Keywords
tracheoesophageal fistula - transverse cervical artery flap - repair
Acquired tracheoesophageal fistulas (TEF) are rare (≤1% of patients) but are associated
with significant morbidity and high mortality if untreated.[1]
[2] The majority of cases are due to prolonged or complicated endotracheal intubation
(EI), tracheostomy, or esophageal malignancy, or subsequent to radiation or chemotherapy
for treatment of the latter. Other etiologies include esophageal stenting and complications
secondary to endoscopic procedures.[2]
[3]
[4]
[5]
[6] The pathophysiology is thought to involve chronic inflammation of the esophagus
or posterior wall of the trachea, ultimately promoting a fistula between these two
structures.[1]
[6]
[7]
[8] According to literature, risk factors primarily depend on the etiology; however,
excessive balloon pressures, defined by greater than 20 mm Hg, and prolonged intubation,
defined as longer than 2 weeks, are among the strongest predictors of acquired TEF.[1]
[7] In two reported cases, persistent air leaks (i.e., requiring reinflation or increased
balloon volume) resulted in TEF.[7]
Patients commonly present with refractory pneumonia, aspiration, hypoxemia, acute
respiratory distress, enteral feed in endotracheal aspirate, or gastric distention
following extubation.[2] In some cases, it can be difficult to distinguish normal functional deterioration
from deterioration that is secondary to intubation; for example, up to 51% of patients
intubated for at least 48 hours may experience dysphagia following extubation.[9] The diagnostic algorithm includes an esophagogram, followed by imaging with a CT
scan, and, more recently, a CT scan with three-dimensional reconstructions, a bronchoscopy,
and an esophagoscopy.[10]
Spontaneous closure rarely occurs, and the primary treatment modalities include interventional
therapy with stenting via bronchoscopy, esophagoscopy, or surgical correction, which
is the most definitive. However, surgical intervention is associated with higher risks
due to the involvement of vital anatomy and, often, technical challenges requiring
multispecialty care for surgical access and repair. Mortality rates of 5.7% and complications
rates of > 50% following surgical intervention have been reported.[9]
[11] In addition, adjunct supportive management is commonly utilized; this type of management
may entail enteral and parenteral alimentation modalities, including gastric tubes,
antibiotics, elimination of airway secretions, and intravenous hyperalimentation.[2]
Case Description
A 69-year-old male patient presented with a past medical history of chronic obstructive
pulmonary disease. He presented to our hospital after initially suffering from cardiac
arrest while on a cruise ship. Advanced cardiac life support was initiated, and he
received three rounds of cardiopulmonary resuscitation, two shocks from the automated
external defibrillator, and two boluses of epinephrine before return of spontaneous
circulation. He underwent several attempts for endotracheal intubation in the field,
which were eventually successful in securing an airway. He was brought to University
Medical Center New Orleans where he was found to have suffered from a myocardial infarction
with subsequent ventricular fibrillation. He was admitted to the hospital for critical
care management and coronary stenting.
The patient showed improvement; however, after failing a spontaneous breathing trial,
he was reintubated with intermittent positive pressure ventilation. His sputum cultures
were also positive for Haemophilus parainfluenzae for which he was started on a course of cefotaxime. Over the course of his stay,
his endotracheal tube was replaced due to malfunction, his secretions worsened, and
the patient eventually became septic requiring the use of norepinephrine and vasopressin.
Subsequent bronchial alveolar lavage cultures also grew gram-positive cocci; he was
then started on vancomycin. Eventually, his condition stabilized. Despite decreased
secretions and broad-spectrum antibiotic treatment, his respiratory status remained
compromised due to generalized weakness, high-pressure support requirements, and delirium/agitation.
His condition gradually improved and on hospital day 11, he was extubated to nasal
intermittent positive pressure ventilation. The patient initially tolerated the transition;
however, he rapidly decompensated the next morning and required emergent intubation
due to hypoxemia. On further exam, copious residual tube feed was found in his upper
airway and oropharynx, causing obstruction. Bronchial alveolar lavage and tracheostomy
were planned for true ventilator weaning. He was also restarted on vancomycin and
cefepime given his aspiration of gastric contents. During this time, he suffered from
another episode of cardiac arrest in the setting of hypoxemia likely secondary to
airway obstruction. He recovered from this episode with no noticeable deficits or
sequelae. He remained on mechanical ventilation and developed endotracheal tube leakage,
which required multiple exchanges; tracheomalacia and stenosis were suspected on CT
imaging. He was monitored for repeated leaks despite doing well on volume support
ventilation and having minimal oxygen support needs.
A tracheostomy was performed on day 15 of the hospital course due to repeated failure
of extubation. Following the procedure, the patient was unable to maintain positive
pressure ventilation and tracheal occlusion with maximal cuff inflation. He also developed
active aspiration at which point the tracheostomy tube was removed and exchanged for
a standard endotracheal tube to protect his airway. Upon further inspection with bronchoscopy,
the surgical team discovered a tracheal defect, which was confirmed to be a TEF at
the level of C7/T1 on CT scan. The timing of fistulization was uncertain, but this
discovery provided compelling evidence for the recurrent aspiration events and significant
difficulty in airway management. Definitive surgical correction of the fistula was
planned with a multimodal approach between otolaryngology, cardiothoracic surgery,
and plastic and reconstructive surgery teams. Because of the patient's hemodynamic
status and the difficult location of his fistula, repair was ultimately deferred until
his overall condition and nutritional status was optimized. Percutaneous endoscopic
gastrostomy and tracheostomy revision were performed on day 25 of his hospital course.
After medical and nutritional optimization, plans were made for surgical repair of
the TEF with a transverse cervical flap coverage on day 40 of hospitalization.
Postoperative Course
The repair went smoothly with no complications, and the patient was immediately transferred
back to the intensive care unit. He was extubated on postoperative day (POD) 1 following
a successful breathing trial; however, he was reintubated on POD 3 due to hypercapnic
respiratory failure secondary to his limited capacity to clear secretions and global
respiratory weakness. Otherwise, the repair remained viable with no complications
which was confirmed under bronchoscopic exam. A tracheotomy was performed on POD 14.
The procedure was tolerated well with no identifiable issues and minimal vent settings.
The patient progressed favorably and was evaluated with a follow-up esophagram, swallow
study, and bronchoscopy which showed the repair had maintained its integrity with
no leaks. His clinical course improved until the patient was medically stable and
discharged to a long-term, acute care hospital for rehabilitation, and is currently
doing well.
Discussion
Because spontaneous closure rarely occurs, surgical intervention is typically required
for effective and definitive repair of a TEF. Interventional techniques and adjunct
supportive therapy may serve as temporizing measures to stabilize patients and optimize
them for surgical repair to address potential leaks.[12] Interventional techniques include esophageal stenting, airway stenting, or a combination
of both.[2] In addition, endoscopic closure using a variety of other methods has been reported,
but with limited success, cardiac septal defect occluders, silicon rings, or vascular
plugs have been reported to close the fistula.[13]
[14] Like interventional management, a plethora of approaches have been used to surgically
correct acquired TEF; however, repair remains difficult, with complication rates reported
up to 55% in large retrospective studies.[9]
[11] The most common approaches include initial cervical approach or cervical approach
combined with a sternotomy for access, followed by tracheoesophageal repair.
Meticulous surgical repair of both tracheal and esophageal defects is essential due
to the complexity of operating on an airway while maintaining ventilation and the
propensity for complications, which themselves are related to the physiology of both
the airway and the muscular tract of the esophagus. Normal functions, such as air
movement and peristalsis, make healing a mechanical and dynamic process that can jeopardize
the integrity of repair. Ventilation can be managed in different ways, including manual
oxygen jet ventilation, high-frequency jet ventilation, distal tracheal intubation,
spontaneous ventilation, and cardiopulmonary bypass.[15] Final repair decisions are ultimately determined by the etiology of TEF; thus, the
following techniques and usages are specific to benign postintubation fistulization.
Tracheal repair management poses a complex undertaking, and defects are typically
managed with concomitant tracheal resection and reconstruction (TRR) with end-to-end
anastomosis. Depending on the level of involvement, resection and reconstruction may
also involve laryngeal anatomy (LTRR). Furthermore, larger defects may be repaired
using TRR or LTRR over a tracheal T-tube.[11]
[15]
[16]
[17]
[18]
[19] To ease resection and anastomosis, tracheal mobilization and release procedures
may be utilized to allow for larger resection and less tension on the anastomosis,
which is the primary cause of post-repair complications and morbidity. Thus, the anatomic
level of fistulization necessitates special consideration in regard to the surgical
approach.[15]
[18]
[20]
Esophageal repair typically consists of two-layer closure, one-layer closure, esophagostomy,
or end-to-end esophageal anastomosis. Of note, esophagostomy is typically adjunct
therapy, and end-to-end anastomosis is usually reserved as a last resort for repair.
Two-layer closure is the most significant and widely used technique due to both the
structural integrity and long-term viability of repair. This is due to higher bursting
wall tension and superior healing compared with other techniques; however, closure
involves specific directional placement of sutures in the mucosal layer followed by
the muscular layer of the esophagus. The directionality of the sutures ensures balance
of the forces generated by physiologic muscular contractions and helps prevent dehiscence
of the repair.[12]
[16]
[19]
[20]
[21] The esophageal and tracheal repairs are then buttressed together using alloderm,
intercostal muscle flaps, omental flaps, or other free flaps.[12]
[17]
[18]
[22] Our case offers a novel surgical approach using a pedicled TCA flap to buttress
the tracheal and esophageal closures in the repair of a nonmalignant acquired TEF.
Tessler et al describe the TCA flap as being a reliable pedicle with a reproducible
and easy dissection.[23] Due to the location of the TEF and the robust pedicle of TCA, the TCA pedicled flap
was deliberately chosen to reinforce the esophageal and tracheal repair. Currently,
there are no reported cases using this technique, yet this may offer a stronger surgical
option given the high complication rates with currently used flaps. Use of the TCA
flap may also offer further advantages such as low donor site morbidity, ease of harvest,
and minimal resulting functional or aesthetic deficit.[23] In addition, it is advantageous to interventional stenting techniques as it definitely
closes the TEF.
In conclusion, definitive surgical repair of acquired TEF has a high reported complication
rate. Although the TCA flap is described in the literature for use in head and neck
oncologic reconstruction, we propose the TCA flap as a viable technical option to
reinforce the surgical esophageal and tracheal repair. It is a reliable flap with
a robust and lengthy pedicle that is in close proximity to the defect and has low
donor site morbidity.
