Intrahepatische Schwangerschaftscholestase

Die Schwangerschaftscholestase (ICP) ist neben Gallensteinen die häufigste Lebererkrankung in der Schwangerschaft, gekennzeichnet durch teilweise heftigen Pruritus und erhöhte Gallensäurenkonzentration im mütterlichen Serum. Die ICP hat eine gute Prognose für die Mutter, kann jedoch den Feten gefährden. Genetische Varianten hepatobiliärer Transporter spielen bei der Entstehung eine wichtige Rolle. Die wirksamste Therapie ist Ursodeoxycholsäure.

• Literatur

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