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Journal of Pediatric Neurology 2021; 19(03): 202-203
DOI: 10.1055/s-0040-1714689
Case Report

Potential Role of Growth Hormone in a Pediatric Transient Ischemic Attack

David Farrier
1   Baylor College of Medicine, Houston, Texas, United States
,
Alexander J. Sandweiss 
2   Section of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States
,
Brittnie Bartlett
2   Section of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States
,
Farida Abid
2   Section of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States
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Abstract

Growth hormone (GH) is often prescribed in pediatric populations with short stature and is associated with several potential adverse events. One underrecognized potential adverse event is its effect on intracerebral vasculature, with concern for its ability to cause cerebrovascular accident. We present a pediatric case of presumed transient ischemic attack in the setting of chronic GH administration for idiopathic short stature syndrome. We propose potential pathogenic mechanisms for intracerebral vessel stenosis. We hope this case becomes a resource for clinicians and other healthcare providers when deciding whether or not to start GH in their young patients.

Keywords

stroke - aphasia - short stature syndrome

Informed Consent

Expressed and written consent was obtained by the patient's legal guardian, though no identifying information has been used.




Publication History

Received: 04 May 2020

Accepted: 24 June 2020

Article published online:
05 August 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Adil MM, Qureshi AI, Beslow LA, Jordan LC. Transient ischemic attack requiring hospitalization of children in the United States: kids' inpatient database 2003 to 2009. Stroke 2014; 45 (03) 887-888
    CrossrefPubMedGoogle Scholar
  • 2 Surmava AM, Maclagan LC, Khan F, Kapral MK, Hall RE, deVeber G. Incidence and current treatment gaps in pediatric stroke and TIA: an Ontario-wide population-based study. Neuroepidemiology 2019; 52 (3-4): 119-127
    CrossrefPubMedGoogle Scholar
  • 3 Poidvin A, Touzé E, Ecosse E. et al. Growth hormone treatment for childhood short stature and risk of stroke in early adulthood. Neurology 2014; 83 (09) 780-786
    CrossrefPubMedGoogle Scholar
  • 4 Child CJ, Zimmermann AG, Chrousos GP. et al. Safety outcomes during pediatric GH therapy: final results from the prospective GeNeSIS observational program. J Clin Endocrinol Metab 2019; 104 (02) 379-389
    CrossrefPubMedGoogle Scholar
  • 5 Mosca S, Paolillo S, Colao A. et al. Cardiovascular involvement in patients affected by acromegaly: an appraisal. Int J Cardiol 2013; 167 (05) 1712-1718
    CrossrefPubMedGoogle Scholar
  • 6 Rizzoni D, Porteri E, Giustina A. et al. Acromegalic patients show the presence of hypertrophic remodeling of subcutaneous small resistance arteries. Hypertension 2004; 43 (03) 561-565
    CrossrefPubMedGoogle Scholar
  • 7 Brevetti G, Marzullo P, Silvestro A. et al. Early vascular alterations in acromegaly. J Clin Endocrinol Metab 2002; 87 (07) 3174-3179
    CrossrefPubMedGoogle Scholar