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Int J Sports Med 2017; 38(14): 1105-1110
DOI: 10.1055/s-0043-119883
Clinical Sciences
© Georg Thieme Verlag KG Stuttgart · New York

Cardiac Autonomic Dysfunction in Offspring of Hypertensive Parents During Exercise

Leonardo Barbosa de Almeida
1   Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora, Juiz de Fora, Brazil
,
Tiago Peçanha
2   School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
,
Pedro Augusto de Carvalho Mira
1   Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora, Juiz de Fora, Brazil
,
Livia Victorino de Souza
3   Nephrology Division, Federal University of São Paulo, São Paulo, Brazil
,
Lílian Pinto da Silva
1   Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora, Juiz de Fora, Brazil
,
Daniel Godoy Martinez
1   Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora, Juiz de Fora, Brazil
,
Isabelle Magalhães Guedes Freitas
1   Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora, Juiz de Fora, Brazil
,
Mateus Camaroti Laterza
1   Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora, Juiz de Fora, Brazil
› Author Affiliations
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Publication History



accepted 06 September 2017

Publication Date:
19 October 2017 (online)

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Abstract

Offspring of hypertensive parents present autonomic dysfunction at rest and during physiological maneuvers. However, the cardiac autonomic modulation during exercise remains unknown. This study tested whether the cardiac autonomic modulation would be reduced in offspring of hypertensive parents during exercise. Fourteen offspring of hypertensive and 14 offspring of normotensive individuals were evaluated. The groups were matched by age (24.5±1.0 vs. 26.6±1.5 years; p=0.25) and BMI (22.8±0.6 vs. 24.2±1.0 kg/m2; p=0.30). Blood pressure and heart rate were assessed simultaneously during 3 min at baseline followed by 3-min isometric handgrip at 30% of maximal voluntary contraction. Cardiac autonomic modulation was evaluated using heart rate variability. Primary variables were subjected to two-way ANOVA (group vs. time). P value<0.05 was considered statistically significant. Blood pressure and heart rate were similar between groups during exercise protocol. In contrast, offspring of hypertensive subjects showed a reduction of SDNN (Basal=34.8±3.5 vs. 45.2±3.7 ms; Exercise=30.8±3.3 vs. 41.5±3.9 ms; p group=0.01), RMSSD (Basal=37.1±3.7 vs. 52.0±6.0 ms; Exercise=28.6±3.4 vs. 41.9±5.3 ms; p group=0.02) and pNN50 (Basal=15.7±4.0 vs. 29.5±5.5%; Exercise=7.7±2.4 vs. 18.0±4.3%; p group=0.03) during the exercise protocol in comparison with offspring of normotensive parents. We concluded that normotensive offspring of hypertensive parents exhibit impaired cardiac autonomic modulation during exercise.

Key words

hypertension - autonomic nervous system - heredity - exercise
 

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