Radiation-Induced Tissue Damage: Clinical Consequences and Current Treatment Options

Hillary Nepon; Tyler Safran; Edward M. Reece; Amanda M. Murphy; Joshua Vorstenbosch; Peter G. Davison

doi:10.1055/s-0041-1731464

Seminars in Plastic Surgery, Inhaltsverzeichnis

Semin Plast Surg 2021; 35(03): 181-188
DOI: 10.1055/s-0041-1731464

Review Article

Radiation-Induced Tissue Damage: Clinical Consequences and Current Treatment Options

Hillary Nepon

¹Division of Experimental Surgery, McGill University, Montreal, Quebec, Canada

,

Tyler Safran

²Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada

,

Edward M. Reece

³Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas

,

Amanda M. Murphy

²Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada

,

Joshua Vorstenbosch

²Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada

,

Peter G. Davison

²Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada

› Institutsangaben

Abstract

Radiation therapy is a valuable tool in the treatment of numerous malignancies but, in certain cases, can also causes significant acute and chronic damage to noncancerous neighboring tissues. This review focuses on the pathophysiology of radiation-induced damage and the clinical implications it has for plastic surgeons across breast reconstruction, osteoradionecrosis, radiation-induced skin cancers, and wound healing. The current understanding of treatment modalities presented here include hyperbaric oxygen therapy, autologous fat grafting and stem cells, and pharmaceutical agents.

Keywords

radiation therapy - fibrosis - radiation damage

Volltext

Referenzen

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