Aktuelles aus der Forschung

Behandlung mit Rituximab nach Absetzen von Natalizumab

Aufgrund des PML-Risikos können JCV-Antikörper positive Patienten nur eine begrenzte Zeit mit Natalizumab behandelt werden. Nach wie vor stellt die Umstellung auf eine alternative Therapie eine klinische Herausforderung dar, da es bei diesen Patienten mit hochaktiver MS häufig zu einer Reaktivierung der Erkrankungsaktivität kommt. Bisherige Ansätze mit überbrückender Steroidstoßtherapie, Interferon-beta, Glatiramerazetat oder Fingolimod hatten nur eine begrenzte Wirksamkeit [1].

• Literatur

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