Abstract
Migraine is a common neurologic disorder in children, especially in adolescents. It
can affect the school performance, family, and social daily activities. The Pediatric
Migraine Disability Assessment Scale (PedMIDAS) is commonly used in young patients.
This study evaluated vitamin B12 deficiency in children with migraine and the effect
of hydroxocobalamin treatment on PedMIDAS scores. The study group comprised patients
with vitamin B12 deficiency and diagnosed migraine. The PedMIDAS questionnaire was
conducted before and 3 months after hydroxocobalamin treatment. PedMIDAS scores were
evaluated and compared before and after hydroxocobalamin treatment. The mean ± standard
deviation of vitamin B12 level was 175.9 ± 21.3 pg/mL in children with migraine. The
PedMIDAS scores were significantly lower after hydroxocobalamin treatment than before
treatment (p < 0.001). These results indicated that hydroxocobalamin made a positive contribution
to the mitigation of migraine symptoms in children and that treating vitamin B12 deficiency
could be a useful option.
Keywords
childhood migraine - PedMIDAS - vitamin B12
