Role of Benzylic Deprotonation in Nickel-Catalyzed Benzylic Dehydrogenation

Abstract

Alkylarenes are readily functionalized via the corresponding benzylic anions. Benzylic anions have been used for a range of catalytic reactions, including Ni-catalyzed dehydrogenation. Interestingly, the employment of Zn(TMP)₂ for slow and incomplete deprotonation of the benzylic position was observed. This manuscript describes a preliminary investigation into the deprotonation of heteroarenes and its relationship to Ni-catalyzed benzylic dehydrogenation.

Key words

Ni catalysis - dehydrogenation - benzylic anion - heteroarene - deuteration

Publikationsverlauf

Eingereicht: 13. Mai 2021

Angenommen: 09. Juni 2021

Artikel online veröffentlicht:
15. Juli 2021

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More examples:
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