Download PDF
B&G Bewegungstherapie und Gesundheitssport 2016; 32(02): 45-49
DOI: 10.1055/s-0042-103395
Wissenschaft
Haug Verlag in Georg Thieme Verlag KG Stuttgart

Erhalt der Ausdauer und Mobilität während alloHZT

M. Limbach
1   Klinik für Innere Medizin I, Schwerpunkt Hämatologie, Onkologie und Stammzellentransplantation, Universitätsklinikum Freiburg
2   AG „Onkologische Sport- und Bewegungstherapie“ Abteilung Medizinische Onkologie am Nationalen Centrum für Tumorerkrankungen und Universitätsklinikum Heidelberg
,
A. Wehrle
3   Institut für Bewegungs- und Arbeitsmedizin, Universitätsklinikum Freiburg
› Author Affiliations
Further Information

Publication History

Eingegangen: 14 January 2016

Angenommen durch Review: 29 January 2016

Publication Date:
12 April 2016 (online)

    Permissions and Reprints

Zusammenfassung

Als Folge einer allogenen hämatopoetischen Zelltransplantation (alloHZT) kann es zu zahlreichen Nebenwirkungen kommen, die eine Abnahme der körperlichen Leistungsfähigkeit (LF) bedingen. Ziel der randomisierten Pilotstudie (n = 13) war es, die LF durch ein Ausdauer- oder Gleichgewichtstraining zu erhalten und anhand aktueller Erhebungsmethoden zu untersuchen. Insgesamt kam es trotz einer bewegungstherapeutischen Intervention zu einer Reduktion der LF. Während die Messungen gut toleriert wurden, scheint die Toxizität der Behandlung und die therapieinduzierte Immobilisation normale kardiovaskuläre und muskuloskelettale Adaptionen durch Training stark zu beeinträchtigen und Schwächen der aeroben Kapazität herbeizuführen.

Summary

Preservation of endurance and mobility during allogeneic hematopoietic cell transplantation (alloHCT)

As a consequence of alloHCT, various side effects occur which lead to the decline of physical capability. The aim of this randomized pilot study (n = 13) was the preservation of the physical capability through endurance exercise or balance training and to investigate adaption to the new recommendations for assessment methods. Overall, there was a reduction of the physical capability despite therapeutic exercises. Whereas the assessment methods were well tolerated, the toxic therapy and the therapy-induced immobilization seemed to have altered normal cardiovascular und musculoskeletal training adaption and led to the weakness of aerobic capacity.

Stichworte:

Allogene hämatopoetische Zelltransplantation - Ausdauertraining - Gleichgewichtstraining - Erhebungsmethoden

Key words:

allogeneic hematopoietic stem cell transplantation - endurance exercise - balance training - assessment methods
 

  • Literatur

  • 1 Baker KS, Armenian S, Bhatia S. Long-term consequences of hematopoietic stem cell transplantation: current state of the science. Biol Blood Marrow Transplant 2010; 16 (Suppl. 01) 90-96
    CrossrefPubMedGoogle Scholar
  • 2 Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med 2006; 354 (17): 1813-1826
    CrossrefPubMedGoogle Scholar
  • 3 Gram M, Dahl R, Dela F. Physical inactivity and muscle oxidative capacity in humans. Eur J Sport Sci 2014; 14 (4): 376-383
    CrossrefPubMedGoogle Scholar
  • 4 Granacher U, Gruber M, Strass D et al. Auswirkungen von Sensomotorischem Training im Alter auf die Maximal- und Explosivkraft. DZSM 2007; 58 (12): 446-451
    PubMedGoogle Scholar
  • 5 Klassen O, Schmidt ME, Scharhag-Rosenberger F et al. Cardiorespiratory fitness in breast cancer patients undergoing adjuvant therapy. Acta Oncol 2014; 53 (10): 1356-1365
    CrossrefPubMedGoogle Scholar
  • 6 Kouzaki M, Masani K, Akima H et al. Effects of 20-day bed rest with and without strength training on postural sway during quiet standing. Acta Physiol (Oxf) 2007; 189 (3): 279-292
    CrossrefPubMedGoogle Scholar
  • 7 Kovalszki A, Schumaker GL, Klein A et al. Reduced respiratory and skeletal muscle strength in survivors of sibling or unrelated donor hematopoietic stem cell transplantation. Bone Marrow Transplant 2008; 41 (11): 965-969
    CrossrefPubMedGoogle Scholar
  • 8 Kuehl R, Scharhag-Rosenberger F, Schommer K et al. Exercise intensity classification in cancer patients undergoing allogeneic HCT. Med Sci Sports Exerc 2015; 47 (5): 889-895
    CrossrefPubMedGoogle Scholar
  • 9 Mezzani A, Agostoni P, Cohen-Solal A et al. Standards for the use of cardiopulmonary exercise testing for the functional evaluation of cardiac patients: a report from the Exercise Physiology Section of the European Association for Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil 2009; 16 (3): 249-267
    CrossrefPubMedGoogle Scholar
  • 10 Muffly L. Patient selection for allogeneic hematopoietic cell transplantation (HCT): the evolution of HCT risk assessment. Curr Hematol Malig Rep 2015; 10 (1): 28-34
    CrossrefPubMedGoogle Scholar
  • 11 Muir J, Judex S, Qin YX et al. Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals. Gait Posture 2011; 33 (3): 429-435
    CrossrefPubMedGoogle Scholar
  • 12 Paterson DH, Cunningham DA, Koval JJ et al. Aerobic fitness in a population of independently living men and women aged 55–86 years. Med Sci Sports Exerc 1999; 31 (12): 1813-1820
    CrossrefPubMedGoogle Scholar
  • 13 Persoon S, Kersten MJ, van der Weiden K et al. Effects of exercise in patients treated with stem cell transplantation for a hematologic malignancy: a systematic review and meta-analysis. Cancer Treat Rev 2013; 39 (6): 682-690
    CrossrefPubMedGoogle Scholar
  • 14 Roecker K. Die sportmedizinische Laktatdiagnostik: Technische Rahmenbedingungen und Einsatzbereiche. Deutsche Zeitschrift für Sportmedizin 2013; 64 (12): 267- 371
    PubMedGoogle Scholar
  • 15 Scharhag-Rosenberger F. Spiroergometrie zur Ausdauerleistungsdiagnostik. Deutsche Zeitschrift für Sportmedizin 2010; 61 (6): 146-147
    PubMedGoogle Scholar
  • 16 Scharhag-Rosenberger F, Becker T, Streckmann F et al. Studien zu körperlichem Training bei onkologischen Patienten: Empfehlungen zu den Erhebungsmethoden. DZSM 2014; 65 (11): 304-313
    PubMedGoogle Scholar
  • 17 Schenkman M, Hughes MA, Samsa G et al. The relative importance of strength and balance in chair rise by functionally impaired older individuals. J Am Geriatr Soc 1996; 44 (12): 1441-1446
    CrossrefPubMedGoogle Scholar
  • 18 Schmitz KH, Courneya KS, Matthews C et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 2010; 42 (7): 1409-1426
    CrossrefPubMedGoogle Scholar
  • 19 Streckmann F, Kneis S, Leifert JA et al. Exercise program improves therapy-related side-effects and quality of life in lymphoma patients undergoing therapy. Ann Oncol 2014; 25 (2): 493-499
    CrossrefPubMedGoogle Scholar
  • 20 Streckmann F, Zopf EM, Lehmann HC et al. Exercise intervention studies in patients with peripheral neuropathy: a systematic review. Sports Med 2014; 44 (9): 1289-1304
    CrossrefPubMedGoogle Scholar
  • 21 White AC, Terrin N, Miller KB et al. Impaired respiratory and skeletal muscle strength in patients prior to hematopoietic stem-cell transplantation. Chest 2005; 128 (1): 145-152
    CrossrefPubMedGoogle Scholar
  • 22 Wiskemann J, Dreger P, Schwerdtfeger R et al. Effects of a partly self-administered exercise program before, during and after allogeneic stem cell transplantation. Blood 2011; 117 (9): 2604-2613
    CrossrefPubMedGoogle Scholar
  • 23 Wiskemann J, Kleindienst N, Kuehl R et al. Effects of physical exercise on survival after allogeneic stem cell transplantation. Int J Cancer 2015; 137 (11): 2749-5276
    CrossrefPubMedGoogle Scholar
  • 24 Wiskemann J, Kuehl R, Dreger P et al. Efficacy of exercise training in SCT patients – who benefits most?. Bone Marrow Transplant 2014; 49 (3): 443-448
    CrossrefPubMedGoogle Scholar
  • 25 Wood WA, Deal AM, Reeve BB et al. Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study. Bone Marrow Transplant 2013; 48 (10): 1342-1349
    CrossrefPubMedGoogle Scholar