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Semin Liver Dis 2020; 40(02): 180-188
DOI: 10.1055/s-0039-3402516
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Matrisome, Inflammation, and Liver Disease

Christine E. Dolin
1   Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky
,
Gavin E. Arteel
2   Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
3   Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania
› Author Affiliations
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Publication History

Publication Date:
07 January 2020 (online)

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Abstract

Chronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM) proteins (collagens) that ultimately impairs the function of the organ. The role of the ECM in early stages of chronic liver disease is less well-understood, but recent research has demonstrated that several changes in the hepatic ECM in prefibrotic liver disease are not only present but may also contribute to disease progression. The purpose of this review is to summarize the established and proposed changes to the hepatic ECM that may contribute to inflammation during earlier stages of disease development, and to discuss potential mechanisms by which these changes may mediate the progression of the disease.

Keywords

liver disease - hepatic - acute phase