Digestive Disease Interventions 2021; 05(02): 153-161
DOI: 10.1055/s-0041-1723805
Review Article

Holmium-166 Radioembolization

Autoren

  • Marnix G. E. H. Lam

    1   Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
  • Maarten L. J. Smits

    1   Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
  • Rutger C. G. Bruijnen

    1   Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
  • Bart de Keizer

    1   Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
  • Arthur J. A. T. Braat

    1   Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

Radioembolization is usually performed with microspheres containing yttrium-90 (90Y). Holmium-166 (166Ho)-microspheres were developed as an alternative new product for radioembolization. The unique characteristics of 166Ho-microspheres allow for improved imaging possibilities. They can be visualized and quantified, already at low numbers and activities, to predict treatment distribution using 166Ho-microspheres at scout quantity during pre-treatment simulation. The option to reliably predict the distribution of microspheres provides physicians control over the treatment, allowing them to select and treat patients with a personalized treatment plan. Safety and efficacy were established in several clinical studies. 166Ho-microspheres radioembolization aims to optimize individualized treatment planning in order to improve treatment outcomes.



Publikationsverlauf

Eingereicht: 03. Dezember 2020

Angenommen: 22. Dezember 2020

Artikel online veröffentlicht:
15. April 2021

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