Endoscopy 2021; 53(S 01): S55
DOI: 10.1055/s-0041-1724395
Abstracts | ESGE Days
ESGE Days 2021 Oral presentations
Friday, 26 March 2021 15:00 – 15:45 Tackling the tricky biliary stricture Room 5

A New Tool For Bile Duct Tissue Sampling: Ex-Vivo Clinical Evaluation of Intraductal Cryobiopsy for Cholangioscopy

Authors

  • L Wirsing

    1   Robert-Bosch-Hospital, Department of Gastroenterology, Hepatology and Endocrinology, Stuttgart, Germany

  • W Linzenbold

    2   ERBE Elektromedizin GmbH, Tuebingen, Germany

  • M Enderle

    2   ERBE Elektromedizin GmbH, Tuebingen, Germany

  • P Stahl

    3   Robert-Bosch-Hospital, Institute of Pathology, Stuttgart, Germany

  • W Traenkenschuh

    3   Robert-Bosch-Hospital, Institute of Pathology, Stuttgart, Germany

  • T Leibold

    4   Robert-Bosch-Hospital, Department of Surgery, Stuttgart, Germany

  • J Albert

    1   Robert-Bosch-Hospital, Department of Gastroenterology, Hepatology and Endocrinology, Stuttgart, Germany

  • J Peveling-Oberhag

    1   Robert-Bosch-Hospital, Department of Gastroenterology, Hepatology and Endocrinology, Stuttgart, Germany
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    Aims Indeterminate biliary strictures (IBS) represent a major challenge in clinical diagnostics today. Diagnostic yield of radiological and endoscopic imaging is insufficient, and histopathological diagnosis based on in-vivo biopsy technique is ambiguous in many cases. The cryobiopsy technique (CB) is a new method for tissue extraction, which is already used for endobronchial biopsies in clinical routine.

    The aim of this ex-vivo clinical study was to investigate feasibility and tissue quality of CB in comparison to standard biopsy forceps for the retrieval of native and pathologically altered bile duct tissue.

    Methods We included 14 patients with suspected tumor obstruction of the common bile duct who underwent pancreaticoduodenectomy. Tissue samples were taken from either visibly altered areas or native bile duct. A new prototype of a cryoprobe as well as standard forceps (cholangioscopic forceps CF or gastric biopsy forceps GBF) were used for comparison. All biopsy specimens were assessed by two pathologists blinded to the biopsy method. Data was collected and analyzed for general feasibility, specimen area, and histological assessability as well as representativity of tissue.

    Results CB success rate was superior to CF (p=0.0022). There was no statistical difference between CB and GBF concerning feasibility (p=0.2096). Significantly larger tissue samples were obtained with CB compared to GBF (p=0.005). CB was superior in histological assessment quality compared to pooled forceps (p=0.0302) and concerning representativity (p=0.0225).

    Conclusions CB in the bile duct is feasible and the quality of the obtained tissue is high. Larger tissue amounts and more representative samples can be retrieved than with a standard biopsy forceps. With these promising results, an in-vivo study should be initiated.

    Citation: Wirsing L, Linzenbold W, Enderle M et al. OP134 A NEW TOOL FOR BILE DUCT TISSUE SAMPLING: EX-VIVO CLINICAL EVALUATION OF INTRADUCTAL CRYOBIOPSY FOR CHOLANGIOSCOPY. Endoscopy 2021; 53: S55.


     

    Publication History

    Article published online:
    19 March 2021

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