Semin Respir Crit Care Med 2022; 43(05): 675-683
DOI: 10.1055/s-0042-1749636
Review Article

Improving Medication Adherence in Asthma

Patrick J. Kerr
1   Clinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
2   Department of Medicine, Bons Secours Hospital, Glasnevin, Dublin, Ireland
,
Vincent Brennan
1   Clinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
,
Elaine Mac Hale
1   Clinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
,
Frank Doyle
3   Department of Health Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
,
Richard W. Costello
1   Clinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
4   Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland
› Author Affiliations

Abstract

In little over a generation, the ingenuity of scientists and clinician researchers has developed inhaled medications and pathway-specific biological agents that control the inflammation and physiology of asthma. Unfortunately, whether it is because of cost or difficulty understanding why or how to use inhaled medications, patients often do not take these medications. The consequences of poor treatment adherence, loss of control and exacerbations, are the same as if the condition remained untreated. Furthermore, poor adherence is difficult to detect without direct measurement. Together this means that poor treatment adherence is easily overlooked and, instead of addressing the cause of poor adherence, additional medicines may be prescribed. In other words, poor treatment adherence is a risk for the patient and adds cost to healthcare systems. In this article, we discuss the rationale for and the delivery of successful interventions to improve medication adherence in asthma. We contextualize these interventions by describing the causes of poor treatment adherence and how adherence is assessed. Finally, future perspectives on the design of new interventions are described.



Publication History

Article published online:
07 June 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Crompton G. A brief history of inhaled asthma therapy over the last fifty years. Prim Care Respir J 2006; 15 (06) 326-331
  • 2 Spitzer WO, Suissa S, Ernst P. et al. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med 1992; 326 (08) 501-506
  • 3 Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 2006; 144 (12) 904-912
  • 4 Cates CJ, Cates MJ. Regular treatment with formoterol for chronic asthma: serious adverse events. Cochrane Database Syst Rev 2012; 4 (04) CD006923
  • 5 Pennington E, Yaqoob ZJ, Al-Kindi SG, Zein J. Trends in asthma mortality in the United States: 1999 to 2015. Am J Respir Crit Care Med 2019; 199 (12) 1575-1577
  • 6 Sabaté E. ed. Adherence to Long-Term Therapies: Evidence for Action. Geneva: World Health Organization; 2003
  • 7 Bidwal M, Lor K, Yu J, Ip E. Evaluation of asthma medication adherence rates and strategies to improve adherence in the underserved population at a federally qualified health center. Res Social Adm Pharm 2017; 13 (04) 759-766
  • 8 Rand CS, Wise RA. Measuring adherence to asthma medication regimens. Am J Respir Crit Care Med 1994;149(2, Pt 2):S69–S76, discussion S77–S78
  • 9 Foster JM, Usherwood T, Smith L. et al. Inhaler reminders improve adherence with controller treatment in primary care patients with asthma. J Allergy Clin Immunol 2014; 134 (06) 1260-1268.e3
  • 10 Chung KF, Wenzel SE, Brozek JL. et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43 (02) 343-373
  • 11 Vrijens B, De Geest S, Hughes DA. et al; ABC Project Team. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol 2012; 73 (05) 691-705
  • 12 Wu AC, Butler MG, Li L. et al. Primary adherence to controller medications for asthma is poor. Ann Am Thorac Soc 2015; 12 (02) 161-166
  • 13 Kardas G, Panek M, Kuna P, Kardas P. Primary non-adherence to inhaled medications measured with e-prescription data from Poland. Clin Transl Allergy 2020; 10 (01) 39
  • 14 Breekveldt-Postma NS, Koerselman J, Erkens JA, van der Molen T, Lammers JW, Herings RM. CAMERA Study Group Members Listed in the Appendix. Treatment with inhaled corticosteroids in asthma is too often discontinued. Pharmacoepidemiol Drug Saf 2008; 17 (04) 411-422
  • 15 van Boven JFM, Koponen M, Lalic S. et al. Trajectory analyses of adherence patterns in a real-life moderate to severe asthma population. J Allergy Clin Immunol Pract 2020; 8 (06) 1961-1969.e6
  • 16 Baumgartner PC, Haynes RB, Hersberger KE, Arnet I. A systematic review of medication adherence thresholds dependent of clinical outcomes. Front Pharmacol 2018; 9: 1290-1290
  • 17 Williams LK, Peterson EL, Wells K. et al. Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence. J Allergy Clin Immunol 2011; 128 (06) 1185-1191.e2
  • 18 Hassan M, Davies SE, Trethewey SP, Mansur AH. Prevalence and predictors of adherence to controller therapy in adult patients with severe/difficult-to-treat asthma: a systematic review and meta-analysis. J Asthma 2020; 57 (12) 1379-1388
  • 19 Murphy J, McSharry J, Hynes L, Matthews S, Van Rhoon L, Molloy GJ. Prevalence and predictors of adherence to inhaled corticosteroids in young adults (15-30 years) with asthma: a systematic review and meta-analysis. J Asthma 2021; 58 (05) 683-705
  • 20 Busse PJ, McDonald VM, Wisnivesky JP, Gibson PG. Asthma across the ages: adults. J Allergy Clin Immunol Pract 2020; 8 (06) 1828-1838
  • 21 Ismaila A, Corriveau D, Vaillancourt J. et al. Impact of adherence to treatment with fluticasone propionate/salmeterol in asthma patients. Curr Med Res Opin 2014; 30 (07) 1417-1425
  • 22 Engelkes M, Janssens HM, de Jongste JC, Sturkenboom MCJM, Verhamme KMC. Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur Respir J 2015; 45 (02) 396-407
  • 23 Chongmelaxme B, Chaiyakunapruk N, Dilokthornsakul P. Association between adherence and severe asthma exacerbation: a systematic review and meta-analysis. J Am Pharm Assoc (2003) 2020; 60 (05) 669-685.e2
  • 24 RCP London. Why Asthma Still Kills: The National Review of Asthma Deaths (NRAD) Confidential Enquiry Report. London: RCP; 2014 . Accessed March 31, 2022 at: https://www.rcplondon.ac.uk/projects/outputs/why-asthma-still-kills
  • 25 Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma. Bull World Health Organ 2005; 83 (07) 548-554
  • 26 Zafari Z, Lynd LD, FitzGerald JM, Sadatsafavi M. Economic and health effect of full adherence to controller therapy in adults with uncontrolled asthma: a simulation study. J Allergy Clin Immunol 2014; 134 (04) 908-915.e3
  • 27 Dima AL, Hernandez G, Cunillera O, Ferrer M, de Bruin M. ASTRO-LAB group. Asthma inhaler adherence determinants in adults: systematic review of observational data. Eur Respir J 2015; 45 (04) 994-1018
  • 28 Monteiro C, Maricoto T, Prazeres F, Augusto Simões P, Augusto Simões J. Determining factors associated with inhaled therapy adherence on asthma and COPD: a systematic review and meta-analysis of the global literature. Respir Med 2022; 191: 106724
  • 29 Mazumdar S, Ghosh S, Mukherjee S. Non-adherence to asthma medications: Relation to socio-economic status and asthma education. Eur Respir J 2015; 46 (Suppl 59): OA4792
  • 30 Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57 (03) 226-230
  • 31 Hiscock R, Bauld L, Amos A, Fidler JA, Munafò M. Socioeconomic status and smoking: a review. Ann N Y Acad Sci 2012; 1248: 107-123
  • 32 Schyllert C, Lindberg A, Hedman L. et al. Low socioeconomic status relates to asthma and wheeze, especially in women. ERJ Open Res 2020; 6 (03) 00258-02019
  • 33 Laba T-L, Jan S, Zwar NA. et al. Cost-related underuse of medicines for asthma-opportunities for improving adherence. J Allergy Clin Immunol Pract 2019; 7 (07) 2298-2306.e12
  • 34 Baker R, Freeman GK, Haggerty JL, Bankart MJ, Nockels KH. Primary medical care continuity and patient mortality: a systematic review. Br J Gen Pract 2020; 70 (698): e600-e611
  • 35 Cloutier MM, Salo PM, Akinbami LJ. et al. Clinician agreement, self-efficacy, and adherence with the guidelines for the diagnosis and management of asthma. J Allergy Clin Immunol Pract 2018; 6 (03) 886-894.e4
  • 36 Wilson SR, Strub P, Buist AS. et al; Better Outcomes of Asthma Treatment (BOAT) Study Group. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am J Respir Crit Care Med 2010; 181 (06) 566-577
  • 37 Busby J, Matthews JG, Chaudhuri R. et al; Investigators for the MRC Refractory Asthma Stratification Program. Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma. Eur Respir J 2021; 2100768: 2100768
  • 38 Mulvey C, MacHale E, Greene G. et al. Patient-selected treatment goals in severe asthma. J Allergy Clin Immunol Pract 2021; 9 (07) 2732-2741.e1
  • 39 Roy A, Battle K, Lurslurchachai L, Halm EA, Wisnivesky JP. Inhaler device, administration technique, and adherence to inhaled corticosteroids in patients with asthma. Prim Care Respir J 2011; 20 (02) 148-154
  • 40 Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med 2008; 31 (03) 213-224
  • 41 Sulaiman I, Seheult J, MacHale E. et al. A method to calculate adherence to inhaled therapy that reflects the changes in clinical features of asthma. Ann Am Thorac Soc 2016; 13 (11) 1894-1903
  • 42 Holmes MS, Seheult JN, Geraghty C. et al. A method of estimating inspiratory flow rate and volume from an inhaler using acoustic measurements. Physiol Meas 2013; 34 (08) 903-914
  • 43 Seheult JN, Costello S, Tee KC. et al. Investigating the relationship between peak inspiratory flow rate and volume of inhalation from a Diskus™ Inhaler and baseline spirometric parameters: a cross-sectional study. Springerplus 2014; 3 (01) 496
  • 44 Bosnic-Anticevich S, Chrystyn H, Costello RW. et al. The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes. Int J Chron Obstruct Pulmon Dis 2016; 12: 59-71
  • 45 Cole S, Seale C, Griffiths C. ‘The blue one takes a battering’ why do young adults with asthma overuse bronchodilator inhalers? A qualitative study. BMJ Open 2013; 3 (02) e002247
  • 46 Chapman KR, Barnes NC, Greening AP, Jones PW, Pedersen S. Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal. Thorax 2010; 65 (08) 747-752
  • 47 Fleming DM, Cross KW, Sunderland R, Ross AM. Comparison of the seasonal patterns of asthma identified in general practitioner episodes, hospital admissions, and deaths. Thorax 2000; 55 (08) 662-665
  • 48 Turi KN, Gebretsadik T, Lee RL. et al. Seasonal patterns of asthma medication fills among diverse populations of the United States. J Asthma 2018; 55 (07) 764-770
  • 49 Sangeda RZ, Mosha F, Prosperi M. et al. Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings. BMC Public Health 2014; 14 (01) 1035
  • 50 Galozy A, Nowaczyk S. Prediction and pattern analysis of medication refill adherence through electronic health records and dispensation data. J Biomed Inform 2020; 112S: 100075
  • 51 Andrade SE, Kahler KH, Frech F, Chan KA. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf 2006; 15 (08) 565-574 , discussion 575–577
  • 52 Plaza V, Giner J, Curto E. et al; Investigators of the RE-TAI Study. Assessing adherence by combining the test of adherence to inhalers with pharmacy refill records. J Investig Allergol Clin Immunol 2021; 31 (01) 58-64
  • 53 Chan AHY, Pleasants RA, Dhand R. et al. Digital inhalers for asthma or chronic obstructive pulmonary disease: a scientific perspective. Pulm Ther 2021; 7 (02) 345-376
  • 54 Greene G, Costello RW, Cushen B. et al. A novel statistical method for assessing effective adherence to medication and calculating optimal drug dosages. PLoS One 2018; 13 (04) e0195663
  • 55 Patel MR, Press VG, Gerald LB. et al. Improving the affordability of prescription medications for people with chronic respiratory disease: an official American Thoracic Society Policy Statement. Am J Respir Crit Care Med 2018; 198 (11) 1367-1374
  • 56 Lin NY, Ramsey RR, Miller JL. et al. Telehealth delivery of adherence and medication management system improves outcomes in inner-city children with asthma. Pediatr Pulmonol 2020; 55 (04) 858-865
  • 57 Clatworthy J, Price D, Ryan D, Haughney J, Horne R. The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control. Prim Care Respir J 2009; 18 (04) 300-305
  • 58 Menckeberg TT, Bouvy ML, Bracke M. et al. Beliefs about medicines predict refill adherence to inhaled corticosteroids. J Psychosom Res 2008; 64 (01) 47-54
  • 59 Wroe AL. Intentional and unintentional nonadherence: a study of decision making. J Behav Med 2002; 25 (04) 355-372
  • 60 Klijn SL, Hiligsmann M, Evers SMAA, Román-Rodríguez M, van der Molen T, van Boven JFM. Effectiveness and success factors of educational inhaler technique interventions in asthma & COPD patients: a systematic review. NPJ Prim Care Respir Med 2017; 27 (01) 24
  • 61 Kocks JWH, Chrystyn H, van der Palen J. et al. Systematic review of association between critical errors in inhalation and health outcomes in asthma and COPD. NPJ Prim Care Respir Med 2018; 28 (01) 43
  • 62 Normansell R, Kew KM, Stovold E. Interventions to improve adherence to inhaled steroids for asthma. Cochrane Database Syst Rev 2017; 4 (04) CD012226
  • 63 Stirratt MJ, Dunbar-Jacob J, Crane HM. et al. Self-report measures of medication adherence behavior: recommendations on optimal use. Transl Behav Med 2015; 5 (04) 470-482
  • 64 Bruzzese JM, Sheares BJ, Vincent EJ. et al. Effects of a school-based intervention for urban adolescents with asthma: a controlled trial. Am J Respir Crit Care Med 2011; 183 (08) 998-1006
  • 65 Castro M, Zimmermann NA, Crocker S, Bradley J, Leven C, Schechtman KB. Asthma intervention program prevents readmissions in high healthcare users. Am J Respir Crit Care Med 2003; 168 (09) 1095-1099
  • 66 Sheares BJ, Mellins RB, Dimango E. et al. Do patients of subspecialist physicians benefit from written asthma action plans?. Am J Respir Crit Care Med 2015; 191 (12) 1374-1383
  • 67 Newman TV, San-Juan-Rodriguez A, Parekh N. et al. Impact of community pharmacist-led interventions in chronic disease management on clinical, utilization, and economic outcomes: an umbrella review. Res Social Adm Pharm 2020; 16 (09) 1155-1165
  • 68 Garcia-Cardenas V, Armour C, Benrimoj SI, Martinez-Martinez F, Rotta I, Fernandez-Llimos F. Pharmacists' interventions on clinical asthma outcomes: a systematic review. Eur Respir J 2016; 47 (04) 1134-1143
  • 69 Armour C, Bosnic-Anticevich S, Brillant M. et al. Pharmacy Asthma Care Program (PACP) improves outcomes for patients in the community. Thorax 2007; 62 (06) 496-502
  • 70 Amorha KC, Okonta MJ, Ukwe CV. Impact of pharmacist-led educational interventions on asthma control and adherence: single-blind, randomised clinical trial. Int J Clin Pharm 2021; 43 (03) 689-697
  • 71 Ferrante G, La Grutta S. The burden of pediatric asthma. Front Pediatr 2018; 6 (186): 186
  • 72 Halterman JS, Fagnano M, Tajon RS. et al. Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) program on asthma morbidity: a randomized clinical trial. JAMA Pediatr 2018; 172 (03) e174938
  • 73 Hanghøj S, Boisen KA. Self-reported barriers to medication adherence among chronically ill adolescents: a systematic review. J Adolesc Health 2014; 54 (02) 121-138
  • 74 Bolman C, Arwert TG, Völlink T. Adherence to prophylactic asthma medication: habit strength and cognitions. Heart Lung 2011; 40 (01) 63-75
  • 75 Sulaiman I, Greene G, MacHale E. et al. A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma. Eur Respir J 2018; 51 (01) 1701126
  • 76 O'Dwyer S, Greene G, MacHale E. et al. Personalized biofeedback on inhaler adherence and technique by community pharmacists: a cluster randomized clinical trial. J Allergy Clin Immunol Pract 2020; 8 (02) 635-644
  • 77 Dong J, Reeves L, Ali A, Freeman MK, Adunlin G. A systematic review of the effectiveness of text message reminders on asthma medication adherence. Innov Pharm 2018; 9 (03) 1-7
  • 78 Tran N, Coffman JM, Sumino K, Cabana MD. Patient reminder systems and asthma medication adherence: a systematic review. J Asthma 2014; 51 (05) 536-543
  • 79 Charles T, Quinn D, Weatherall M, Aldington S, Beasley R, Holt S. An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma. J Allergy Clin Immunol 2007; 119 (04) 811-816
  • 80 Chan AH, Stewart AW, Harrison J, Camargo Jr CA, Black PN, Mitchell EA. The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial. Lancet Respir Med 2015; 3 (03) 210-219
  • 81 Gregoriano C, Dieterle T, Breitenstein AL. et al. Does a tailored intervention to promote adherence in patients with chronic lung disease affect exacerbations? A randomized controlled trial. Respir Res 2019; 20 (01) 273
  • 82 Price D, Robertson A, Bullen K, Rand C, Horne R, Staudinger H. Improved adherence with once-daily versus twice-daily dosing of mometasone furoate administered via a dry powder inhaler: a randomized open-label study. BMC Pulm Med 2010; 10 (01) 1
  • 83 Averell CM, Stanford RH, Laliberté F, Wu JW, Germain G, Duh MS. Medication adherence in patients with asthma using once-daily versus twice-daily ICS/LABAs. J Asthma 2021; 58 (01) 102-111
  • 84 Cusack RP, Satia I, O'Byrne PM. Asthma maintenance and reliever therapy: Should this be the standard of care?. Ann Allergy Asthma Immunol 2020; 125 (02) 150-155
  • 85 O'Byrne PM, Bisgaard H, Godard PP. et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005; 171 (02) 129-136
  • 86 Jorup C, Lythgoe D, Bisgaard H. Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma. Eur Respir J 2018; 51 (01) 1701688
  • 87 Hendeles L, Blake KV, Galbreath A. A Single Inhaler Combining a Corticosteroid and Long-Acting Beta-2 Agonist for Maintenance with Additional Doses for Reliever Therapy (SMART): obstacles for asthma patients in the USA. Pediatr Allergy Immunol Pulmonol 2021; 34 (02) 73-75
  • 88 Reddel HK, Bacharier LB, Bateman ED. et al. Global initiative for asthma strategy 2021: executive summary and rationale for key changes. Eur Respir J 2021; 59 (01) 2102730
  • 89 Cerveri I, Locatelli F, Zoia MC, Corsico A, Accordini S, de Marco R. International variations in asthma treatment compliance: the results of the European Community Respiratory Health Survey (ECRHS). Eur Respir J 1999; 14 (02) 288-294
  • 90 Fan Q, Ong ASE, Koh MS, Doshi K. The mediating role of trust in physician and self-efficacy in understanding medication adherence in severe asthma. Respir Med 2021; 190: 106673
  • 91 Ludden T, Shade L, Reeves K. et al. Asthma dissemination around patient-centered treatments in North Carolina (ADAPT-NC): a cluster randomized control trial evaluating dissemination of an evidence-based shared decision-making intervention for asthma management. J Asthma 2019; 56 (10) 1087-1098
  • 92 Kew KM, Malik P, Aniruddhan K, Normansell R. Shared decision-making for people with asthma. Cochrane Database Syst Rev 2017; 10 (10) CD012330
  • 93 Hettema J, Steele J, Miller WR. Motivational interviewing. Annu Rev Clin Psychol 2005; 1 (01) 91-111
  • 94 Frost H, Campbell P, Maxwell M. et al. Effectiveness of motivational interviewing on adult behaviour change in health and social care settings: a systematic review of reviews. PLoS One 2018; 13 (10) e0204890
  • 95 Gesinde B, Harry S. The use of motivational interviewing in improving medication adherence for individuals with asthma: a systematic review. Perspect Public Health 2018; 138 (06) 329-335
  • 96 Wolever RQ, Simmons LA, Sforzo GA. et al. A systematic review of the literature on health and wellness coaching: defining a key behavioral intervention in healthcare. Glob Adv Health Med 2013; 2 (04) 38-57
  • 97 Crane MA, Jenkins CR, Goeman DP, Douglass JA. Inhaler device technique can be improved in older adults through tailored education: findings from a randomised controlled trial. NPJ Prim Care Respir Med 2014; 24 (01) 14034
  • 98 Garbutt JM, Yan Y, Highstein G, Strunk RC. A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity. J Allergy Clin Immunol 2015; 135 (05) 1163-70.e1 , 2
  • 99 Garbutt JM, Banister C, Highstein G. et al. Telephone coaching for parents of children with asthma: impact and lessons learned. Arch Pediatr Adolesc Med 2010; 164 (07) 625-630
  • 100 Federman AD, O'Conor R, Mindlis I. et al. Effect of a self-management support intervention on asthma outcomes in older adults: the SAMBA Study Randomized Clinical Trial. JAMA Intern Med 2019; 179 (08) 1113-1121
  • 101 MIMS Ireland. Monthly Index of Medical Specialities Ireland (MIMS Ireland) MIMS[online]. Dublin: MIMS Ireland; 2022. Accessed January 30, 2022 at: https://https://www.mims.ie/.
  • 102 Drug Price Information from Drugs.com c2000–2022. Accessed March 31, 2022 at: https://www.drugs.com/price-guide/