Incorporation of Fluorinated Pyridine in the Side Chain of 4-Aminoquinolines: Synthesis, Characterization and Antibacterial Activity

Abstract

A series of hybrid of 4-aminoquinoline and fluorinated pyridine derivatives were synthesized and their chemical structure were confirmed by ¹⁹F-NMR, ¹H-NMR, ¹³C-NMR and FT-IR. All compounds were tested against one Gram-positive and one Gram-negative bacteria to assess their in vitro antibacterial activity. Compounds 10a, 10b, 11a and 12b showed moderate antibacterial activity against Gram-positive bacterium, Staphylococcus aureus.

Key words

hydroxy- and amine-functionalized quinoline - pentafluoropyridine - 2,3,5,6-Tetrafluoro-4-phenylsulphonyl pyridine - synthesis - antibacterial activity

• References

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