Neuropediatrics 2022; 53(04): 246-250
DOI: 10.1055/s-0042-1750736
Original Article

The Incidence of Intraventricular Hemorrhage in Low-Birth-Weight Infants: Assessment by Magnetic Resonance Imaging

1   Department of Diagnostic Radiology, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
,
Koichi Tanda
2   Department of Neonatology, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
3   Department of Pediatrics, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
,
1   Department of Diagnostic Radiology, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
,
Akira Nishimura
2   Department of Neonatology, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
,
Daisuke Kinoshita
2   Department of Neonatology, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
,
Yuko Sano
1   Department of Diagnostic Radiology, Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
› Author Affiliations
Funding None.

Abstract

Purpose Intraventricular hemorrhage (IVH) is common in infants with a low-birth-weight (LBW) and has been suggested to cause major impairment not only of future motor development but also of cognitive function and learning ability. The purpose of the present study is to assess the frequency of IVH using magnetic resonance imaging (MRI) in LBW infants and its clinical neurodevelopmental outcomes.

Methods We enrolled a consecutive series of 247 neonates with an LBW of < 1,500 g hospitalized in the newborn intensive care unit between 2010 and 2015. The presence of IVH was examined using T2* MRI at term-equivalent age (TEA). We then investigated the clinical outcome at ≥3 years of age and its correlation with the IVH grade.

Results The overall incidence of IVH among LBW infants was 16.2%. The proportion of infants with IVH showing a favorable outcome did not differ significantly from that of infants without IVH. The proportion of neonates showing a poor outcome was 6.7% for those with IVH and 1.9% for those without IVH and 2.7% for those with and without IVH combined.

Conclusion We were able to clarify the frequency of IVH in LBW infants using MRI at TEA. We demonstrated the lower incidence of mortality and IVH, the higher incidence of a favorable outcome, and the lower incidence of poor outcome.

Ethical Approval

This retrospective study was approved by the institutional ethics committees. Given the retrospective nature of this study and the use of anonymized data, the requirement for informed consent was waived.




Publication History

Received: 19 January 2022

Accepted: 05 May 2022

Article published online:
17 July 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Sheth RD. Trends in incidence and severity of intraventricular hemorrhage. J Child Neurol 1998; 13 (06) 261-264
  • 2 Stoll BJ, Hansen NI, Bell EF. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126 (03) 443-456
  • 3 Jain NJ, Kruse LK, Demissie K, Khandelwal M. Impact of mode of delivery on neonatal complications: trends between 1997 and 2005. J Matern Fetal Neonatal Med 2009; 22 (06) 491-500
  • 4 Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92 (04) 529-534
  • 5 Radic JA, Vincer M, McNeely PD. Outcomes of intraventricular hemorrhage and posthemorrhagic hydrocephalus in a population-based cohort of very preterm infants born to residents of Nova Scotia from 1993 to 2010. J Neurosurg Pediatr 2015; 15 (06) 580-588
  • 6 Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Lui K. New South Wales and Australian Capital Territory Neonatal Intensive Care Units' Data Collection. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics 2014; 133 (01) 55-62
  • 7 Nakanishi H, Suenaga H, Uchiyama A, Kono Y, Kusuda S. Neonatal Research Network, Japan. Trends in the neurodevelopmental outcomes among preterm infants from 2003-2012: a retrospective cohort study in Japan. J Perinatol 2018; 38 (07) 917-928
  • 8 Hirata K, Kimura T, Hirano S, Wada K, Kusuda S, Fujimura M. Neonatal Research Network of Japan. Outcomes of outborn very-low-birth-weight infants in Japan. Arch Dis Child Fetal Neonatal Ed 2021; 106 (02) 131-136
  • 9 Al-Abdi SY, Al-Aamri MA. A systemic review and meta-analysis of the timing of early intraventricular hemorrhage in preterm neonates: clinical and research implication. J Clin Neonatol 2014; 3 (02) 76-88
  • 10 Payne AH, Hintz SR, Hibbs AM. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA Pediatr 2013; 167 (05) 451-459
  • 11 Shah PS, Lui K, Sjörs G. et al; International Network for Evaluating Outcomes (iNeo) of Neonates. Neonatal outcomes of very low birth weight and very preterm neonates: an international comparison. J Pediatr 2016; 177: 144-152 .e6
  • 12 Lui K, Lee SK, Kusuda S. et al; International Network for Evaluation of Outcomes (iNeo) of neonates Investigators. Trends in outcomes for neonates born very preterm and very low birth weight in 11 high-income countries. J Pediatr 2019; 215: 32-40 .e14
  • 13 Mukerji A, Shah V, Shah PS. Periventricular/intraventricular hemorrhage and neurodevelopmental outcomes: a meta-analysis. Pediatrics 2015; 136 (06) 1132-1143
  • 14 Sheehan JW, Pritchard M, Heyne RJ. et al. Severe intraventricular hemorrhage and withdrawal of support in preterm infants. J Perinatol 2017; 37 (04) 441-447
  • 15 Maitre NL, Marshall DD, Price WA. et al. Neurodevelopmental outcome of infants with unilateral or bilateral periventricular hemorrhagic infarction. Pediatrics 2009; 124 (06) e1153-e1160
  • 16 van Buuren LM, van der Aa NE, Dekker HC. et al. Cognitive outcome in childhood after unilateral perinatal brain injury. Dev Med Child Neurol 2013; 55 (10) 934-940
  • 17 Brouwer A, Groenendaal F, van Haastert IL, Rademaker K, Hanlo P, de Vries L. Neurodevelopmental outcome of preterm infants with severe intraventricular hemorrhage and therapy for post-hemorrhagic ventricular dilatation. J Pediatr 2008; 152 (05) 648-654