Pharmacopsychiatry 2017; 50(01): 5-13
DOI: 10.1055/s-0042-109400
Review
© Georg Thieme Verlag KG Stuttgart · New York

Oxytocin and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yoon Phaik Ooi
1   Clinical Psychology and Psychotherapy, Department of Psychology University of Basel, Switzerland
2   Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore
,
Shih-Jen Weng
2   Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore
3   Clinical Sciences, DUKE-NUS Medical School
,
Joe Kossowsky
1   Clinical Psychology and Psychotherapy, Department of Psychology University of Basel, Switzerland
4   Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, USA
5   Computational Health Informatics Program, Boston Children’s Hospital, Harvard Medical School, USA
,
Heike Gerger
1   Clinical Psychology and Psychotherapy, Department of Psychology University of Basel, Switzerland
,
Min Sung
2   Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore
› Author Affiliations
Further Information

Publication History

received 17 February 2016
revised 11 May 2016

accepted 12 May 2016

Publication Date:
30 August 2016 (online)

Abstract

Aim: Oxytocin presents an exciting potential to target the core symptoms of autism spectrum disorder (ASD) pharmacologically in an easily administered, cost-effective form with possibly minimal adverse effects. But, there are still major gaps in this area of research. This paper reviewed randomized controlled trials (RCTs) examining the effects of oxytocin administration on social cognition and restricted, repetitive behaviors in individuals with an ASD.

Method: Electronic literature searches were conducted from PsycINFO, PubMed, Web of Knowledge, and EMBASE for RCTs published through June 2015.

Results: 12 RCTs were included in this review. 7 out of the 11 studies that examined social cognition reported improvements. Additionally, one out of the 4 studies on restricted, repetitive behaviors, reported improvements following oxytocin administration. However, results from our meta-analyses suggest that oxytocin has no significant effect on these 2 domains.

Conclusion: Previous evidence revealed mixed findings about the effects of oxytocin on ASD. Given the limited number of RCTs, our summary of findings on the effectiveness of oxytocin on ASD should still be considered tentative.

 
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