Endoscopy 2019; 51(04): S158-S159
DOI: 10.1055/s-0039-1681638
ESGE Days 2019 ePoster podium presentations
Friday, April 5, 2019 14:00 – 14:30: Stomach ESD ePoster Podium 8
Georg Thieme Verlag KG Stuttgart · New York

CAN HELICOBACTER PYLORI ERRDICATION AFFECT OCCURRENCE OF METACHRONOUS GASTRIC TUMOR AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC TUMOR?

SH Kim
1   Gastroenterology of Internal Medicine, Eulji University/Eulji Hospital, Seoul, Korea, Republic of
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Publikationsverlauf

Publikationsdatum:
18. März 2019 (online)

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    Aims:

    metachronous gastric tumor (MGT) development has become a major problem after endoscopic resection. The relationship between helicobacter pylori eradication and MGT incidence rate has not been clarified. We evaluated the incidence, clinicopathologic features and the risk factors for MGT.

    Methods:

    From May 2008 to March 2013, we enrolled 260 patients (295 lesions) of gastric tumors which underwent ESD at EMC. Metachronous lesions were defined as secondary gastric neoplasms occurring at least 1 year after the initial ESD. We excluded 11 patients who have 22 synchronous lesions. Finally, a total of 249 patients (273 lesions) were enrolled this study. The 12 patients (31 lesions) were MGT and 237 patients (242 lesions) were single gastric tumor (SGT). We investigated the both patient factors and lesion factors. Lesion factors were tumor size, location, macroscopic finding and histological change.

    Results:

    The clinicopathologic features associated with MGT, including Helicobacter pylori infection (p = 0.40), histology (p = 0.47), tumor size (P = 0.28), depth (p = 0.4) and location (P > 0.99) were not significantly associated with MGT development. However, 70.45% of gastric tumors were occurred on the lower third, and 75% of MGT were developed on the same region (P > 0.99). 57.89% of MGT were developed on the same part of the stomach.

    Macroscopically elevated features (IIa) were associated with MGT development (P = 0.0014). Multivariate analysis exhibited no associations among the factors. The median period (SD) of the MGT development after ESD was 28.85 (14.3) months. And occurrence rate was 4.42% per year.

    Conclusions:

    There was no statistically significant correlation between MGT development and HP infection. großly flat elevated feature, only was considered as high risk of MGT development. However, two thirds of the early gastric tumors were likely to occur on the lower third of the stomach, and only half of the MGTs tended to develop on the same part of the stomach.