Homeopathy 2022; 111(03): 210-216
DOI: 10.1055/s-0041-1732306
Debate Article

The Electrostatic Model of Homeopathy: The Mechanism of Physicochemical Activities of Homeopathic Medicines

1   Ric Scalzo Botanical Research Institute, Southwest College of Naturopathic Medicine and Health Sciences, Tempe, Arizona, United States
2   Bioscientific LLC, Los Angeles, California, United States
,
John P. Borneman
3   Standard Homeopathic Company, Hyland's Inc., Los Angeles, California, United States
› Author Affiliations

Abstract

This paper attempts to propose a model, called the electrostatic model of homeopathy, to explain a mechanism for the physicochemical activities of highly diluted homeopathic medicines (HMs). According to this proposed model, the source of HMs' action is dipole orientations as electrostatic imprints of the original molecules carried by diluent molecules (such as sugar molecules) or potentization-induced aqueous nanostructures. The nanoscale domains' contact charging and dielectric hysteresis play critical roles in the aqueous nanostructures' or sugar molecules' acquisition of the original molecules' dipole orientations. The mechanical stress induced by dynamization (vigorous agitation or trituration) is a crucial factor that facilitates these phenomena. After dynamization is completed, the transferred charges revert to their previous positions but, due to dielectric hysteresis, they leave a remnant polarization on the aqueous nanostructures or sugar molecules' nanoscale domains. This causes some nanoscale domains of the aqueous nanostructures or sugar molecules to obtain the original substance molecules' dipole orientations. A highly diluted HM may have no molecule of the original substance, but the aqueous nanostructures or sugar molecules may contain the original substance's dipole orientations. Therefore, HMs can precisely aim at the biological targets of the original substance molecules and electrostatically interact with them as mild stimuli.



Publication History

Received: 30 March 2021

Accepted: 03 June 2021

Article published online:
11 October 2021

© 2021. Faculty of Homeopathy. This article is published by Thieme.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Bellavite P, Conforti A, Piasere V, Ortolani R. Immunology and homeopathy. 1. Historical background. Evid Based Complement Alternat Med 2005; 2: 441-452
  • 2 Loudon I. A brief history of homeopathy. J R Soc Med 2006; 99: 607-610
  • 3 Shahabi S, Kasariyans A, Noorbakhsh F. Like cures like: a neuroimmunological model based on electromagnetic resonance. Electromagn Biol Med 2013; 32: 508-526
  • 4 Shahabi S. Memory of Water and Law of Similars; Making Sense Out of Homeopathy. In: Rosch P. ed. Bioelectromagnetic and Subtle Energy Medicine. 2nd ed.. London: CRC Press; 2015
  • 5 Zastrow Mv. Drug receptors & pharmacodynamics. In: Katzung BG. ed. Basic and Clinical Pharmacology. 14th ed.. New York: McGraw Hill Educational; 2017
  • 6 Kangas E, Tidor B. Electrostatic specificity in molecular ligand design. J Chem Phys 2000; 112: 9120-9130
  • 7 Davis SJ, Davies EA, Tucknott MG, Jones EY, van der Merwe PA. The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2. Proc Natl Acad Sci U S A 1998; 95: 5490-5494
  • 8 Christofi AM, Garratt PJ, Hogarth G. et al. Molecular design using electrostatic interactions. Part 4: Synthesis and properties of flexible tetrapodand tetracations derived from naphthalene. Role of structured water in the electrostatic binding of polyanion guests: a model for interactions in biological systems. Tetrahedron 2002; 58: 4543-4549
  • 9 Rubinstein A, Sabirianov RF, Mei WN, Namavar F, Khoynezhad A. Effect of the ordered interfacial water layer in protein complex formation: a nonlocal electrostatic approach. Phys Rev E Stat Nonlin Soft Matter Phys 2010; 82: 021915
  • 10 Pal SK, Peon J, Bagchi B. et al. Biological Water: Femtosecond dynamics of macromolecular hydration. Phys Chem B; 2002. 48. 12376-12395
  • 11 Pazur A. Calcium ion cyclotron resonance in dissipative water structures. Electromagn Biol Med 2018; 37: 100-113
  • 12 De Ninno A, Castellano AC, Del Giudice E. The Supramolecular Structure of Liquid Water and Quantum Coherent Processes in Biology. Bristol: Journal of Physics: Conference Series. IOP Publishing; 2013: 012031
  • 13 Persch E, Dumele O, Diederich F. Molecular recognition in chemical and biological systems. Angew Chem Int Ed Engl 2015; 54: 3290-3327
  • 14 Bunik V, Raddatz G, Lemaire S, Meyer Y, Jacquot JP, Bisswanger H. Interaction of thioredoxins with target proteins: role of particular structural elements and electrostatic properties of thioredoxins in their interplay with 2-oxoacid dehydrogenase complexes. Protein Sci 1999; 8: 65-74
  • 15 Morosinotto T, Breton J, Bassi R, Croce R. The nature of a chlorophyll ligand in Lhca proteins determines the far red fluorescence emission typical of photosystem I. J Biol Chem 2003; 278: 49223-49229
  • 16 Burda JV, Šponer J, Leszczynski J, Hobza P. Interaction of DNA base pairs with various metal cations (Mg2+, Ca2+, Sr2+, Ba2+, Cu+, Ag+, Au+, Zn2+, Cd2+, and Hg2+): nonempirical ab initio calculations on structures, energies, and nonadditivity of the interaction. J Phys Chem B 1997; 101: 9670-9677
  • 17 Tu Y, Zhou R, Fang H. Signal transmission, conversion and multiplication by polar molecules confined in nanochannels. Nanoscale 2010; 2: 1976-1983
  • 18 Kayne SB. Homeopathic Pharmacy: Theory and Practice. 2nd ed.. Edinburgh; New York: Elsevier Churchill Livingstone; 2006
  • 19 Bystrov V, Seyedhosseini E, Kopyl S. et al. Piezoelectricity and ferroelectricity in biomaterials: molecular modeling and piezoresponse force microscopy measurements. J Appl Phys 14 116: 066803
  • 20 Boddu V, Endres F, Steinmann P. Molecular dynamics study of ferroelectric domain nucleation and domain switching dynamics. Sci Rep 2017; 7: 806
  • 21 Gorshunov BP, Torgashev VI, Zhukova ES. et al. Incipient ferroelectricity of water molecules confined to nano-channels of beryl. Nat Commun 2016; 7: 12842
  • 22 Bertotti G, Mayergoyz ID. The Science of Hysteresis: 3-Volume Set. Elsevier; 2005
  • 23 Damjanovic D. Hysteresis in piezoelectric and ferroelectric materials. In: Mayergoyz I, Bertotti G. eds. The Science of Hysteresis. 1st ed.. Kidlington Academic Press; 2005
  • 24 Chen WJ, Yuan S, Ma LL. et al. Mechanical switching in ferroelectrics by shear stress and its implications on charged domain wall generation and vortex memory devices. RSC Advances 2018; 8: 4434-4444
  • 25 Chen Z, Qianwei H, Feifei W. et al. Stress-induced reversible and irreversible ferroelectric domain switching. Appl Phys Lett 2018; 112: 152901
  • 26 Baryshnikov S, Charnaya E, Stukova E. et al. Ferroelectricity in Rochelle salt nanoparticles confined to porous alumina. Ferroelectrics 2010; 396: 3-9
  • 27 Cui C, Xue F, Hu WJ. et al. Two-dimensional materials with piezoelectric and ferroelectric functionalities. Math Appl 2018; 2: 18
  • 28 Miao H, Tan C, Zhou X. et al. More ferroelectrics discovered by switching spectroscopy piezoresponse force microscopy?. EPL 2014; 108: 27010
  • 29 Vasudevan RK, Balke N, Maksymovych P. et al. Ferroelectric or non-ferroelectric: why so many materials exhibit “ferroelectricity” on the nanoscale. Appl Phys Rev 2017; 4: 021302
  • 30 Bae J-H, Kwon D, Jeon N. et al. Highly scaled, high endurance, Ω-gate, nanowire ferroelectric FET memory transistors. IEEE Electron Device Lett 2020; 41: 1637-1640
  • 31 Schein LB, Castle GP, Lacks DJ. Triboelectrification. Wiley Encyclopedia of Electrical and Electronics Engineering; 1999. 4. 1-14
  • 32 Friend M, Kohn J. Fundamentals of Occupational Safety and Health. 4th ed.. Lanham: Government Institutes: 2007
  • 33 Wang M, Pan J, Wang M. et al. High-performance triboelectric nanogenerators based on a mechanoradical mechanism. ACS Sustain Chem& Eng 2020; 8: 3865-3871
  • 34 Seol M-L, Han J-W, Moon D-I. et al. Hysteretic behavior of contact force response in triboelectric nanogenerator. Nano Energy 2017; 32: 408-413
  • 35 Cacace C, Elia L, Elia V. et al. Conductometric and pHmetric titrations of extremely diluted solutions using HCl solutions as titrant: a molecular model. J Mol Liq 2009; 146: 122-126
  • 36 Elia V, Napoli E, Niccoli M. A molecular model of interaction between extremely diluted solutions and NaOH solutions used as titrant: conductometric and pHmetric titrations. J Mol Liq 2009; 148: 45-50
  • 37 Elia V, Napoli E, Niccoli M. Thermodynamic parameters for the binding process of the OH ion with the dissipative structures. Calorimetric and conductometric titrations. J Therm Analysis Calorim 2010; 102: 1111-1118
  • 38 Elia V, Ausanio G, Gentile F, Germano R, Napoli E, Niccoli M. Experimental evidence of stable water nanostructures in extremely dilute solutions, at standard pressure and temperature. Homeopathy 2014; 103: 44-50
  • 39 Yinnon T, Kalia K, Kikar D. Very dilute aqueous solutions—structural and electromagnetic phenomena. Water 2017; 9: 28-66
  • 40 Ryzhkina I, Murtazina L, Kiseleva YV. et al. Self-organization and physicochemical properties of aqueous solutions of the antibodies to interferon gamma at ultrahigh dilution. Dokl Phys Chem 2015; 462: 110-114
  • 41 Mahata CR. Dielectric dispersion studies of some potentised homeopathic medicines reveal structured vehicle. Homeopathy 2013; 102: 262-267
  • 42 Elia V, Marrari L, Napoli E. Aqueous nanostructures in water induced by electromagnetic fields emitted by EDS: A conductometric study of fullerene and carbon nanotube EDS. J Therm Analysis Calorim 2012; 107: 843-851
  • 43 Samal S, Geckeler KE. Unexpected solute aggregation in water on dilution. Chem Commun (Camb) 2001; 21: 2224-2225
  • 44 Elia V, Niccoli M. New physico-chemical properties of extremely diluted aqueous solutions. J Therm Analysis Calorim 2004; 75: 815-836
  • 45 Elia V, Marchese M, Montanino M. et al. Hydrohysteretic phenomena of “extremely diluted solutions” induced by mechanical treatments: a calorimetric and conductometric study at 25°C. J Solution Chem 2005; 34: 947-960
  • 46 Elia V, Napoli E, Niccoli M. et al. New physico-chemical properties of extremely dilute solutions. A conductivity study at 25° C in relation to ageing. J Solution Chem 2008; 37: 85-96
  • 47 Elia V, Elia L, Marchettini N. et al. Physico-chemical properties of aqueous extremely diluted solutions in relation to ageing. J Therm Analysis Calorim 2008; 93: 1003-1011
  • 48 Konovalov A, Ryzhkina I. Formation of nanoassociates as a key to understanding of physicochemical and biological properties of highly dilute aqueous solutions. Russ Chem Bull 2014; 63: 1-14
  • 49 Lobyshev VI, Tomkevich MS, Petrushanko IIu. An experimental study of potentiated aqueous solutions. Biofizika 2005; 50: 464-469
  • 50 Belon P, Elia V, Elia L. et al. Conductometric and calorimetric studies of the serially diluted and agitated solutions. J Therm Analysis Calorim 2008; 93: 459-469
  • 51 Miranda A, Vannucci A, Pontuschka W. Impedance spectroscopy of water in comparison with high dilutions of lithium chloride. Mater Res Innov 2011; 15: 302-309
  • 52 Vybíral B, Vorácek P. Long term structural effects in water: autothixotropy of water and its hysteresis. Homeopathy 2007; 96: 183-188
  • 53 Kaiser F. External signals and internal oscillation dynamics: biophysical aspects and modelling approaches for interactions of weak electromagnetic fields at the cellular level. Bioelectrochem Bioenerg 1996; 41: 3-18
  • 54 Pohanka M. The piezoelectric biosensors: principles and applications. Int J Electrochem Sci 2017; 12: 496-506
  • 55 Prahl LS, Shelton DP. The Search for Ferroelectric Domain Structures in Carbohydrate Glasses Using Atomic Force Microscopy. Poster presented at: Undergraduate Research Opportunities Program (UROP). ; June 20, 2008; Las Vegas, NV
  • 56 Liboff AR. The ion cyclotron resonance hypothesis. In: Greenebaum B, Barnes FS. eds. Bioengineering and Biophysical Aspects of Electromagnetic Fields. 3rd ed.. CRC Press; 2018: 261-292
  • 57 Preparata G. Quantum field theory of the free-electron laser. Phys Rev A Gen Phys 1988; 38: 233-237
  • 58 Tournier A, Würtenberger S, Klein SD, Baumgartner S. Physicochemical investigations of homeopathic preparations: a systematic review and bibliometric analysis–Part 3. J Altern Complement Med 2021; 27: 45-57
  • 59 Cartwright SJ. Homeopathic potencies may possess an electric field (-like) component: evidence from the use of encapsulated solvatochromic dyes. Homeopathy 2020; 109: 14-22
  • 60 Cartwright SJ. Degree of response to homeopathic potencies correlates with dipole moment size in molecular detectors: implications for understanding the fundamental nature of serially diluted and succussed solutions. Homeopathy 2018; 107: 19-31
  • 61 Cartwright SJ. Interaction of homeopathic potencies with the water soluble solvatochromic dye bis-dimethylaminofuchsone. Part 1: pH studies. Homeopathy 2017; 106: 37-46
  • 62 Cartwright SJ. Solvatochromic dyes detect the presence of homeopathic potencies. Homeopathy 2016; 105: 55-65