Kurzdarmsyndrom und Darmversagen – neue Entwicklungen

Zusammenfassung

Das Darmversagen wird von den intestinalen Flüssigkeits- und Elektrolytverlusten sowie von der ungenügenden Resorption von Makronährstoffen bestimmt und bedarf oft der individuell zusammengestellen parenteralen Substitution (sogn. Compounding). Mit Teduglutid als stabiles GLP2-Analogon steht eine medikamentöse Therapie zur Verfügung, die die Resorptionsleistung verbessert und so zu infusionsfreien Tagen führen kann. Katheterinfektionen sind die häufigste Komplikation der parenteralen Substitution. Ihre Häufigkeit kann durch Taurolidin als Katheterblocklösung reduziert werden.

Abstract

Intestinal failure is characterized by intestinal water and electrolyte losses as well as malabsorption of macronutrients. It often requires individually composed parenteral support (so call compounding). Teduglutide, a DPP-IV resistant GLP2 analogue, is available a pharmacologic treatment, which stimulates intestinal absorption and can facilitate infusion free days. Catheter infections are the most common complication of home parenteral support. The incidence can be minimized using Taurolidin as a catheter block solution.

Schlüsselwörter

Kurzdarmsyndrom - Darmversagen - Kathetersepsis

Keywords

short bowel syndrome - intestinal failure - catheter sepsis

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