DIAGNOSTIC YIELD OF MICRO-BIOPSY FORCEPS IN THE ASSESSMENT OF PERITONEAL CARCINOMATOSIS: A POSSIBLE NEW INDICATION?

Aims Peritoneal carcinomatosis is the metastatic seeding of tumoral cells on peritoneum, and it is associated with a dramatic prognosis worsening, with limited therapeutic opportunities. Therefore, PC should be ruled out before starting any invasive treatment modality. Recently, a new through-the-needle micro-biopsy forceps have been introduced, allowing micro-histology cores. We reported the preliminary experience, assessing patients with suspicious PC.

Methods Before liquid suction, the Moray forceps (MF) was introduced through a 19G FNA needle, and the suspected nodule was sampled. Micro-histology specimens were evaluated by a dedicated pathologist.

Results Three consecutive patients (2 F, 1 M; mean age 72 yo), with a suspicion of PC, referred for EUS staging, were sampled with MF. Tissue sampling was feasible in all patients, with a technical success of 100%. The sample quality was medium-high, in all the cases, giving the opportunity for immuno-histochemical staining, when necessary. No adverse events where observed both during and after the procedure in all cases.

Conclusions This is the first experience reporting a micro-histology forceps in the ascites work-out to rule out PC. The technique, using this through-the-needle device, is feasible and safe, with technical success rate of 100%. It allowed to sample peritoneal irregularity, with high quality tissue fragments in all the cases, giving the opportunity for additional assessment, as immunoistochemical staining.

 

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