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Clin Colon Rectal Surg 2022; 35(04): 316-320
DOI: 10.1055/s-0042-1743589
Review Article

Role of the Mesentery in Crohn's Terminal Ileitis

Authors

  • Marte A.J. Becker

    1   Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology & Metabolism, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

  • Eline M.L. van der Does de Willebois

    2   Department of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands

  • Willem A. Bemelman

    2   Department of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands

  • Manon E. Wildenberg

    1   Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology & Metabolism, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

  • Christianne J. Buskens

    2   Department of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands
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Abstract

Despite the longstanding awareness of the presence of mesenteric alterations in Crohn's disease, the functional and clinical consequences of these alterations remain a topic of debate. Guidelines advise a limited resection without resection of the adjacent mesentery to prevent short bowel syndrome and postoperative complications. However, recently mesenteric resection has been proposed as an alternative to reduce recurrence rates in Crohn's disease patients. Here, we evaluate the data available on this topic in terminal ileitis, both from a fundamental research point of view and clinical perspective.

Keywords

Crohn's disease - mesentery - macrophages - ileocecal resection


Publication History

Article published online:
04 July 2022

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