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PiD - Psychotherapie im Dialog 2017; 18(03): 29-33
DOI: 10.1055/s-0043-111293
Standpunkte
Georg Thieme Verlag KG Stuttgart · New York

Neurobiologische Aspekte der Dissoziation

Überblick über den Stand der Forschung
Carolin Gebauer
,
Judith Daniels
,
Carsten Spitzer
,
Freya Thiel
Further Information

Publication History

Publication Date:
07 September 2017 (online)

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Dissoziation ist ein Prozess der Desintegration des Bewusstseins, der Identität, des Gedächtnisses und der Wahrnehmung, der vermutlich durch vielfältige neuronale und physiologische Anpassungen charakterisiert ist. Aber was passiert eigentlich genau, wenn sich die Wahrnehmung plötzlich verändert, die Zeit sehr langsam dahinfließt oder Schmerzen kaum noch wahrgenommen werden? Im Folgenden werden die bisherigen Erkenntnisse zu strukturellen und funktionellen Veränderungen zusammengefasst.

 

  • Literatur

  • Barnow S, Limberg A, Stopsack M. et al. Dissociation and emotion regulation in borderline personality disorder. Psychol Med 2012; 42: 783-794
    CrossrefPubMedGoogle Scholar
  • Blanke O, Ortigue S, Landis T. et al. Stimulating illusory own-body perceptions. Nature 2002; 419: 269-270
    CrossrefPubMedGoogle Scholar
  • Bob P, Svetlak M. Dissociative states and neural complexity. Brain Cogn 2011; 75: 188-195
    CrossrefPubMedGoogle Scholar
  • Brandt C, Brechtelsbauer D, Bien CG. et al. “Out-of-body-experience” als mögliches Anfallssymptom bei einem Patienten mit rechtsparietaler Läsion. Nervenarzt 2005; 76: 1259-1262
    CrossrefPubMedGoogle Scholar
  • Bunning S, Blanke O. The out-of body experience: precipitating factors and neural correlates. Prog Brain Res 2005; 150: 331-350
    PubMedGoogle Scholar
  • Cooper NR, Croft RJ, Dominey SJJ. et al. Paradox lost? Exploring the role of alpha oscillations during externally vs. internally directed attention and the implications for idling and inhibition hypotheses. Int J Psychophysiol 2003; 47: 65-74
    CrossrefPubMedGoogle Scholar
  • Daniels JK, Coupland NJ, Hegadoren KM. et al. Neural and behavioral correlates of peritraumatic dissociation in an acutely traumatized sample. J Clin Psychiatry 2012; 73: 420-426
    CrossrefPubMedGoogle Scholar
  • Daniels JK, Gaebler M, Lamke JP. et al. Grey matter alterations in patients with depersonalization disorder: a voxel-based morphometry study. J Psychiatry Neurosci 2015; 40: 19-27
    PubMedGoogle Scholar
  • Daniels JK, Frewen P, Théberge J. et al. Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder. Acta Psychiatr Scand 2016; 133: 232-240
    CrossrefPubMedGoogle Scholar
  • Diveky T, Prasko J. Latalovak. et al. Heart rate variability spectral analysis in patients with panic disorder compared with healthy controls. Neuro Endocrinol Lett 2012; 33: 156-166
    PubMedGoogle Scholar
  • Ebner-Priemer UW, Badeck S, Beckmann C. et al. Affective dysregulation and dissociative experience in female patients with borderline personality disorder: a startle response study. J Psychiatr Res 2005; 39: 85-92
    CrossrefPubMedGoogle Scholar
  • Farina B, Speranza AM, Imperatori C. et al. Change in Heart Rate Variablitity After the Adult. Attachment Interview in Dissociative Patients. J Trauma Diss 2016; 16: 170-180
    PubMedGoogle Scholar
  • Felmingham K, Kemp H, Williams L. et al. Dissociative responses to conscious and non-conscious fear impact underlying brain function in post-traumatic stress disorder. Psychol Med 2008; 38: 1771-1780
    CrossrefPubMedGoogle Scholar
  • Giesbrecht T, Jongen EMM, Smulders FTY. et al. Dissociation, resting EEG, and subjective sleep experiences in undergraduates. J Nerv Ment Dis 2006; 194: 362-368
    CrossrefPubMedGoogle Scholar
  • Giesbrecht T, Merckelbach H, ter Burg L. et al. Acute dissociation predicts rapid habituation of skin conductance responses to aversive auditory probes. J Trauma Stress 2008; 21: 247-250
    CrossrefPubMedGoogle Scholar
  • Griffin MG, Resick PA, Mechanic MB. Objective assessment of peritraumatic dissociation: psychophysiological indicators. Am J Psychiatry 1997; 154: 1081-1088
    CrossrefPubMedGoogle Scholar
  • Hagenaars MA, Oitzl M, Roelofs K. Updating freeze: Aligning animal and human research. Neurosci Biobehav Rev 2014; 47: 165-176
    CrossrefPubMedGoogle Scholar
  • Hopper JW, Frewen PA, van der Kolk BA. et al. Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: Symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery. J Trauma Stress 2007; 20: 713-725
    CrossrefPubMedGoogle Scholar
  • Jay EL, Sierra M, Van den Eynde F. et al. Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation. Brain Stimul 2014; 7: 252-259
    CrossrefPubMedGoogle Scholar
  • Kikuchi H, Fujii T, Abe N. et al. Memory repression: brain mechanisms underlying dissociative amnesia. J Cogn Neurosci 2010; 22: 602-613
    CrossrefPubMedGoogle Scholar
  • Klimova A, Bryant R, Williams L. et al. Dysregulation in cortical reactivity to emotional faces in PTSD patients with high dissociative symptoms. Eur J Psychotraumatol 2013; 4
    PubMedGoogle Scholar
  • Koopman C, Carrion V, Butler LD. et al. Relationships of dissociation and childhood abuse and neglect with heart rate in delinquent adolescents. J Trauma Stress 2004; 17: 47-54
    CrossrefPubMedGoogle Scholar
  • Krüger C, Bartel P, Fletcher L. Dissociative mental states are canonically associated with decreased temporal theta activity on spectral analysis of EEG. J Trauma Dissociation 2013; 14: 473-491
    CrossrefPubMedGoogle Scholar
  • Lanius RA, Williamson PC, Densmore M. et al. Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation. Am J Psychiatry 2001; 158: 1920-1922
    CrossrefPubMedGoogle Scholar
  • Lanius RA, Williamson PC, Bluhm RL. et al. Functional connectivity of dissociative responses in posttraumatic stress disorder: A functional magnetic resonance imaging investigation. Biol Psychiatry 2005; 57: 873-884
    CrossrefPubMedGoogle Scholar
  • Lanius RA, Vermetten E, Loewenstein RJ. et al. Emotion modulation in PTSD: clinical and neurobiological evidence for a dissociative subtype. Am J Psychiatry 2010; 167: 640-647
    CrossrefPubMedGoogle Scholar
  • Lanius RA, Bethany B, Vermetten E. et al. The dissociative subtype of posttraumatic stress disorder: Rationale, clinical and neurobiological evidence, and implications. Depress Anxiety 2012; 29: 701-708
    CrossrefPubMedGoogle Scholar
  • Latalova K, Prasko J, Diveky T. et al. Autonomic nervous system in euthymic patients with bipolar affective disorder. Neuro Endocrinol Lett 2010; 31: 829-836
    PubMedGoogle Scholar
  • Nardo D, Högberg G, Lanius RA. et al. Gray matter volume alterations related to trait dissociation in PTSD and traumatized controls. Acta Psychiatr Scand 2013; 128: 222-233
    CrossrefPubMedGoogle Scholar
  • Nicholson AA, Densmore M, Frewen PA. et al. The dissociative subtype of posttraumatic stress disorder: Unique resting state functional connectivity of basolateral and centromedial amygdala complexes. Neuropsychopharmacology 2015; 40: 2317-2326
    CrossrefPubMedGoogle Scholar
  • Reinders AA, Nijenhuis ER, Quak J. et al. Psychobiological characteristics of dissociative identity disorder: a symptom provocation study. Biol Psychiatry 2006; 60: 730-740
    CrossrefPubMedGoogle Scholar
  • Schmahl CG, Elzinga BM, Bremner JD. Individual differences in psychophysiological reactivity in adults with childhood abuse. Clin Psychol Psychother 2002; 9: 271-276
    CrossrefPubMedGoogle Scholar
  • Shin LM, Wright CI, Cannistraro PA. et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 2005; 62: 273-81
    CrossrefPubMedGoogle Scholar
  • Sierra M, Senior C, Dalton J. et al. Autonomic response in depersonalization disorder. Arch Gen Psychiatry 2002; 59: 833-838
    CrossrefPubMedGoogle Scholar
  • Sierra M, Nestler S, Jay EL. et al. A structural MRI study of cortical thickness in depersonalisation disorder. Psychiatry Res 2014; 224: 1-7
    CrossrefPubMedGoogle Scholar