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Exp Clin Endocrinol Diabetes 2017; 125(07): 470-477
DOI: 10.1055/s-0043-107783
Article
© Georg Thieme Verlag KG Stuttgart · New York

Total Serum Antioxidant Capacity in Healthy Normal Weight and Asymptomatic Overweight Adults

Ana Petelin
1   Faculty of Health Sciences, University of Primorska, Polje 42, SI-6310 Izola, Slovenia
,
Paola Tedeschi
2   Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
,
Annalisa Maietti
2   Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
,
Mihaela Jurdana
1   Faculty of Health Sciences, University of Primorska, Polje 42, SI-6310 Izola, Slovenia
,
Vincenzo Brandolini
2   Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
,
Zala Jenko Pražnikar
1   Faculty of Health Sciences, University of Primorska, Polje 42, SI-6310 Izola, Slovenia
› Author Affiliations
Further Information

Publication History

received 05 September 2016
revised 14 March 2017

accepted 30 March 2017

Publication Date:
26 April 2017 (online)

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Abstract

Background

Obesity and overweight are major contributors to the burden of chronic disease. Both are defined as abnormal or excessive fat accumulation and by increased production of free radicals leading to oxidative stress. The aim of the present study was to evaluate whether overweight and fat accumulation is associated with serum total antioxidant capacity (TAC) in men and women, irrespective of nutritional habits, nutrient intakes, physical activity, smoking, and other confounders, which may be responsible for modifying the association between serum TAC and overweight/obesity measures.

Methods

This cross-sectional study was conducted on 60 normal weight and 60 overweight adults aged 25–49. All participants underwent standard anthromorphological measurements of body composition, blood pressure and biochemical measurements, aerobic capabilities assessment and dietary intake evaluation. TAC was measured by using the photochemioluminescence method. All data were analysed with SPSS software.

Results

Men had higher values of TAC than women and concentrations of TAC were significantly higher in overweight subjects compared to normal weight subjects. In the present study TAC tended to be increased by various metabolic risk factors, especially overweight/obesity parameters (body mass index, body fat), inflammation and increased serum levels of Cysteine, irrespective of nutritional habits, nutrient intakes, physical activity and smoking.

Conclusions

Overweight and obesity at an early stage may stimulate TAC. Therefore, the elevation of TAC in overweight adults may be a compensatory response to oxidative stress, generated by reactive oxygen species.

Key words

antioxidant capacity - overweight - oxidative stress - metabolic risk factors - asymptomatic population
 

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