Rev Physiol 1985; 47: 617-27.
- 112 Pirotton S, Raspe E, Demolle D, Erneux C, Boeynaems J M. Involvement of inositol 1,4,5-trisphosphate and calcium in the action of adenosine nucleotides on aortic endothelial cells. J Biol Chem 1987; 262: 17461-6.
- 113 Pohl U, Busse R, Kuon E, Bassenge E. Pulsatile perfusion stimulates the release of endothelial autacoids. J Appl Cardiol 1986; 01: 215-35.
- 114 Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986; 08: 37-44.
- 115 Pohl U, Dézsi L, Simon B, Busse R. Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo. Am J Physiol 1987; 253: H234-9.
- 116 (Literaturstelle entfällt).
- 117 Pohl U, Busse R. Hypoxia stimulates the release of endothelium-derived relaxant factor (EDRF). Am J Physiol 1988; 254: 1595-1600.
- 118 Pohl U, Busse R. Reduced nutritional blood flow in autoperfused rabbit hindlimbs following inhibition of endothelial vasomotor function. In: Resistance Arteries. Halpern W, Pegram B, Bray den J, Mackey K, McLaughlin M, Osol G. (eds). Ithaca NY: Perinatology Press; 1988: 10-16.
- 119 Pohl U, Busse R. EDRF increases cGMP in platelets during passage through the coronary vascular bed. Circ Res. 1989 (in press).
- 120 Prescott S M, Zimmerman G A, McIntyre T M. Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. Med Sci 1984; 81: 3534-8.
- 121 Radomski M W, Palmer R M J, Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987; 92: 639-46.
- 122 Radomski M W, Palmer R M J, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987; 148: 1482-9.
- 123 Rapoport R M, Murad F. Endotheliumdependent and nitrovasodilator-induced relaxation of vascular smooth muscle : role of cyclic GMP. J Cyclic Nucleotide Res 1983; 09: 281-96.
- 124 Rapoport R M. Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circ Res 1986; 58: 407-10.
- 125 Rees D D, Palmer R M J, Moncada S. Effect of SKF 525A on the release of nitric oxide and prostacyclin from endothelial cells. Eur J Pharmacol 1988; 150: 149-54.
- 126 Rubanyi G M, Lorenz R R, Vanhoutte P M. Bioassay of endothelium-derived relaxing factor(s) : inactivation by catecholamines. Am J Physiol 1985; 249: H95-101.
- 127 Rubanyi G M, Romero J C, Vanhoutte P M. Flow-induced release of endotheliumderived relaxing factor. Am J Physiol 1986; 250: H1145-9.
- 128 Ryan U S, Ryan J W, Whitaker C, Chiu A. Localization of angiotensin-converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence. Tiss Cell 1976; 08: 125-45.
- 129 Sacks T, Moldow C F, Craddock P R, Bowers T K, Jacob H S. Oxygen radicals mediate endothelial cell damage by complementrstimulated granulocytes. An in vitro model immune vascular damage. J Clin Invest 1978; 61: 1161-7.
- 130 Schächter M, Thom S, Hughes A, Martin G, Goldberg P, Sever P. Calcitonin generelated peptide: vasodilator responses in the human vasculature. In: Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium. Vanhoutte P M. (ed). New York: Raven Press; 1988: 475-8.
- 131 Schmidt H H H W, Nau H, Wittfoht W, Gerlach J, Prescher K E, Klein M M, Niroomand F, Böhme E. Arginine is a physiological precursor of endotheliumderived nitric oxide. Eur J Pharmacol 1988; 154: 213-6.
- 132 Schrör H, Schrör K. Organische Nitrate und Thrombozytenfunktion. Hämostaseologie 1988; 08: 90-9.
- 133 Schrör K. Prostaglandine and verwandte Verbindungen: Bildung, Funktion und pharmakologische Beeinflussung. Stuttgart New York: Thieme; 1984
- 134 Seidel C L, La Rochelle J. Venous and arterial endothelia: different dilator abilities in dog vessels. Cire Res 1987; 60: 626-30.
- 135 Shigenobu K, Masuda Y, Tanaka Y, Kasuya Y. Platelet-activating factor analogues: lack of correlation between their activities to produce hypotension and endotheliummediated vasodilation. J PharmacobioDyn 1985; 08: 128-33.
- 136 Sibley D R, Benovic J L, Caron M G, Lefkowitz R J. Regulation of transmembrane signaling by receptor phosphorylation. Cell 1987; 48: 913-22.
- 137 Singer H A, Peach M J. Calciumand endothelial-mediated vascular smooth muscle relaxation in rabbit aorta. Hypertension 1982; 04 (SupplII): 1119-25.
- 138 Sinoway L I, Hendrickson C, Davidson Jr W R, Prophet S, Zelis R. Characteristics of flow-mediated brachial artery vasodilation in human subjects. Circ Res 1989; 64: 32-42.
- 139 Smedly L A, Tonnesen M G, Sandhaus R A, Haslett C, Guthrie L A, Johnston Jr R B, Henson P M, Worthen G S. Neurophilmediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest 1986; 77: 1233-43.
- 140 Smiesko V, Kozik J, Dolezel S. Role of endothelium in the control of arterial diameter by blood flow. Blood Vessels 1985; 22: 247-51.
- 141 Sneddon J M, Vane J R. Endotheliumderived relaxing factor reduces platelet adhesion to bovine endothelial cells. Proc Natl Acad Sci USA 1988; 85: 2800-4.
- 142 Spencer F C. The internal mammary artery: the ideal coronary bypass graft?. N Engl J Med 1986; 314: 50-1.
- 143 Spokas E G, Folco G C, Quilley J, Chander P, McGiff J C. Endothelial mechanism in the vascular action of hydralazine. Hypertension 1983; 05: 1107-11.
- 144 Stafforini D M, McIntyre T M, Carter M E, Prescott S M. Human plasma plateletactivating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. J Biol Chem 1987; 262: 4215-22.
- 145 Thom S A, Hughes A D, Martin G N, Sever P S. The release of the endotheliumderived relaxing factor from isolated human arteries. J Hypertension 1985; 03 (Suppl 3): S97-99.
- 146 Toda N. Endothelium-dependent relaxation induced by angiotensin II and histamine in isolated arteries of the dog. Br J Pharmacol 1984; 81: 301-7.
- 147 Touqui L, Jacquemin C, Dumarey C, Vargaftig B B. l-0-Alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. Biochim Biophys Acta 1985; 833: 111-8.
- 148 Turitto V T, Baumgartner H R. Platelet interaction with subendothelium in a perfusion system. Physical role of red blood cells. Microvasc Res 1975; 09: 335-44.
- 149 Twort C H C, van Bremen C. Cyclic guanosine monophosphate-enhanced sequestration of Ca2+ by sarcoplasmic reticulum in vascular smooth muscle. Circ Res 1988; 62: 961-4.
- 150 Valone F H, Coles E, Reinhold V R, Goetzl E J. Specific binding of phospholipid platelet-activating factor by human platelets. J Immunol 1982; 129: 1637-41.
- 151 Valone F H, Goetzl E J. Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine. Immunology 1983; 48: 141-9.
- 152 Valone F H. Identification of plateletactivating factor receptors in P388D1 murine macrophages. J Immunol 1988; 140: 2389-94.
- 153 VanDeVoorde J, Leusen I. Role of the endothelium in the vasodilator response of rat thoracic aorta to histamine. Eur J Pharmacol 1983; 87: 113-20.
- 154 Varani J, Fligiel S E G, Till G O, Kunkel R G, Ryan U S, Ward P A. Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical. Lab Invest 1985; 53: 656-63.
- 155 Vercellotti G M, Yin H Q, Gustafson K S, Nelson R D, Jacob H S. Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage. Blood 1988; 71: 1100-7.
- 156 Voelkel N F, Worthen S, Reeves J T, Henson P M, Murphy R C. Nonimmunological production of leukotrienes induced by platelet-activating factor. Science 1982; 218: 286-8.
- 157 Weiss H J, Turitto V T. Prostacyclin (prostaglandin I2) inhibits platelet adhesion and thrombus formation in subendothelium. Blood 1979; 53: 244-60.
- 158 Weiss S J, Young J, LoBuglio A F, Slivka A, Nimeh N F. Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest 1981; 68: 714-21.
- 159 Weiss S J, Regiani S. Neutrophils degrade subendothelial matrices in the presence of alpha-l-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites. J Clin Invest 1984; 73: 1297-303.
- 160 Whatley R E, Zimmerman G A, McIntyre T M, Taylor R, Prescott S M. Production of platelet-activating factor by endothelial cells. Semin Thromb Hemost 1987; 13: 445-53.
- 161 Wright C D, Mülsch A, Busse R, Oßwald H. Generation of nitric oxide by human neutrophils. Biochem Biophys Res Commun 1989; 160: 813-19.
- 162 Zimmerman G A, McIntyre T M, Prescott S M. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J Clin Invest 1985; 76: 2235-46.