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J Neurol Surg B Skull Base 2019; 80(03): 258-263
DOI: 10.1055/s-0038-1669420
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Prognostic Factors in Paranasal Sinus Squamous Cell Carcinoma and Adenocarcinoma: A SEER Database Analysis

Sumit Jain
1   Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, United States
,
Yan Li
2   Department of Otolaryngology, Rush University, Chicago, Illinois, United States
,
Edward C. Kuan
3   Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States
,
Bobby A. Tajudeen
4   Department of Otorhinolaryngology – Head and Neck Surgery, Center for Skull Base and Pituitary Surgery, Rush University Medical Center, Chicago, Illinois, United States
,
Pete S. Batra
4   Department of Otorhinolaryngology – Head and Neck Surgery, Center for Skull Base and Pituitary Surgery, Rush University Medical Center, Chicago, Illinois, United States
› Author Affiliations
Further Information

Publication History

10 December 2017

07 July 2018

Publication Date:
24 August 2018 (online)

Also available atMedOne
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Abstract

Background Outcome studies on sinonasal malignancy are limited to retrospective case series, often with inclusion of diverse histology and short follow-up. The objective of this study was to identify key predictive variables that independently impact survival for paranasal sinus squamous cell carcinoma (SCC) and adenocarcinoma (AC) and to compare these variables in the context of these two distinct clinicopathologic entities.

Methods: Analysis was conducted using the Surveillance, Epidemiology, and End Results database from 1973 to 2012 to identify key variables that impact survival for SCC and AC.

Results A total of 3,714 cases were included. There were 2,895 SCC cases and 819 AC cases. The mean age at diagnosis was 64.1 years. The male to female ratio for SCC and AC was 1.85 and 1.04, respectively. Patients with SCC and AC were most often diagnosed with stage IV disease in 61.8 and 63.4% of cases, respectively. The majority of patients received combined surgery and radiation (52% for SCC and 43.1% for AC). For SCC, increased age (p < 0.001) and stage (p < 0.001) were negative predictors, and surgery improved survival (p < 0.001) on multivariate analysis. For AC, prognostic factors associated with worse survival include increased age (p < 0.001) and grade (p < 0.001) on multivariate analysis. Overall survival was significantly higher in AC compared with SCC at 5 years (p = 0.001).

Conclusion SCC and AC of the paranasal sinuses are both aggressive malignancies with poor survival. For both histological subtypes, increased age predicts worse survival and grade also closely links to survival in AC. These data have important potential implications for treatment planning and pretreatment counseling.

Keywords

sinonasal - carcinoma - squamous cell carcinoma - adenocarcinoma - outcomes - prognostic factors

Note

This study was presented as a poster presentation at the ARS 61st Annual Meeting, September 25–26, 2015, in Dallas, Texas, United States.