Effects of Resistance Band Exercise on Vascular Activity and Fitness in Older Adults

Abstract

This study investigated the effects of a low to moderately intense resistance-band exercise intervention on cutaneous microvascular function in an older population. 18 sedentary healthy participants (age: 58±5) were assessed for their upper and lower-limb endothelial cutaneous vascular conductance using laser Doppler fluximetry with endothelial-dependent (80 μl acetylcholine chloride), and -independent vasodilation (80 μl sodium nitroprusside). In addition, participants underwent a range of functional assessments (cardiopulmonary fitness, strength, flexibility), and completed a perceived quality of life questionnaire. Participants were randomised into 2 groups: Exercise (EX) and Control (CON), and followed either an 8-week self-supervised home-based resistance-band intervention or maintained their habitual lifestyle. Following post-intervention assessment (n=16; EX=7, CON=9), EX improved acetylcholine-chloride-mediated endothelial-dependent vasodilation within the lower limb (cutaneous vascular conductance at 2 000 μCb; P<0.01), but without associated changes in the upper limb. Exercise, compared to CON, significantly affected sodium-nitroprusside-mediated independent vasodilation in the upper limb (P<0.01) at 2 000 μCb, but without associated changes in the lower limb. Of functional assessments, only lower limb strength and flexibility improved for EX (P<0.05). EX experienced positive changes within global measures of General Health, Bodily Pain and Energy/Fatigue (P<0.05). An 8-week home-based resistance-band exercise programme improves age-provoked microcirculatory endothelial vasodilation, but without concomitant changes in cardiopulmonary and anthropometric measures.

Key words

microcirculation - fitness assessment - resistance training - endothelium - ageing

• References

• 1 American College of Sports Medicine. Exercise and physical activity in older adults: Position statement. Med Sci Sports Exerc 2009; 41: 1510-1530
• 2 Armstrong MJ, Colberg SR, Sigal RJ. Moving beyond cardio: the value of resistance training, balance training, and other forms of exercise in the management of diabetes. Diabetes Spectr 2015; 28: 14-23
• 3 Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, Forman D, Franklin B, Guazzi M, Gulati M, Ketevian SJ, Lavie CJ, Macko R, Mancini D, Milani RV. Clinician's guide to cardiopulmonary exercise testing in adults: A scientific statement from the American Heart Association. Circulation 2010; 122: 191-225
• 4 Black MA, Green DJ, Cable NT. Exercise prevents age-related decline in nitricoxide-mediated vasodilator function in cutaneous microvessels. J Physiol 2008; 586: 3511-3524
• 5 Braith RW, Stewart KJ. Resistance exercise training its role in the prevention of cardiovascular disease. Circulation 2006; 113: 2642-2650
• 6 Capodaglio P, Capodaglio Edda M, Facioli M, Saibene F. Long-term strength training for community-dwelling people over 75: Impact on muscle function, functional ability and lifestyle. Eur J Appl Physiol 2006; 100: 535-542
• 7 Casey DP, Beck DT, Braith RW. Progressive resistance training without volume increases does not alter arterial stiffness and aortic wave reflection. Exp Biol Med 2007; 232: 1228-1235
• 8 Cheung YF, Chan GC, Ha SY. Arterial stiffness and endothelial function in patients with β-thalassemia major. Circulation 2002; 106: 2561-2566
• 9 Colado JC, Garcia-Masso X, Triplett TN, Flandez J, Borreani S, Tella V. Concurrent validation of the OMNI-resistance exercise scale of perceived exertion with thera-band resistance bands. J Strength Cond Res 2012; 26: 3018-3024
• 10 Colado JC, Triplett NT. Effects of a short-term resistance program using elastic bands versus weight machines for sedentary middle-aged women. J Strength Cond Res 2008; 22: 1441-1448
• 11 Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation 2007; 115: 1285-1295
• 12 Di Francescomarino S, Sciartilli A, Di Valerio V, Di Baldassarre A, Gallina S. The effect of physical exercise on endothelial function. Sports Med 2009; 39: 797-812
• 13 Dod HS, Bhardwaj R, Sajja V. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis. Am J Cardiol 2010; 105: 362-367
• 14 DuttaRoy S, Nilsson J, Hammarsten O. High frequency home-based exercise decreases levels of vascular endothelial growth factor in patients with stable angina pectoris. Eur J Prev Cardiol 2015; 22: 575-581
• 15 Ekkekakis P, Parfitt G, Petruzzello SJ. The pleasure and displeasure people feel when they exercise at different intensities: decennial update and progress towards a tripartite rationale for exercise intensity prescription. Sports Med 2011; 41: 641-671
• 16 Elsangedy HM, Krause MP, Krinski K, Alves RC, Chao CHN, DA Silva SG. Is the self-selected resistance exercise intensity by older women consistent with the American College of Sports Medicine guidelines to improve muscular fitness. J Strength Cond Res 2013; 27: 1877-1884
• 17 Eston R, Reilly T. (eds.). Kinanthropometry and Exercise Physiology Laboratory Manual: Anthropometry. Vol 1: third ed. Routledge; Abingdon, UK: 2009
• 18 Gates PE, Strain WD, Shore AC. Human endothelial function and microvascular ageing. Exp Physiol 2009; 94: 311-316
• 19 Hall EA, Docherty CL. The effectiveness of strength training protocols on strength development in participants with chronic ankle instability: a critically appraised topic. Int J Athl Ther Train 2015; 20: 13-17
• 20 Harriss DJ, Atkinson G. Ethical standards in sports and exercise science research: 2016 update. Int J Sports Med 2015; 36: 1121-1124
• 21 Hays RD, Morales LS. The RAND-36 measure of health-related quality of life. Ann Med 2001; 33: 350-357
• 22 Holowatz LA, Thompson-Torgerson CS, Kenney WL. Altered mechanisms of vasodilation in aged human skin. Exerc Sport Sci Rev 2007; 35: 119-125
• 23 Hopkins WG. Measures of reliability in sports medicine and science. Sports Med 2000; 30: 1-15
• 24 Hunter GR, McCarthy JP, Bamman MM. Effects of resistance training on older adults. Sports Med 2004; 34: 329-348
• 25 Kamm CP, Mattle HP, Müri RM. Home-based training to improve manual dexterity in patients with multiple sclerosis: A randomized controlled trial. Mult Scler 2015; 21: 1546-56
• 26 Kawano H, Tanaka H, Miyachi M. Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening. J Hypertens 2006; 24: 1753-1759
• 27 King AC, Rejeski WJ, Buchner DM. Physical activity interventions targeting older adults: a critical review and recommendations. Am J Prev Med 1998; 15: 316-333
• 28 Klonizakis M, Alkhatib A, Middleton G, Smith MF. Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity. Clin Sci 2013; 124: 579-87
• 29 Klonizakis M, Lingam K, Manning G, Donnelly R. Characterising the time-course of microvascular vasodilator responses in humans using laser Doppler fluximetry and iontophoresis. J Pharmacol Toxicol Methods 2011; 63: 115-118
• 30 Klonizakis M, Tew G, Michaels J, Saxton J. Impaired microvascular endothelial function is restored by acute lower limb exercise in post-surgical varicose vein patients. Microvasc Res 2009; 77: 158-162
• 31 Klonizakis M, Tew G, Michaels J, Saxton J. Exercise training improves cutaneous microvascular endothelial function in post-surgical varicose vein patients. Microvasc Res 2009; 78: 67-70
• 32 MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR. Arterial blood pressure response to heavy resistance exercise. J Appl Physiol 1985; 58: 785-790
• 33 Maeda S, Otsuki T, Iemitsu M, Kamioka M, Sugawara J, Kuno S, Tanaka H. Effects of leg resistance training on arterial function in older men. Br J Sports Med 2006; 40: 867-869
• 34 Mikkelsen LR, Mechlenburg I, Søballe K, Jørgensen LB, Mikkelsen S, Bandholm T, Petersen AK. Effect of early supervised progressive resistance training compared to unsupervised home-based exercise after fast-track total hip replacement applied to patients with preoperative functional limitations. A single-blinded randomised controlled trial. Osteoarthritis Cartilage 2014; 22: 2051-2058
• 35 Miyachi M. Effects of resistance training on arterial stiffness: a meta-analysis. Br J Sports Med 2013; 47: 393-396
• 36 Nakamura M, Sugawara S, Arakawa N. Reduced vascular compliance is associated with impaired endothelium-dependent dilatation in the brachial artery of patients with congestive heart failure. J Card Fail 2004; 10: 36-42
• 37 Padilla J, Simmons GH, Bender SB, Arce-Esquivel AA, Whyte JJ, Laughlin MH. Vascular effects of exercise: endothelial adaptations beyond active muscle beds. Physiology (Bethesda) 2011; 26: 132-145
• 38 Patterson RM, Stegink Jansen CW, Hogan HA, Nassif MD. Material properties of thera-band tubing. Phys Ther 2001; 81: 1437-1445
• 39 Ramos EM, de Toledo-Arruda AC, Fosco LC. The effects of elastic tubing-based resistance training compared with conventional resistance training in patients with moderate chronic obstructive pulmonary disease: a randomized clinical trial. Clin Rehabil 2014; 28: 1096-1106
• 40 Tew GA, Klonizakis M, Saxton JM. Effects of ageing and fitness on skin microvessel vasodilator function in humans. Eur J Appl Physiol 2010; 109: 173-181
• 41 Tew GA, Saxton JM, Klonizakis M, Moss J, Ruddock AD, Hodges GJ. Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. J Appl Physiol 2011; 110: 1264-1270
• 42 Umpierre D, Stein R. Hemodynamic and vascular effects of resistance training: implications for cardiovascular disease. Arq Bras Cardiol 2007; 89: 256-262
• 43 Wasserman K. The anaerobic threshold: definition, physiological significance and identification. Adv Cardiol 1986; 35: 1-23