Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling

Abstract

N-Substituted dipropargylamines that are suitable as functionalized linkers for peptide stapling can be synthesized in one step under mild conditions from commercially available starting materials (41% to quantitative yield).

Key words

peptides - stapling - linkers - amines - alkynes - click chemistry

• References and Notes

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