Erfahrungsheilkunde 2016; 65(04): 206-212
DOI: 10.1055/s-0042-109039
Praxis
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Vitamin A: Retinolpalmitat

Further Information

Publication History

Publication Date:
30 August 2016 (online)

Zusammenfassung

Retinolpalmitat bzw. Vitamin A gehört zu den „vergessenen“ Nährstoffen, weil es als Vitamin mit selten anzutreffendem Mangel gilt und in Therapiestudien außerhalb der Dermatologie wenig signifikante Ergebnisse erzielt wurden. In der orthomolekularen Medizin sollte Vitamin A und die therapeutisch gezielte Gabe von Retinolpalmitat wieder mehr beachtet werden. Dabei ist ein Mangel durch vegane Ernährung, Darmresorptionsstörungen und Lebererkrankungen genauso zu berücksichtigen wie eine gezielte hochdosierte redifferenzierende oder komplementäre Therapie in der Onkologie.

Abstract

Retinol or Vitamin A is one of the „forgotten“ micronutrients because it is considered a vitamin with rare deficiency and in clinical studies outside of dermatology pour results were obtained. In the good orthomolecular medicine Vitamin A and therapeutically targeted administration of retinol should be noted again more . Deficiency by veganism, bowel resorption disorders and liver disease is as to note as a specific high-dose redifferentiating or complementary therapy in oncology.

 
  • Literatur

  • 1 Berg WJ, Schwartz LH, Amsterdam A et al. A phase II study of 13-cis-retinoic acid in patients with advanced renal cell carcinoma. Invest New Drugs 1997; 15: 353-555
  • 2 Ehrenpreis ED et al. Disease of the Colon and Rectum. 2005 48. 1-8
  • 3 Escudier B, Ravaud A, Berton D et al. Phase II study of interferon-alpha and all-trans retinoic acid in metastatic renal cell carcinoma. J Immunother 1998; 21: 62-64
  • 4 Feskanich D, Singh V, Willett WC et al. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002; 287: 47-54
  • 5 Formelli F, Cleris L. Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity. Cancer research 1993; 53: 5374-5376
  • 6 Goss GD, McBurney MW. Physiological and clinical aspects of vitamin A and its metabolites. Crit Rev Clin Lab Sci 1992; 185-215
  • 7 Guo X, Nanus DM, Ruiz A et al. Reduced levels of retinyl esters and vitamin A in Human Renal Cancers. Cancer Res 2001; 61: 2774-2781
  • 8 Hallum AV, Alberts DS, Lippman SM et al. Phase II study of 13-cis-retinoic acid plus interferon-α2a in heavily pretreated squamous carcinoma of the cervix. Gynecologic oncology 1995; 56: 382-386
  • 9 Hönig-dOrville I. Retinoide in der Therapie des metastasierten Nierenzellkarzinoms: Untersuchungen am Modell multizellulärer Tumorsphäroide. Dissertation Medizinische Fakultät TH Aachen 2003.
  • 10 Hu F, Wu Z, Li G et al. The plasma level of retinol, vitamins A, C and α-tocopherol could reduce breast cancer risk? A meta-analysis and meta-regression. Journal of cancer research and clinical oncology 2015; 141: 601-614
  • 11 Hübner J, Münstedt P, Micke O et al. Faktenblatt: Betacarotin und Vitamin A der PRIO (Prävention und Integrative Onkologie) 2015.
  • 12 Hunter DJ, Willett W, Blomhoff R. Vitamin A and cancer. Epidemiological evidence in humans. Vitamin A in health and disease. 1994: 561-584
  • 13 Issing WJ, Struck R, Naumann A et al. High concentrate A-mulsin, a new therapy concept in laryngeal leukoplakia. Laryngo-rhino-otologie 1996; 75: 29-33
  • 14 Jyothirmayi R, Ramadas K, Varghese C et al. Efficacy of vitamin A in the prevention of loco- regional recurrence and second primaries in head and neck cancer. Eur J Cancer BOral Oncol 1996; 373-376
  • 15 Kerscher M, Williams S. Hautalterung und Vitamine. In: Fortschritte der praktischen Dermatologie und Venerologie. Heidelberg: Springer; 2005
  • 16 Kiemle-Kalle J, Porzsolt F. Retinoide in der Onkologie. Dtsch Med Wschr 1993; 390-394
  • 17 KimJH Ki, Kim SH, He SQ et al. Use of vitamins as adjunct to conventional cancer therapy. In Nutrients in Cancer Prevention and Treatment 1995; 363-372
  • 18 Koletzko B, Koletzko S. Ernährung bei cystischer Fibrose. In: In: Cystische Fibrose. Heidelberg: Springer; 2001
  • 19 Kucera H. Adjuvanticity of vitamin A in advanced irradiated cervical cancer. Wien Klin Wochenschr Suppl 1980; 118: 1-20
  • 20 Laaksorvitra S, Rajala P, Nurmi M et al. The cytostatic effect of 9-cis-retinoic acid, tretinoin, and isotretinoin on three different human bladder cell lines in vitro. Urol Res 1999; 27: 17-22
  • 21 Levine N, Moon TE, Cartmel B et al. Trial of retinol and isotretinoin in skin cancer prevention: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group Cancer Epidemiol Biomarkers Prev 1997; 6: 957-961
  • 22 Lippmann SM, Davies PJ. Retinoids, neoplasia and differntiation therapy. Cancer Chemother Biol Response Modif 1997; 17: 349-362
  • 23 Lotan R. Effects of Vitamin A and its analogs (retionids) on normal and neoplastic cells. Biochim Biophys Acta 1980; 605: 33-91
  • 24 Meyskens FL, Kopecky KJ, Appelbaum FR. Effects of vitamin A on survival in patients with chronic myelogenous leukemia. Leuk Res 1995; 19: 605-612
  • 25 Miller WH Jr. The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer. Cancer 1998; 1471-1482
  • 26 Mongan NP, Gudas LJ. Diverse actions of retinoid receptors in cancer prevention and treatment. Differentiation 2007; 75: 853-870
  • 27 Moon TE, Levine N, Cartmel B et al. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group Cancer Epidemiol Biomarkers Prev 1997; 6: 949-56
  • 28 Motzer RJ, Murhy BA, Bacik J et al. Phase III trial of interferon alfa-2a with or without 13-cis retinoic acid for patients with advanced renal cell carcinoma. J Clin Oncol 2000; 18: 2972-2980
  • 29 Omenn GS, Goodman GE, Thornquist MD et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 1996; 334: 1150-1155
  • 30 De Pa, Veronesi U, Marubini E et al. Controlled clinical trials with fenretinide in breast cancer, basal cell carcinoma and oral leukoplakia. Journal of Cellular Biochemistry 1995; 59: 11-17
  • 31 Pastorino U, Infante M, Maioli M. Adjuvant treatment of stage I lung cancer with high-dose vitamin A. J Clin Oncol 1993; 1216-1222
  • 32 Plewig G, Kligman AM. Vitamin A (Retinol). Akne und Rosazea. Heidelberg: Springer; 1994
  • 33 Pouchieu C, Galan P, Ducros V et al. Plasma carotenoids and retinol and overall and breast cancer risk: a nested case-control study. Nutrition and cancer 2014; 66: 980-988
  • 34 Rutz HP, Little JB. Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid. International Journal of Radiation Oncology Biology Physics 1989; 16: 1285-1288
  • 35 Scheef W. Krebstherapie mit Vitamin A. In: Wrba H, (Hrsg.) Kombinierte Tumortherapie-Grundlagen, Möglichkeiten und Grenzen adjuvanter Methoden. Stuttgart: Hippokrates; 1995
  • 36 Seifter E, Rettura G, Padawer J et al. Vitamin A and beta-carotene as adjunctive therapy to tumor excision, radiation therapy, and chemotherapy. Prasad KN, (Hrsg.) Vitamins, Nutrition, and Cancer. International Symposium on Vitamins, Nutrition, and Cancer June 1983 Basel: Karger; 1984
  • 37 Smith MA, Parkinson DR, Cheson BD, Friedman MA. Retinoids in cancer therapy. J Clin Oncol 1992; 10: 839-864
  • 38 Snow GB, de Vries N. Zweittumoren bei Patienten mit Plattenepithelkarzinomen im Kopf-Hals-Bereich. Krebsrisiken im Kopf-Hals-Bereich 2013; 18-5
  • 39 Sommer A. Vitamin A. Its effect on childhood sight and life. Nutrition Reviews Washington 1994; 52: 60
  • 40 Struck R, Issing WJ. Einsatz von Retinolpalmitat bei Larynxleukoplakien. Sitzungsbericht Heidelberg: Springer; 1994
  • 41 Vainio H, Rautalahti M. An international evaluation of the cancer preventive potential of vitamin A. Cancer Epidemiology Biomarkers and Prevention 1999; 8: 107-109
  • 42 Veronesi U, De Palo G, Marubini E et al. Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. Journal of the National Cancer Institute 1999; 91: 1847-1856
  • 43 Warrell RP Jr., Frankel SR, Miller WH et al. Differentiation therapy of acute promyelotic leukemia with tretinoin (all-trans-retionoic acid). N Engl J Med 1991; 324: 1385-1393
  • 44 van Zandwijk N, Dalesio O, Pastorino U et al. EUROSCAN, a randomized Trial of Vitamin A and N-Acetylcysteine in patient with head and neck cancer or lung cancer. Journal of the National Cancer Institut 2000; 92: 977-986
  • 45 Zaridze D, Evstifeeva T, Boyle P. Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. Annals of epidemiology 1993; 3: 225-234