Endoscopy 2019; 51(04): S70
DOI: 10.1055/s-0039-1681376
ESGE Days 2019 oral presentations
Friday, April 5, 2019 17:00 – 18:30: Colon cleansing 1 Club D
Georg Thieme Verlag KG Stuttgart · New York

EFFECTIVENESS AND TOLERABILITY OF VERY LOW VOLUME PREPARATION FOR COLONOSCOPY: A PROSPECTIVE, MULTICENTER STUDY

M Maida
1   Gastroenterology Unit, S. Elia – Raimondi Hospital, Caltanissetta, Italy
,
G Morreale
1   Gastroenterology Unit, S. Elia – Raimondi Hospital, Caltanissetta, Italy
,
E Sinagra
2   Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele Giglio, Cefalù, Italy
,
M Manganaro
1   Gastroenterology Unit, S. Elia – Raimondi Hospital, Caltanissetta, Italy
,
D Schillaci
3   Gastroenterology Unit, Ospedale Basarocco, Niscemi, Italy
,
A Cirrone Cipolla
3   Gastroenterology Unit, Ospedale Basarocco, Niscemi, Italy
,
S Garufi
1   Gastroenterology Unit, S. Elia – Raimondi Hospital, Caltanissetta, Italy
,
S Camilleri
1   Gastroenterology Unit, S. Elia – Raimondi Hospital, Caltanissetta, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

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    Aims:

    Effectiveness and tolerability of bowel cleansing is essential for a quality colonoscopy. The aims of this study were to assess the effectiveness and tolerability of novel 1L PEG preparation compared to 4L and 2L PEG solutions and to evaluate factors associated with a bowel cleansing success.

    Methods:

    605 consecutive outpatients undergoing colonoscopy after an afternoon-only or afternoon-morning PEG-based bowel cleansing were prospectively enrolled at 4 Sicilian hospitals from July to October 2018. Bowel cleansing was assessed through the Boston-Bowel-Preparation-Scale (BBPS) and cleansing success was defined as a total BBPS≥6 with a partial BBPS≥2 in each colon segment. Tolerability was evaluated through a semi-quantitative scale with a score ranging from 0 to 10.

    Results:

    Overall, 229 patients performed a 4L-PEG preparation (Selgesse), 261 a 2L-PEG cleansing (Moviprep or Clensia) and 115 a 1L-PEG preparation (Plenvu). The 1L preparation was the most tolerated with an average rating score of 7.5 ± 1.9, 7.2 ± 2.0 and 7.8 ± 1.3 (p < 0,04) respectively for 4L, 2L and 1L-PEG solution in the absence of serious adverse events within any of the three groups. Overall, bowel cleansing by BBPS was 6.1 ± 1.6, 6.0 ± 1.6 and 6.7 ± 1.5 (p = 0,007). A successful preparation was achieved in 72% of patients. At multivariate analysis low-fiber diet for at least 3 days preceding colonoscopy (OR = 2.34, 95% CI = 1.29 – 4.22; P = 0.005), colonoscopy within 5 hours after the end of the preparation (OR = 2.20, 95% CI = 1.1 – 4.85; P < 0.04), absence of diabetes (OR = 1.68, 95% CI = 1.02 – 2.85; P = 0.05), and tolerability rating (OR = 1.19, 95% CI = 1.08 – 1.32; P = 0.001) were independently associated with a bowel cleansing success.

    Conclusions:

    The novel 1L PEG preparation presents a higher effectiveness compared to higher volume PEG preparation both in terms of overall and right colon cleansing, with the advantage of a better tolerability and a good safety profile. In the future, this new preparation will be useful to improve adherence to CRC screening and surveillance programs.


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