Abstract
Catalytic C–H oxidation is a powerful transformation with enormous promise to streamline
access to complex molecules. In recent years, biocatalytic C–H oxidation strategies
have received tremendous attention due to their potential to address unmet regio-
and stereoselectivity challenges that are often encountered with the use of small-molecule-based
catalysts. This Account provides an overview of recent contributions from our laboratory
in this area, specifically in the use of iron- and α-ketoglutarate-dependent dioxygenases
in chemoenzymatic syntheses of complex natural products.
1 Introduction
2 Overview of Natural Oxygenases
3 C5 Hydroxylation of Aliphatic Amino Acids
4 Chemoenzymatic Synthesis of Tambromycin
5 Chemoenzymatic Synthesis of Cepafungin I and Related Analogues
6 Chemoenzymatic Synthesis of GE81112 B1 and Related Analogues
7 Conclusion and Future Direction
Key words
C–H hydroxylation - natural products - biocatalysis - total synthesis - amino acids
- oxygenases
