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Fortschr Neurol Psychiatr 2018; 86(04): 242-255
DOI: 10.1055/s-0043-119799
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© Georg Thieme Verlag KG Stuttgart · New York

Depression im Alter – Diagnostik, Pathophysiologie und therapeutische Strategien

Late life depression – Diagnosis, pathophysiology and therapeutic strategies
Forugh S. Dafsari
,
Frank Jessen
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Publication History

Publication Date:
24 April 2018 (online)

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Zusammenfassung

Depressionen zählen zu den häufigsten psychischen Erkrankungen im höheren Lebensalter. Sie führen zu einer starken Inanspruchnahme von Gesundheitsleistungen und gehen mit erhöhter Morbidität und Mortalität einher. Mit Blick auf den demografischen Wandel stellt die Altersdepression eine große Herausforderung der alternden Gesellschaft dar. Der frühzeitigen Diagnostik und spezifischen Behandlung kommt eine besondere Bedeutung zu.

Abstract

Late-life depression is a frequent and severe mental disorder. It is characterized by alterations in mood as well as cognitive deficits and somatic symptoms. LLD is associated with various adverse outcomes, such as reduced quality of life, negative impact on physical comorbidities, functional impairments, increased suicide and non-suicide mortality. Moreover, LLD serves as a risk factor for developing all-cause dementia, including Alzheimer´s disease. It leads to a frequent use of health care services and remains a serious public health concern. Unfortunately, LLD is often misinterpreted as a physiological aging process and thus remains underdiagnosed and undertreated for years. With a view towards the demographic change LLD is one of the major diagnostic and therapeutic challenges of the aging society. Nevertheless, psychotherapy, pharmacological interventions as well as ECT are effective treatment options. The goal of any treatment for LLD is to ensure full remission, functional recovery and social reintegration.

Schlüsselwörter

Altersdepression - kognitive Defizite - Antidepressiva - Psychotherapie - EKT

Key words

Late-life depression - cognitive deficits - antidepressants - psychotherapy - ECT
 

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