Int J Sports Med 2017; 38(04): 307-313
DOI: 10.1055/s-0042-123192
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Resistance Training Volume on MMPs in Circulation, Muscle and Adipose Tissue

Ivo Vieira de Sousa Neto
1   Graduate program of Physical Education, Catholic University of Brasilia, Distrito Federal, Brazil
,
Ramires Alsamir Tibana
1   Graduate program of Physical Education, Catholic University of Brasilia, Distrito Federal, Brazil
,
Dahan da Cunha Nascimento
1   Graduate program of Physical Education, Catholic University of Brasilia, Distrito Federal, Brazil
2   School of Health, UDF University Center, Distrito Federal, Brazil
,
Denis César Leite Vieira
1   Graduate program of Physical Education, Catholic University of Brasilia, Distrito Federal, Brazil
2   School of Health, UDF University Center, Distrito Federal, Brazil
,
Joao Luiz Quagliotti Durigan
3   Graduate program of Rehabilitation Sciences and Technology of Health, University of Brasilia, Distrito Federal, Brazil
,
Guilherme Borges Pereira
1   Graduate program of Physical Education, Catholic University of Brasilia, Distrito Federal, Brazil
,
James Wilfred Navalta
4   Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, United States of America
,
Rita de Cássia Marqueti
3   Graduate program of Rehabilitation Sciences and Technology of Health, University of Brasilia, Distrito Federal, Brazil
,
Jonato Prestes
1   Graduate program of Physical Education, Catholic University of Brasilia, Distrito Federal, Brazil
› Author Affiliations
Further Information

Publication History



accepted after revision 27 November 2016

Publication Date:
20 February 2017 (online)

Abstract

The aim of this study was to investigate the effects of different resistance training (RT) volumes on MMP activity in skeletal muscle, visceral adipose tissue and circulation. 21 Wistar rats were randomly divided into 3 groups (n=7 per group): sedentary control (SC); RT with 4 ladder climbs (RT-4; 50, 75, 90 and 100% of their maximal carrying capacity) and RT with 8 ladder climbs (RT-8 with 2 sets for each load). The 8-week RT consisted of climbing a 1.1-m vertical ladder with weights secured to the animals’ tails. MMP-2 and -9 activity were analyzed by zymography. RT-8 displayed higher active MMP-2 activity as compared with SC and RT-4 in skeletal muscle (p<0.05). There was no significant difference between groups for pro and intermediate-MMP-2 activity in visceral adipose tissue, while RT-8 presented lower active MMP-2 activity as compared with SC (p<0.05). Plasma pro and active MMP-2 and MMP-9 activity was lower in RT-8 as compared with RT-4 (p<0.05). These results suggest that higher volume RT up-regulates MMP-2 activity in skeletal muscle, while down-regulating MMP-2 in visceral adipose tissue. Moreover, it induces a decrease of MMP-2, 9 activity in circulation. Different tissue and circulatory MMP responses to RT may result in specific remodeling.

 
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