COLONIC PERFORATION AFTER ROUTINE BIOPSY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Here we present two cases of colonic perforation after routine biopsy in patients with long-standing inflammatory-bowel-diseases. In vivo histology using a latest generation endocytoscope revealed crypt distension and deformity along with inflammatory cell infiltrates. After biopsy in the sigmoid colon with a standard biopsy forceps, small perforations occured, which were successfully managed by OTS-clipping. Conventional histology additionally showed fibrosis of the lamina propria along with atrophy of the entire colonic wall. Our cases demonstrate that biopsy-related perforation can occur in long-staining IBD without significant disease activity. Therefore, in vivo histology might help to minimize perforation risks in IBD patients.