Formation of Imidazolones by Ring Closure of α-Isocyanoamides: Exploring New Reactivities

Abstract

Base-mediated ring closure of α,α-disubstituted α-isocyanoamides with further electrophilic trapping has previously been explored, but with limited applications. In this work, we wished to unravel the reactivities of these compounds and, in particular, to allow palladium-catalyzed coupling at the C2 position.

Key words

isocyanides - imidazolones - lithium compounds - palladium catalysis - coupling

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